Phenotype >
| Project data set: Berndt2 (2010) |
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| | Project |
Unrestrained plethysmograph and anesthetized forced oscillation methods of measuring lung function in 29 inbred strains of mice
Mice were assessed for respiratory parameters at baseline and then
again after methacholine (MCh)
challenge using two different techniques in two cohorts:
1) unrestrained
plethysmograph technique (BUXCO), given MCh doses of 5, 10, and 20 mg/mL; 2)
anesthetized forced oscillation technique (FlexiVent), given MCh doses of 1, 3, 10, and 30 mg/mL . The
"MCh response index" is the average slope of the MCh challenge series (see protocol for details).
Study design:
baseline and intervention in various doses;
2 cohorts.
29 strains tested
Test age:
9-12wks
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| Investigators |
Berndt A, Leme AS, Paigen B, Shapiro SD, Svenson KL
[Details, papers]
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| Protocol |
View phenotyping protocol and methods
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Berndt2
measurements
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Number of mice tested per strain, for each measurement
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| Changelog |
There has been
one update or correction
to the data set since MPD release
in
Mar 2011
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| Reference |
Berndt A, Leme AS, Williams LK, Von Smith R, Savage HS, Stearns TM, Tsaih SW, Shapiro SD, Peters LL, Paigen B, Svenson KL. Comparison of unrestrained plethysmography and forced oscillation for identifying genetic variability of airway responsiveness in inbred mice.
Physiol Genomics. 2011 Jan 7;43(1):1-1Epub 2010 Sep 7.
PubMed 20823217
MGI
FullText
Related papers
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| Mice |
Strain and animal info
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| Note |
Caution: Very low sample sizes (N < 3) are present.
[View table]
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| Note |
Some measurements are a mixture of + and – values. [View list]
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Berndt2
downloads
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See also the MPD download center for more general data download options.
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