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Project data set: Bennett3   (2007)

Project Acute functional tolerance to ethanol in 74 ILSXISS recombinant inbred strains of mice

Alcohol sensitivity and acute alcohol tolerance were studied in a single cohort of mice using a test of ataxia: loss and regain of balance on a stationary wooden dowel upon exposure to two doses of EtOH within the same testing session.

Study design: all mice subjected to an intervention; 1 cohort.
74 strains tested     female male     Test age: 8-14wks

Investigators Bennett B, Johnson TE   [Details, papers]

Protocol View phenotyping protocol and methods

Bennett3
measurements



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blood — xenobiotics — alcohol concentration         spectrophotometry  
Bennett3
blood ethanol concentration (BEC) [mg/mL]   ethanol  
      • first loss of balance (ataxia)  • first regain of balance  • second regain of balance    • comparison  
72 strains   age 8-14wks
  ILSXISS
Bennett3
acute functional tolerance to two-stage injections of EtOH [mg/mL]   ethanol  
      • as a function of first regain of balance  • as a function of first loss of balance    • comparison  
72 strains   age 8-14wks
  ILSXISS



Number of mice tested per strain, for each measurement

  
Changelog There have been no updates or corrections to the data set since MPD release in Jul 2011  
Reference
Bennett B, Downing C, Carosone-Link P, Ponicsan H, Ruf C, Johnson TE. Quantitative trait locus mapping for acute functional tolerance to ethanol in the L x S recombinant inbred panel. Alcohol Clin Exp Res. 2007 Feb;31(2):200-8.     PubMed 17250610     MGI

Related papers
Mice
Strain and animal info
Note
Strain names for mice tested prior to importation to The Jackson Laboratory have been updated using current strain nomenclature and assigned JAX vendor codes (if available) in order to facilitate comparisons across projects.
Note
Caution: Very low sample sizes (N < 3) are present. [View table]
Note
Some measurements are a mixture of + and – values. [View list]

Bennett3
downloads


Individual animal data
Table format (.csv)
Individual animal data in table format, with one row per animal and one column per measurement.
Individual animal data
List format (.csv)
Individual animal data organized as one row per animal / measurement reading.
Strain means (.csv) Strain means with SD, N, other summary statistics. One row per strain / sex / measurement.
No supplemental data for this project. 

 See also the MPD download center for more general data download options.





 




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