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MPD - Phenotype data: monitoring system
behavior methodologies
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monitoring system
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behavior — exploratory
monitoring system
Spijker2
home cage latencies [s]
• exploring novel object
• exploring novel object with food
• eating from familiar object
• eating from novel object
• comparison
12
strains
age
6wks
inbred and BXD
Spijker2
home cage durations [s]
• exploring novel object
• exploring novel object with food
• comparison
12
strains
age
6wks
inbred and BXD
Spijker2
novel cage latencies [s]
• exploring familiar object with food
• eating from familiar object
• comparison
12
strains
age
6wks
inbred and BXD
behavior — fear conditioning — cued
monitoring system
Gould2
acute group, cued fear: pre-cue [%]
control and
nicotine
• control
nicotine dose (mg):
• 0.045
• 0.09
• 0.18
• comparison
8
strains
age
8-12wks
Inbred
Gould2
acute group, cued fear: cue [%]
control and
nicotine
• control
nicotine dose (mg):
• 0.045
• 0.09
• 0.18
• comparison
8
strains
age
8-12wks
Inbred
Gould2
compare pre-cue vs. cue
control
nicotine dose (mg):
0.045
0.09
0.18
8
strains
age
8-12wks
Inbred
Gould2
chronic group, cued fear: pre-cue [%]
control and
nicotine
12mg
• control
• nicotine
• comparison
8
strains
age
8-12wks
Inbred
Gould2
chronic group, cued fear: cue [%]
control and
nicotine
12mg
• control
• nicotine
• comparison
8
strains
age
8-12wks
Inbred
Gould2
compare pre-cue vs. cue
control
nicotine
8
strains
age
8-12wks
Inbred
Gould3
withdrawal group: cued fear: pre-cue [%]
control and
nicotine
• control
nicotine dose (mg)
• 3
• 6.3
• 12
• comparison
8
strains
age
8-12wks
Inbred
Gould3
withdrawal group: cued fear: cue [%]
control and
nicotine
• control
nicotine dose (mg)
• 3
• 6.3
• 12
• comparison
8
strains
age
8-12wks
Inbred
HMDPpheno4
thigmotaxis [%]
all HMDP:
• pre-cue
• cue
• comparison
inbreds:
• pre-cue
• cue
• comparison
AXB BXA:
• pre-cue
• cue
• comparison
BXD:
• pre-cue
• cue
• comparison
BXH:
• pre-cue
• cue
• comparison
94
strains
age
10wks
HMDP
HMDPpheno4
velocity
all HMDP:
• pre-cue
• cue
• comparison
inbreds:
• pre-cue
• cue
• comparison
AXB BXA:
• pre-cue
• cue
• comparison
BXD:
• pre-cue
• cue
• comparison
BXH:
• pre-cue
• cue
• comparison
94
strains
age
10wks
HMDP
HMDPpheno4
immobility [%]
all HMDP:
• pre-cue
• cue
• comparison
inbreds:
• pre-cue
• cue
• comparison
AXB BXA:
• pre-cue
• cue
• comparison
BXD:
• pre-cue
• cue
• comparison
BXH:
• pre-cue
• cue
• comparison
94
strains
age
10wks
HMDP
behavior — locomotor activity
monitoring system
Crabbe2
horizontal distance traveled (immediately to 15 min post-injection) [cm]
baseline and
diazepam
• baseline
doses mg/kg:
• 2
• 4
• 8
• 16
• comparison
15
strains
age
6-7wks
Inbred
Crabbe2
vertical (rearing) activity (immediately to 15 min post-injection) [n]
baseline and
diazepam
• baseline
doses mg/kg:
• 2
• 4
• 8
• 16
• comparison
15
strains
age
6-7wks
Inbred
Evsikova1
ambulatory activity (beam break triplets during 24h) [n]
• daily
• light
• dark
• comparison
12
strains
age
6mo
Inbred
Evsikova1
rearing activity (beam break triplets during 24h) [n]
• daily
• light
• dark
• comparison
12
strains
age
6mo
Inbred
Kas1
home cage activity [cm]
• novelty condition
• day 3
• comparison
6
strains
age
5-7mo
Inbred
Mitchell1
ambulatory activity [cm]
• day2 activity
• habituation
15
strains
age
5-7wks
Inbred
Mogil2
amount of activity (number of beam breaks in 4h period) [n]
• light
• dark
• dark w/saline injection
• time period comparison
12
strains
age
6-10wks
Inbred
Richfield1
horizontal beam breaks
counts (45min session):
• daily avg
• day1
• day2
• day3
• day1-3 comparison
• beam breaks per min
• short-term habituation
• long-term habituation
15
strains
age
7-9wks
Inbred
Richfield1
ambulatory activity
counts (45min session):
• daily avg
• day1
• day2
• day3
• day1-3 comparison
• ambulatory activity per min
• short-term habituation
• long-term habituation
15
strains
age
7-9wks
Inbred
Richfield1
vertical beam breaks (rearing)
counts (45min session):
• daily avg
• day1
• day2
• day3
• day1-3 comparison
• beam breaks per min
• short-term habituation
• long-term habituation
15
strains
age
7-9wks
Inbred
Richfield1
compare habituation for the above tests
short-term habituation
long-term habituation
15
strains
age
7-9wks
Inbred
Seburn1
total activity (beam breaks per min)
• daily
• light
• dark
• comparison
16
strains
age
7-9wks
Inbred
Seburn1
ambulatory activity (beam breaks per min)
• daily
• light
• dark
• comparison
16
strains
age
7-9wks
Inbred
Seburn1
rearing activity (beam breaks per min)
• daily
• light
• dark
• comparison
16
strains
age
7-9wks
Inbred
Thomsen1
total activity, test 1 [n]
baseline and
cocaine
• baseline
dose mg/kg i.p.:
• 3
• 10
• 18
• 32
• 56
• comparison
15
strains
age
8-10wks
Inbred
Thomsen1
total activity, test 2 [n]
baseline and
cocaine
• baseline
dose mg/kg i.p.:
• 3
• 10
• 32
• comparison
15
strains
age
8-10wks
Inbred
Thomsen1
comparison of test1 vs. test2
cocaine
baseline
dose mg/kg i.p.:
3
10
32
15
strains
age
8-10wks
Inbred
Thomsen2
total activity, dose response to D1 agonist [n]
baseline and
R-6-Br-APB
• baseline
dose mg/kg i.p.
• 0.03
• 0.32
• 3.2
• 5.6
• comparison
15
strains
age
8-10wks
Inbred
Thomsen2
total activity, dose response to D2 agonist [n]
baseline and
quinelorane
• baseline
dose mg/kg i.p.
• 0.03
• 0.32
• 3.2
• 5.6
• comparison
15
strains
age
8-10wks
Inbred
Thomsen2
comparison of D1 agonist vs. D2 agonist
baseline
dose mg/kg i.p.
0.03
0.32
3.2
5.6
15
strains
age
8-10wks
Inbred
metabolism — energy
monitoring system
Seburn1
body heat production [kcal/h]
• daily
• light
• dark
• comparison
16
strains
age
7-9wks
Inbred
Seburn1
caloric intake [kcal/d]
• daily
• daily adj for body weight
16
strains
age
7-9wks
Inbred
metabolism — food intake
monitoring system
Evsikova1
food intake [g]
• daily
• light
• dark
• comparison
12
strains
age
6mo
Inbred
Evsikova1
food intake adjusted for body weight [g/kg]
• test start
• test end
• comparison
12
strains
age
6mo
Inbred
Seburn1
food intake [g]
• daily
• daily adj for body weight
16
strains
age
7-9wks
Inbred
metabolism — respiratory
monitoring system
Seburn1
oxygen volume [mL/kg/h]
• daily
• light
• dark
• comparison
16
strains
age
7-9wks
Inbred
Seburn1
carbon dioxide volume [mL/kg/h]
• daily
• light
• dark
• comparison
16
strains
age
7-9wks
Inbred
Seburn1
respiratory exchange ratio
• daily
• light
• dark
• comparison
16
strains
age
7-9wks
Inbred
metabolism — water intake
monitoring system
Evsikova1
water intake [mL]
• daily
• light
• dark
• comparison
12
strains
age
6mo
Inbred
Seburn1
water intake [mL]
• daily
• daily adj for body weight
• 3 day total
16
strains
age
7-9wks
Inbred
reproduction — fertility — female
monitoring system
Donahue18
gestation duration
[h]
15
strains
age
6-8wks
Inbred
Donahue19
gestation duration
[h]
22
strains
age
6-8wks
B6.A consomic
sleep patterns
monitoring system
Chesler2
baseline [%]
• total
• dark period
• comparison
62
strains
age
various
CC diallel
Chesler2
after sleep deprivation
• total
• dark period
• peak activity
• comparison
62
strains
age
various
CC diallel
Chesler3
baseline [%]
• total
• dark period
• comparison
age
various
CC pre
Chesler3
after sleep deprivation
• total
• dark period
• peak activity
• comparison
age
various
CC pre
170 measurements listed.
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