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Data set: Xing1   (2008)

  Aging study: Electrocardiogram for 29 inbred strains of mice
 
 

Study design: aging study (longitudinal)   1 cohort.
29 strains tested (inbred)     female male     Test age: 6, 12, 20 mo
Sample sizes are 7.4 on average. ... Caution, some N ≤ 2 are present  [details]

  Investigators: Xing S, Korstanje R, Paigen B     [More info... papers, citing, funding]
Jackson Laboratory Nathan Shock Center

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Xing1
phenotype
measurements



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cardiovascular — ECG parameters — conscious         ECG  
Xing1
interval RR [ms]        
• 6mo  • 12mo  • 20mo      age comparison  
29 strains   aging study
  Inbred
Xing1
interval PR [ms]        
• 6mo  • 12mo  • 20mo      age comparison  
29 strains   aging study
  Inbred
Xing1
interval QRS [ms]        
• 6mo  • 12mo  • 20mo      age comparison  
29 strains   aging study
  Inbred
Xing1
interval QT [ms]        
• 6mo  • 12mo  • 20mo      age comparison  
29 strains   aging study
  Inbred
Xing1
interval ST [ms]        
• 6mo  • 12mo  • 20mo      age comparison  
29 strains   aging study
  Inbred
 
cardiovascular — heart rate — conscious         ECG  
Xing1
heart rate [n/min]        
• 6mo  • 12mo  • 20mo      age comparison  
29 strains   aging study
  Inbred




Note that testing was done at age 20 months, not at 18 and 24 months as is usually the case with Jackson Aging Center projects.

Due to the difficulties in determining the exact beginning and ending of the T-wave in conscious mice, automatic software generated values for QT and ST intervals should be used with caution (see Figure 4 in the Xing1 protocol).



UCLA EMMA GWAS results are available for this project.

One update or correction was posted since initial release in May 2009

 
Xing S, Tsaih SW, Yuan R, Svenson KL, Jorgenson LM, So M, Paigen BJ, Korstanje R. Genetic influence on electrocardiogram time intervals and heart rate in aging mice. Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1907-13. Epub 2009 Apr 24.     PubMed 19395551     MGI     FullText

See also a related paper




 




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