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MPD - Phenotype data: metabolic panel
methodologies
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metabolic panel
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•Inbred only
•Other only
•By strain panel
basic list
show overall averages
show C57BL/6J averages
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verbose descriptions
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blood — clinical chemistry — bilirubin
metabolic panel
CGDpheno1
total bilirubin (plasma TBIL)
[µmol/L]
72
strains
age
12wks
Inbred
Eumorphia1
total bilirubin (plasma TBIL)
[µmol/L]
4
strains
age
12wks
Inbred
RIKEN-EAD1
total bilirubin (plasma TBIL)
[mg/dL]
35
strains
age
8wks
Inbred
Yuan3
bilirubin (serum TBIL) [µmol/L]
• 6mo
• 12mo
• 18mo
• age comparison
31
strains
ages shown
Inbred
Lake1
total bilirubin (plasma TBIL)
[mg/dL]
23
strains
age
8wks
B6.A consomic
Donahue9
total bilirubin (plasma TBIL)
[mg/dL]
25
strains
age
11wks
B6.PWD consomic
Svenson3
total bilirubin (plasma TBIL)
[mg/dL]
21
strains
age
8wks
B6.PWD consomic
RIKEN-EAD2
total bilirubin (plasma TBIL)
[mg/dL]
26
strains
age
8wks
wild-derived RBRC
blood — clinical chemistry — electrolytes — anion gap
metabolic panel
Chesler2
anion gap concentration (mEq/L)
[mmol/L]
62
strains
age
various
CC diallel
Chesler3
anion gap concentration (mEq/L)
[mmol/L]
age
various
CC pre
blood — clinical chemistry — electrolytes — calcium
metabolic panel
Eumorphia1
calcium (plasma Ca)
[mg/dL]
6
strains
age
12wks
Inbred
Jaxpheno3
calcium [mg/dL]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
RIKEN-EAD1
calcium (plasma Ca)
[mg/dL]
35
strains
age
8wks
Inbred
Shockley1
calcium (Ca) [mg/dL] control and
high-fat diet
4wks
• control diet
• high-fat diet
• difference
• comparison
10
strains
age
10-13wks
Inbred
Tordoff3
blood ionized calcium [mg/dL]
• Ca
• Ca adj to pH 7.4
• comparison
40
strains
age
13-15wks
Inbred
Tordoff3
plasma total calcium
[mg/dL]
40
strains
age
13-15wks
Inbred
Yuan3
calcium (serum Ca) [mg/dL]
• 6mo
• 12mo
• 18mo
• age comparison
31
strains
ages shown
Inbred
Donahue9
calcium (serum Ca)
[mg/dL]
25
strains
age
11wks
B6.PWD consomic
Chesler2
calcium (blood ionized Ca)
[mmol/L]
62
strains
age
various
CC diallel
Chesler3
calcium (blood ionized Ca)
[mmol/L]
age
various
CC pre
RIKEN-EAD2
calcium (plasma Ca)
[mg/dL]
26
strains
age
8wks
wild-derived RBRC
blood — clinical chemistry — electrolytes — chloride
metabolic panel
CGDpheno1
chloride (plasma Cl)
[mmol/L]
72
strains
age
10wks
Inbred
Eumorphia1
chloride (plasma Cl)
[mmol/L]
6
strains
age
12wks
Inbred
Yuan3
chloride (serum Cl) [mmol/L]
• 6mo
• 12mo
• 18mo
• age comparison
31
strains
ages shown
Inbred
Donahue9
chloride (serum Cl)
[mmol/L]
25
strains
age
11wks
B6.PWD consomic
Chesler2
chloride (blood Cl)
[mmol/L]
62
strains
age
various
CC diallel
Chesler3
chloride (blood Cl)
[mmol/L]
age
various
CC pre
blood — clinical chemistry — electrolytes — iron
metabolic panel
Eumorphia1
iron (plasma Fe)
[µmol/L]
4
strains
age
12wks
Inbred
RIKEN-EAD1
iron (plasma Fe)
[µg/dL]
35
strains
age
8wks
Inbred
Yuan3
iron (serum Fe) [mmol/L]
• 6mo
• 12mo
• 18mo
• age comparison
31
strains
ages shown
Inbred
RIKEN-EAD2
iron (plasma Fe)
[µg/dL]
26
strains
age
8wks
wild-derived RBRC
blood — clinical chemistry — electrolytes — magnesium
metabolic panel
Yuan3
magnesium (serum Mg) [mmol/L]
• 6mo
• 12mo
• 18mo
• age comparison
31
strains
ages shown
Inbred
Donahue9
magnesium (serum Mg)
[mg/dL]
25
strains
age
11wks
B6.PWD consomic
blood — clinical chemistry — electrolytes — phosphorus
metabolic panel
Eumorphia1
phosphorus (plasma P)
[mg/dL]
6
strains
age
12wks
Inbred
Jaxpheno3
phosphorus [mg/dL]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
RIKEN-EAD1
inorganic phosphorus (plasma PO
4
)
[mg/dL]
35
strains
age
8wks
Inbred
Yuan3
phosphorus (serum P) [mg/dL]
• 6mo
• 12mo
• 18mo
• age comparison
31
strains
ages shown
Inbred
Donahue9
phosphorus (serum P)
[mg/dL]
25
strains
age
11wks
B6.PWD consomic
RIKEN-EAD2
inorganic phosphorus (plasma PO
4
)
[mg/dL]
26
strains
age
8wks
wild-derived RBRC
blood — clinical chemistry — electrolytes — potassium
metabolic panel
CGDpheno1
potassium (plasma K)
[mmol/L]
72
strains
age
10wks
Inbred
Eumorphia1
potassium (plasma K)
[mmol/L]
6
strains
age
12wks
Inbred
Yuan3
potassium (serum K) [mmol/L]
• 6mo
• 12mo
• 18mo
• age comparison
31
strains
ages shown
Inbred
Donahue9
potassium (serum K)
[mmol/L]
25
strains
age
11wks
B6.PWD consomic
Chesler2
potassium (blood K)
[mmol/L]
62
strains
age
various
CC diallel
Chesler3
potassium (blood K)
[mmol/L]
age
various
CC pre
blood — clinical chemistry — electrolytes — sodium
metabolic panel
CGDpheno1
sodium (plasma Na)
[mmol/L]
72
strains
age
10wks
Inbred
Eumorphia1
sodium (plasma Na)
[mmol/L]
6
strains
age
12wks
Inbred
Yuan3
sodium (serum Na) [mmol/L]
• 6mo
• 12mo
• 18mo
• age comparison
31
strains
ages shown
Inbred
Donahue9
sodium (serum Na)
[mmol/L]
25
strains
age
11wks
B6.PWD consomic
Chesler2
sodium (blood Na)
[mmol/L]
62
strains
age
various
CC diallel
Chesler3
sodium (blood Na)
[mmol/L]
age
various
CC pre
blood — clinical chemistry — enzymes — ALP
metabolic panel
Eumorphia1
alkaline phosphatase (plasma ALP)
[IU/L]
4
strains
age
12wks
Inbred
RIKEN-EAD1
alkaline phosphatase (plasma ALP)
[IU/L]
35
strains
age
8wks
Inbred
Yuan3
alkaline phosphatase (serum ALP) [IU/L]
• 6mo
• 12mo
• 18mo
• age comparison
31
strains
ages shown
Inbred
Donahue9
alkaline phosphatase (serum ALP)
[IU/L]
25
strains
age
11wks
B6.PWD consomic
RIKEN-EAD2
alkaline phosphatase (plasma ALP)
[IU/L]
26
strains
age
8wks
wild-derived RBRC
blood — clinical chemistry — enzymes — ALT
metabolic panel
Eumorphia1
alanine aminotransferase (plasma ALT)
[IU/L]
4
strains
age
12wks
Inbred
Harrill2
alanine aminotransferase (serum ALT) [IU/L] control and
DB289
• control
• DB289
• difference
34
strains
age
6-8wks
Inbred
Jaxpheno3
alanine aminotransferase (plasma ALT) [IU/L]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
Paigen1
alanine aminotransferase (plasma ALT)
[IU/L]
high-fat diet
8wks
43
strains
age
15-19wks
Inbred
RIKEN-EAD1
alanine aminotransferase (plasma ALT)
[IU/L]
35
strains
age
8wks
Inbred
Rusyn2
alanine aminotransferase (serum ALT), naive
[IU/L]
17
strains
age
7wks
Inbred
Rusyn2
alanine aminotransferase (serum ALT) [IU/L] control and
trichloroethylene
control group:
• 2h
• 8h
• 24h
• time comparison
treated group:
• 2h
• 8h
• 24h
• time comparison
17
strains
age
7wks
Inbred
Rusyn2
ALT, control vs. treated
trichloroethylene
2h
8h
24h
17
strains
age
7wks
Inbred
Rusyn5
serum alanine aminotransferase (ALT) [IU/L]
high-fat diet , ethanol
• high-fat only
• high-fat and ethanol
• comparison
14
strains
age
8-14wks
Inbred
Threadgill1
alanine aminotransferase (serum ALT) [IU/L] control and
acetaminophen
100 mg/kg:
• control
• 4h
• 12h
• 24h
• time comparison
37
strains
age
8-17wks
Inbred
Threadgill2
alanine aminotransferase (serum ALT) [IU/L]
acetaminophen
50mg/kg
• 50 mg/kg
• 300 mg/kg
• comparison
5
strains
age
6-8wks
Inbred
Yuan3
alanine animotransferase (plasma ALT) [IU/L]
• 6mo
• 12mo
• 18mo
• age comparison
32
strains
ages shown
Inbred
Donahue9
alanine aminotransferase (serum ALT)
[IU/L]
25
strains
age
11wks
B6.PWD consomic
Paigen3
alanine aminotransferase (plasma ALT)
[IU/L]
high-fat diet
8wks
8
strains
age
15-19wks
obesity mutants
RIKEN-EAD2
alanine aminotransferase (plasma ALT)
[IU/L]
26
strains
age
8wks
wild-derived RBRC
blood — clinical chemistry — enzymes — AST
metabolic panel
Eumorphia1
aspartate aminotransferase (plasma AST; SGOT)
[IU/L]
4
strains
age
12wks
Inbred
RIKEN-EAD1
aspartate aminotransferase (plasma AST)
[IU/L]
35
strains
age
8wks
Inbred
Rusyn2
aspartate aminotransferase (serum AST), naive
[IU/L]
17
strains
age
7wks
Inbred
Rusyn2
aspartate aminotransferase (serum AST) [IU/L] control and
trichloroethylene
control group:
• 2h
• 8h
• 24h
• time comparison
treated group:
• 2h
• 8h
• 24h
• time comparison
17
strains
age
7wks
Inbred
Rusyn2
AST, control vs. treated
trichloroethylene
2h
8h
24h
17
strains
age
7wks
Inbred
Threadgill1
aspartate aminotransferase (serum AST) [IU/L] control and
acetaminophen
• control
post-Rx mg/kg:
• 100
• 200
• 300
• comparison
37
strains
age
8-17wks
Inbred
Lake1
aspartate aminotransferase (plasma AST)
[mg/dL]
23
strains
age
8wks
B6.A consomic
Donahue9
aspartate aminotransferase (serum AST; SGOT)
[IU/L]
25
strains
age
11wks
B6.PWD consomic
Svenson3
aspartate aminotransferase (plasma AST)
[mg/dL]
21
strains
age
8wks
B6.PWD consomic
RIKEN-EAD2
aspartate aminotransferase (plasma AST)
[IU/L]
26
strains
age
8wks
wild-derived RBRC
blood — clinical chemistry — enzymes — misc
metabolic panel
Eumorphia1
creatine kinase (plasma CK)
[IU/L]
4
strains
age
12wks
Inbred
Eumorphia1
lactic acid dehydrogenase (plasma LDH)
[IU/L]
4
strains
age
12wks
Inbred
Eumorphia1
plasma alpha-amylase
[IU/L]
4
strains
age
12wks
Inbred
Jaxpheno3
creatine kinase (plasma CK) [IU/L]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
RIKEN-EAD1
lactate dehydrogenase (plasma LDH)
[IU/L]
35
strains
age
8wks
Inbred
RIKEN-EAD1
plasma amylase
[U/L]
35
strains
age
8wks
Inbred
Shockley1
glutamate dehydrogenase (GLDH) [IU/L] control and
high-fat diet
4wks
• control diet
• high-fat diet
• difference
• comparison
10
strains
age
10-13wks
Inbred
Yuan3
lipase (plasma LIP) [U/L]
• 6mo
• 12mo
• 18mo
• age comparison
32
strains
ages shown
Inbred
Donahue9
lipase (serum LIP)
[U/L]
25
strains
age
11wks
B6.PWD consomic
Donahue9
lactate dehydrogenase (serum LDH)
[U/L]
25
strains
age
11wks
B6.PWD consomic
RIKEN-EAD2
lactate dehydrogenase (plasma LDH)
[IU/L]
26
strains
age
8wks
wild-derived RBRC
RIKEN-EAD2
plasma amylase
[U/L]
26
strains
age
8wks
wild-derived RBRC
blood — clinical chemistry — gases
metabolic panel
CGDpheno1
dissolved-ionized carbon dioxide (CO
2
)
[mmol/L]
72
strains
age
10wks
Inbred
Yuan3
dissolved-ionized carbon dioxide (CO
2
) [mmol/L]
• 6mo
• 12mo
• 18mo
• age comparison
31
strains
ages shown
Inbred
Donahue9
dissolved-ionized carbon dioxide (serum CO
2
)
[mmol/L]
25
strains
age
11wks
B6.PWD consomic
Chesler2
carbon dioxide (blood CO
2
)
[mmol/L]
62
strains
age
various
CC diallel
Chesler3
carbon dioxide (blood CO
2
)
[mmol/L]
age
various
CC pre
blood — clinical chemistry — glucose
metabolic panel
CGDpheno1
glucose (plasma GLU, 4h fast)
[mg/dL]
72
strains
age
12wks
Inbred
Eumorphia1
glucose (plasma GLU, ??h fast)
[mg/dL]
6
strains
age
12wks
Inbred
Jaxpheno3
glucose (plasma GLU, 4h fast) [mg/dL]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
Naggert1
glucose (plasma GLU, 4h fast) [mg/dL] baseline and
high-fat diet
17wks
• baseline
• after 17wks on diet
• Δchange
• comparison
43
strains
age
7-9wks
at baseline
Inbred
RIKEN-EAD1
glucose (plasma GLU)
[mg/dL]
35
strains
age
8wks
Inbred
Schonfeld1
glucose (plasma GLU, non-fasted)
[mg/dL]
10
strains
age
9-13wks
Inbred
Shockley1
glucose (GLU) [mg/dL] control and
high-fat diet
4wks
• control diet
• high-fat diet
• difference
• comparison
10
strains
age
10-13wks
Inbred
Lake1
glucose (plasma GLU, 4h fast)
[mg/dL]
23
strains
age
8wks
B6.A consomic
Svenson3
glucose (plasma GLU, 4h fast)
[mg/dL]
27
strains
age
8wks
B6.PWD consomic
CGDpheno3
glucose (plasma GLU, 4h fast)
[mg/dL]
62
strains
age
8wks
CC diallel
Chesler2
glucose (blood GLU)
[mg/dL]
62
strains
age
various
CC diallel
Chesler2
glucose (blood GLU, overnight fast)
[mg/dL]
62
strains
age
various
CC diallel
Chesler3
glucose (blood GLU)
[mg/dL]
age
various
CC pre
Chesler3
glucose (blood GLU, overnight fast)
[mg/dL]
age
various
CC pre
RIKEN-EAD2
glucose (plasma GLU)
[mg/dL]
26
strains
age
8wks
wild-derived RBRC
blood — clinical chemistry — miscellaneous
metabolic panel
Paigen1
bile salts (plasma)
[µmol/L]
high-fat diet
8wks
43
strains
age
15-19wks
Inbred
Schonfeld1
beta-hydroxybutyrate (plasma BHB, 5h fast)
[mM]
10
strains
age
9-13wks
Inbred
Tordoff3
blood pH
[pH]
40
strains
age
13-15wks
Inbred
Paigen3
bile salts (plasma)
[µmol/L]
high-fat diet
8wks
8
strains
age
15-19wks
obesity mutants
blood — clinical chemistry — proteins
metabolic panel
Harrill2
creatinine (serum CREA) [mg/dL] control and
DB289
• control
• DB289
• difference
34
strains
age
6-8wks
Inbred
blood — clinical chemistry — proteins — albumin
metabolic panel
Eumorphia1
albumin (plasma Alb)
[g/dL]
6
strains
age
12wks
Inbred
Jaxpheno3
albumin (Alb) [g/dL]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
RIKEN-EAD1
albumin (plasma Alb)
[g/dL]
35
strains
age
8wks
Inbred
Yuan3
albumin (plasma Alb) [g/dL]
• 6mo
• 12mo
• 18mo
• age comparison
32
strains
ages shown
Inbred
Donahue9
albumin (serum Alb)
[g/dL]
25
strains
age
11wks
B6.PWD consomic
RIKEN-EAD2
albumin (plasma Alb)
[g/dL]
26
strains
age
8wks
wild-derived RBRC
blood — clinical chemistry — proteins — creatinine
metabolic panel
Eumorphia1
plasma creatinine
[mg/dL]
6
strains
age
12wks
Inbred
RIKEN-EAD1
plasma creatinine
[mg/dL]
35
strains
age
8wks
Inbred
Donahue9
serum creatinine
[mg/dL]
25
strains
age
11wks
B6.PWD consomic
Chesler2
creatinine (blood)
[mg/dL]
62
strains
age
various
CC diallel
Chesler3
creatinine (blood)
[mg/dL]
age
various
CC pre
RIKEN-EAD2
plasma creatinine
[mg/dL]
26
strains
age
8wks
wild-derived RBRC
blood — clinical chemistry — proteins — misc
metabolic panel
Eumorphia1
plasma ferritin
[mg/mL]
4
strains
age
12wks
Inbred
Eumorphia1
plasma transferrin
[mg/mL]
4
strains
age
12wks
Inbred
blood — clinical chemistry — proteins — total
metabolic panel
Eumorphia1
total protein (plasma TP)
[g/dL]
6
strains
age
12wks
Inbred
Jaxpheno3
total protein (TP) [g/dL]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
RIKEN-EAD1
total protein (plasma TP)
[g/dL]
35
strains
age
8wks
Inbred
Yuan3
total protein (plasma TP) [g/dL]
• 6mo
• 12mo
• 18mo
• age comparison
32
strains
ages shown
Inbred
Donahue9
total protein (serum TP)
[g/dL]
25
strains
age
11wks
B6.PWD consomic
RIKEN-EAD2
total protein (plasma TP)
[g/dL]
26
strains
age
8wks
wild-derived RBRC
blood — clinical chemistry — urea nitrogen
metabolic panel
CGDpheno1
blood urea nitrogen (BUN)
[mg/dL]
72
strains
age
12wks
Inbred
Eumorphia1
blood urea nitrogen (BUN)
[mg/dL]
6
strains
age
12wks
Inbred
Harrill2
blood urea nitrogen (serum BUN) [mg/dL] control and
DB289
• control
• DB289
• difference
34
strains
age
6-8wks
Inbred
Jaxpheno3
blood urea nitrogen (BUN) [mg/dL]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
RIKEN-EAD1
blood urea nitrogen (plasma BUN)
[mg/dL]
35
strains
age
8wks
Inbred
Rusyn2
blood urea nitrogen (serum BUN), naive
[mg/dL]
17
strains
age
7wks
Inbred
Rusyn2
blood urea nitrogen (serum BUN) [mg/dL] control and
trichloroethylene
control group:
• 2h
• 8h
• 24h
• time comparison
treated group:
• 2h
• 8h
• 24h
• time comparison
17
strains
age
7wks
Inbred
Rusyn2
blood urea nitrogen (BUN), control vs. treated
trichloroethylene
2h
8h
24h
17
strains
age
7wks
Inbred
Shockley1
blood urea nitrogen (BUN) [mg/dL] control and
high-fat diet
4wks
• control diet
• high-fat diet
• difference
• comparison
10
strains
age
10-13wks
Inbred
Threadgill1
blood urea nitrogen (BUN) [mg/dL] control and
acetaminophen
• control
post-Rx mg/kg:
• 100
• 200
• 300
• comparison
36
strains
age
8-17wks
Inbred
Yuan3
blood urea nitrogen (plasma BUN) [mg/dL]
• 6mo
• 12mo
• 18mo
• age comparison
31
strains
ages shown
Inbred
Donahue9
blood urea nitrogen (serum BUN)
[mg/dL]
25
strains
age
11wks
B6.PWD consomic
Svenson3
blood urea nitrogen (plasma BUN)
[mg/dL]
9
strains
age
8wks
B6.PWD consomic
Chesler2
blood urea nitrogen (BUN)
[mg/dL]
62
strains
age
various
CC diallel
Chesler3
blood urea nitrogen (BUN)
[mg/dL]
age
various
CC pre
RIKEN-EAD2
blood urea nitrogen (plasma BUN)
[mg/dL]
26
strains
age
8wks
wild-derived RBRC
blood — clinical chemistry — uric acid
metabolic panel
Eumorphia1
plasma uric acid
[mg/dL]
4
strains
age
12wks
Inbred
RIKEN-EAD1
plasma uric acid
[mg/dL]
35
strains
age
8wks
Inbred
RIKEN-EAD2
plasma uric acid
[mg/dL]
26
strains
age
8wks
wild-derived RBRC
endocrine — hormones — thyroxine
metabolic panel
CGDpheno1
thyroxine (plasma T4)
[µg/dL]
72
strains
age
12wks
Inbred
Donahue1
thyroxine (serum T4)
[µg/dL]
30
strains
age
15-16wks
Inbred
Jaxpheno3
thyroxine (plasma T4) [µg/dL]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
Shockley1
thyroxine (T4) [µg/dL] control and
high-fat diet
4wks
• control diet
• high-fat diet
• difference
• comparison
10
strains
age
10-13wks
Inbred
Yuan3
thyroxine (serum T4) [µg/dL]
• 6mo
• 12mo
• 18mo
• age comparison
31
strains
ages shown
Inbred
liver — enzyme homeostasis
metabolic panel
Threadgill1
catalase [µg/mL] control and
acetaminophen
300 mg/kg
• control
• post-Rx 300 mg/kg
• comparison
36
strains
age
8-12wks
Inbred
247 measurements listed.
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