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Intervention studies

Studies where a foreign substance or pathogen was administered or an environmental perturbation was introduced and compared against a control cohort or baseline readings. See bottom of page for exceptions.

The list below includes these sections:     • diets     • drugs and alcohol     • exercise     • pathogens / parasites     • toxicity / challenges / mutagens
  high-fat diet   diet high in fat pheno, QTL, expr
  high-fat diet and ethanol   effect on liver of fat and ethanol together pheno
  high-fat high-sucrose diet   effect on liver of fat and sucrose together pheno
  macronutrient diet option   choice of fat or carbohydrate QTL
  restricted diet   reduced food amount pheno
  sodium chloride   table salt NaCl pheno, QTL
  sucrose   table sugar pheno
  western diet   diet with typical Western characteristics QTL
drugs and alcohol
  acetaminophen   pain reliever e.g. Tylenol pheno
  atenolol   treatment for cardiovascular disorders pheno
  BEZ235   anti-cancer drug, anti-neoplastic pheno
  captopril   antihypertensive agent, hyperglycemia study misc
  cocaine   psychostimulant pheno, QTL
  cyclophosphamide   alkylating agent, lupus erythematosus (SLE)) study misc
  DB289   antiparasitic pheno
  diazepam   anxiety reliever e.g. Valium pheno
  docetaxel   anti-mitotic chemotherapy medication, cancer study misc
  doxorubicin   anti-cancer drug, anti-neoplastic pheno
  ethanol   alcohol EtOH pheno, QTL
  fluoxetine   antidepressant e.g. Prozac pheno
  glatiramer acetate   immunosuppressive agent, inflammatory bowel disease study misc
  haloperidol   antipsychotic pheno
  idarubicin   anti-cancer drug, anti-neoplastic pheno
  imipramine   antidepressant pheno
  isoniazid   treatment for tuberculosis pheno
  isoproterenol   treatment for cardiovascular disorders pheno
  lamotrigine   anticonvulsant pheno
  L-DOPA   dopamine agent, Parkinson's Disease study misc
  lithium   mood stabilizer pheno
  metformin   anti-diabetic, anti aging misc, ITP
  methamphetamine   psychostimulant pheno
  nicotine   component of tobacco smoke pheno
  olanzapine   treatment for schizophrenia and bipolar pheno
  paclitaxel   anti-mitotic chemotherapy medication, cancer study misc
  pilocarpine   convulsant pheno
  quinelorane   dopamine agonist pheno
  R-6-Br-APB   dopamine agonist pheno
  rosiglitazone   hypoglycemic agent, diabetes and obesity studies misc
  salbutamol   bronchodilator agent, asthma studies misc
  selumetinib   anti-cancer drug, anti-neoplastic pheno
living environment perturbations
  exercise   option/availability of running wheel pheno
pathogens / parasites
  Bacillus anthracis lethal toxin   anthrax pheno
  Candida albicans   fungal infection pheno
  F.nucleatum   (Fusobacterium nucleatum), periodontal pathogenic bacteria pheno
  influenza A (H1N1) virus   viral infection pheno
  influenza A (H3N2) virus   viral infection pheno
  influenza A (H5N1) virus   viral infection pheno
  P.gingivalis   (Porphyromonas gingivalis), periodontal pathogenic bacteria pheno
  Plasmodium berghei   malaria pheno
  Plasmodium chabaudi   malaria pheno
  Staphylococcus aureus   bacterial infection pheno
  Streptococcus zooepidemicus   respiratory challenge study misc
toxicity / challenges / mutagens
  benzene   elementary petrochemical pheno
  cadmium   study of cadmium toxicity pheno
  dextran sulfate   colitis inducer QTL
  ENU   ethylnitrosourea, mutagen pheno
  lipopolysaccharide   (LPS) endotoxin, respiratory challenge expr, misc
  methacholine   bronchoconstrictor, respiratory tests pheno, QTL
  ovalbumin   allergen, repiratory challenge pheno
  OxPAPC   TLR signalling inhibitor expr
  ozone   air pollutant, respiratory challenge misc
  radiation   ionizing radiation pheno
  tetrachloroethylene   pheno
  trichloroethylene   (TCE) industrial contaminant pheno, expr
  tumor cell xenograft   patient-derived tumor xenografts QTL
  ultraviolet light   ultraviolet radiation QTL

    The following are not considered "interventions" for our purposes:
    • Substances offered in ingestive preference tests
    Glucose tolerance tests and similar
    • Where a perturbation is done as necessary preparation for a phenotyping procedure but it's not the primary focus of the study question or study design, such as fasting period before blood studies, pain inducers in nociception tests, or preliminary surgery to induce a certain condition.


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