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Phenotype >
Intervention studies

MPD includes a number of studies where a foreign substance or pathogen was administered, or an environmental perturbation was introduced and compared against a control cohort or baseline readings. Most of the links below lead to phenotype data pages ... on those pages you can click on symbols to view methods and protocols. Specific interventions are organized below into sections for: diet; drugs; exercise; pathogens and parasites; and toxicity, challenges and mutagens.
Include  
 
diet-related
  high-fat diet    
  high-fat diet and ethanol   liver study  
  restricted diet   reduced food amount  
  salt (NaCl)   table salt NaCl  
  sucrose   table sugar  
 
drugs and alcohol
  acetaminophen   pain reliever e.g. Tylenol  
  atenolol   treatment for cardiovascular disorders  
  cocaine   psychostimulant  
  DB289   antiparasitic  
  diazepam   anxiety reliever e.g. Valium  
  ethanol   alcohol EtOH  
  fluoxetine   antidepressant e.g. Prozac  
  haloperidol   antipsychotic  
  high-fat diet and ethanol   liver study  
  imipramine   antidepressant  
  isoniazid   treatment for tuberculosis  
  isoproterenol   treatment for cardiovascular disorders  
  lamotrigine   anticonvulsant  
  lithium   mood stabilizer  
  methacholine   bronchoconstrictor, respiratory tests  
  methamphetamine   psychostimulant  
  nicotine   component of tobacco smoke  
  pilocarpine   convulsant  
  quinelorane   dopamine agonist  
  R-6-Br-APB   dopamine agonist  
 
exercise
  exercise   option/availability of running wheel  
 
pathogens / parasites
  Bacillus anthracis lethal toxin   anthrax  
  Candida albicans   fungal infection  
  influenza A (H1N1) virus   viral infection  
  influenza A (H5N1) virus   viral infection  
  P.gingivalis and F.nucleatum   periodontal pathogenic bacteria: Porphyromonas gingivalis and Fusobacterium nucleatum  
  Plasmodium berghei   malaria  
  Plasmodium chabaudi   malaria  
  Staphylococcus aureus   bacterial infection  
 
toxicity / challenges / mutagens
  acetaminophen   pain reliever e.g. Tylenol  
  cadmium   toxicity  
  ENU   ethylnitrosourea, mutagen  
  methacholine   bronchoconstrictor, respiratory tests  
  ovalbumin   allergen, repiratory challenge  
  radiation   ionizing radiation  
  sleep deprivation   sleep deprivation  
  trichloroethylene   (TCE) industrial contaminant  



Some terms may appear more than once in the above list.

The following are not included above:
    • glucose and insulin tolerance tests
    • ingestive preference tests
    • nociception tests where substance / perturbation is a pain inducer



 




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