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Data set: Petkova1   (2007)

  Aging study: Peripheral blood leukocytes (PBL profiles) in 32 inbred strains of mice
  An investigation of aging effects on immune system. Animals were evaluated using flow cytometry.
 

Study design: aging study (longitudinal)   1 cohort.
32 strains tested (inbred)     female male     Test age: 6, 12, 18, 24 mo
Sample sizes are 7.4 on average. ... Caution, some N ≤ 2 are present  [details]

  Investigators: Petkova S, Roopenian D     [More info... papers, citing, funding]
Jackson Laboratory Nathan Shock Center

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Petkova1
phenotype
measurements



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blood — hematology — cell counts         complete blood count  
Petkova1
white blood cell count (WBC) [n/µL]        
• 6mo  • 12mo  • 18mo  • 24mo      age comparison  
32 strains   aging study
  Inbred
Petkova1
eosinophil differential [%]        
• 6mo  • 12mo  • 18mo  • 24mo      age comparison  
32 strains   aging study
  Inbred
Petkova1
lymphocyte differential [%]        
• 6mo  • 12mo  • 18mo  • 24mo      age comparison  
32 strains   aging study
  Inbred
Petkova1
monocyte differential [%]        
• 6mo  • 12mo  • 18mo  • 24mo      age comparison  
32 strains   aging study
  Inbred
Petkova1
neutrophil differential [%]        
• 6mo  • 12mo  • 18mo  • 24mo      age comparison  
32 strains   aging study
  Inbred
 
immune system — cell counts — peripheral blood — B cells         immune cell quantification  
Petkova1
B cells [%]        
• 6mo  • 12mo  • 18mo  • 24mo      age comparison  
32 strains   aging study
  Inbred
 
immune system — cell counts — peripheral blood — NK cells         immune cell quantification  
Petkova1
NK cells [%]        
• 6mo  • 12mo  • 18mo  • 24mo      age comparison  
32 strains   aging study
  Inbred
 
immune system — cell counts — peripheral blood — T cells         immune cell quantification  
Petkova1
CD4 T cells [%]        
• 6mo  • 12mo  • 18mo  • 24mo      age comparison  
32 strains   aging study
  Inbred
Petkova1
CD4 T cells - naive cells [%]        
• 6mo  • 12mo  • 18mo  • 24mo      age comparison  
32 strains   aging study
  Inbred
Petkova1
CD4 T cells - central memory cells [%]        
• 6mo  • 12mo  • 18mo  • 24mo      age comparison  
32 strains   aging study
  Inbred
Petkova1
CD4 T cells - effector memory cells [%]        
• 6mo  • 12mo  • 18mo  • 24mo      age comparison  
32 strains   aging study
  Inbred
Petkova1
CD4 T cells - effector cells [%]        
• 6mo  • 12mo  • 18mo  • 24mo      age comparison  
32 strains   aging study
  Inbred
Petkova1
CD8 T cells [%]        
• 6mo  • 12mo  • 18mo  • 24mo      age comparison  
32 strains   aging study
  Inbred
Petkova1
CD8 T cells - naive cells [%]        
• 6mo  • 12mo  • 18mo  • 24mo      age comparison  
32 strains   aging study
  Inbred
Petkova1
CD8 T cells - central memory cells [%]        
• 6mo  • 12mo  • 18mo  • 24mo      age comparison  
32 strains   aging study
  Inbred
Petkova1
CD8 T cells - effector memory cells [%]        
• 6mo  • 12mo  • 18mo  • 24mo      age comparison  
32 strains   aging study
  Inbred
Petkova1
CD8 T cells - effector cells [%]        
• 6mo  • 12mo  • 18mo  • 24mo      age comparison  
32 strains   aging study
  Inbred




UCLA EMMA GWAS results are available for this project.

One update or correction was posted since initial release in Jun 2009
 
Petkova SB, Yuan R, Tsaih SW, Schott W, Roopenian DC, Paigen B. Genetic influence on immune phenotype revealed strain-specific variations in peripheral blood lineages. Physiol Genomics. 2008 Aug 15;34(3):304-14. Epub 2008 Jun 10.     PubMed 18544662     MGI     FullText

See also a related paper




 




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