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Phenotype >
Intervention studies

MPD includes a number of studies where a foreign substance or pathogen was administered, or an environmental perturbation was introduced and compared against a control cohort or baseline readings. Most of the links below lead to phenotype data pages; on those pages you can click on symbols to view methods and protocols. There are also linkouts to Wikipedia (etc) for more information on many of the interventions.

The list below includes these sections:     • diets     • drugs and alcohol     • exercise     • pathogens / parasites     • toxicity / challenges / mutagens
  high-fat diet   diet high in fat   [1]
  high-fat diet and ethanol   effect of fat and ethanol on liver    
  high-fat diet and olanzapine   treatment for schizophrenia and bipolar    
  macronutrient diet option   macronutrient diet option   [2]
  restricted diet   reduced food amount    
  salt (NaCl)   table salt NaCl   [1]
  sucrose   table sugar    
  western diet   diet with typical Western characteristics   [2]
drugs and alcohol
  acetaminophen   pain reliever e.g. Tylenol    
  atenolol   treatment for cardiovascular disorders    
  captopril   antihypertensive agent, hyperglycemia study   [2]
  cocaine   psychostimulant   [1]
  cyclophosphamide   alkylating agent, lupus erythematosus study   [2]
  DB289   antiparasitic    
  diazepam   anxiety reliever e.g. Valium    
  docetaxel   anti-mitotic chemotherapy medication, cancer study   [2]
  ethanol   alcohol EtOH   [1]
  ethanol and high-fat diet   effect of fat and ethanol on liver    
  fluoxetine   antidepressant e.g. Prozac    
  glatiramer acetate   immunosuppressive agent, inflammatory bowel disease study   [2]
  haloperidol   antipsychotic    
  imipramine   antidepressant    
  isoniazid   treatment for tuberculosis    
  isoproterenol   treatment for cardiovascular disorders    
  lamotrigine   anticonvulsant    
  L-DOPA   dopamine agent, Parkinson's Disease study   [2]
  lithium   mood stabilizer    
  metformin   hypoglycemic agent, diabetes study   [2]
  methamphetamine   psychostimulant    
  nicotine   component of tobacco smoke    
  olanzapine and high-fat diet   treatment for schizophrenia and bipolar    
  paclitaxel   anti-mitotic chemotherapy medication, cancer study   [2]
  pilocarpine   convulsant    
  quinelorane   dopamine agonist    
  R-6-Br-APB   dopamine agonist    
  rosiglitazone   hypoglycemic agent, diabetes and obesity studies   [2]
  salbutamol   bronchodilator agent, asthma studies   [2]
  exercise   option/availability of running wheel    
pathogens / parasites
  Bacillus anthracis lethal toxin   anthrax    
  Candida albicans   fungal infection    
  influenza A (H1N1) virus   viral infection    
  influenza A (H5N1) virus   viral infection    
  P.gingivalis and F.nucleatum   periodontal pathogenic bacteria: Porphyromonas gingivalis and Fusobacterium nucleatum    
  Plasmodium berghei   malaria    
  Plasmodium chabaudi   malaria    
  Staphylococcus aureus   bacterial infection    
  Streptococcus zooepidemicus   respiratory challenge study   [2]
toxicity / challenges / mutagens
  cadmium   toxicity    
  ENU   ethylnitrosourea, mutagen    
  lipopolysaccharide (LPS)   endotoxin, respiratory challenge   [2]
  methacholine   bronchoconstrictor, respiratory tests   [1]
  ovalbumin   allergen, repiratory challenge    
  OxPAPC   TLR signalling inhibitor   [2]
  ozone   air pollutant, respiratory challenge   [2]
  radiation   ionizing radiation    
  trichloroethylene   (TCE) industrial contaminant   [1]
  UV radiation   ultraviolet radiation   [2]

Data are available as phenotype strain survey measurements unless otherwise noted:
[1] Data are also available in archive study or gene expression study.
[2] Data are available in an archive or gene expression study(s) only.

Some terms may appear more than once in the above list. The following are not included:
      • glucose and insulin tolerance tests
      • ingestive preference tests
      • nociception tests where substance / perturbation is a pain inducer


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