Home       About             Help       Phenotype data > FVB/NJ strain > interventions > trichloroethylene (industrial contaminant)   See also:   Wikipedia Measurements: About these FVB/NJ averages (♀ ♂) Exit FVB/NJ mode blood — clinical chemistry — enzymes — ALT         metabolic panel   Rusyn2 alanine aminotransferase (serum ALT) [IU/L]     control and  trichloroethylene       control group:             • 2h  ...... 59.3 (N=3)               • 8h  ...... 62.2 (N=3)               • 24h  ...... 25.2 (N=3)                 • time comparison         treated group:             • 2h  ...... 85.8 (N=3)               • 8h  ...... 93.9 (N=3)               • 24h  ...... 73.2 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 ALT, control vs. treated   trichloroethylene         2h        8h        24h        17 strains   age 7wks   Inbred   blood — clinical chemistry — enzymes — AST         metabolic panel   Rusyn2 aspartate aminotransferase (serum AST) [IU/L]     control and  trichloroethylene       control group:             • 2h  ...... 169 (N=3)               • 8h  ...... 125 (N=3)               • 24h  ...... 119 (N=3)                 • time comparison         treated group:             • 2h  ...... 134 (N=3)               • 8h  ...... 135 (N=3)               • 24h  ...... 141 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 AST, control vs. treated   trichloroethylene         2h        8h        24h        17 strains   age 7wks   Inbred   blood — clinical chemistry — urea nitrogen         metabolic panel   Rusyn2 blood urea nitrogen (serum BUN) [mg/dL]     control and  trichloroethylene       control group:             • 2h  ...... 22.3 (N=3)               • 8h  ...... 22.0 (N=3)               • 24h  ...... 20.3 (N=3)                 • time comparison         treated group:             • 2h  ...... 20.0 (N=3)               • 8h  ...... 23.0 (N=3)               • 24h  ...... 21.0 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 blood urea nitrogen (BUN), control vs. treated   trichloroethylene         2h        8h        24h        17 strains   age 7wks   Inbred   blood — xenobiotics — drug and metabolite concentration         HPLC   Rusyn2 dichloroacetic acid (serum DCA x 10-3) [nmol/mL]   trichloroethylene         treated group:             • 2h  ...... 26.7 (N=3)               • 8h  ...... 86.7 (N=3)               • 24h  ...... 60.0 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 trichloroacetic acid (serum TCA) [nmol/mL]   trichloroethylene         treated group:             • 2h  ...... 266 (N=3)               • 8h  ...... 1158 (N=3) ▲               • 24h  ...... 81.5 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 DCV cysteine (serum DCVC x 10-3) [nmol/mL]   trichloroethylene         treated group:             • 2h  ...... 2.14 (N=3) ▲               • 8h  ...... 0.500 (N=2) ▼               • 24h  ...... 0.490 (N=1) ▼                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 DCV glutathione (serum DCVG x 10-3) [nmol/mL]   trichloroethylene         treated group:             • 2h  ...... 17.4 (N=3)               • 8h  ...... 0.269 (N=3)               • 24h  ...... 0.114 (N=1)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 above metabolites compared   trichloroethylene         treated group:             2h              8h              24h              17 strains   age 7wks   Inbred   local experiment parameter   Rusyn2 body weight [g]     control and  trichloroethylene       control group:             • 2h  ...... 23.6 (N=3)               • 8h  ...... 23.1 (N=3)               • 24h  ...... 24.0 (N=3)                 • time comparison         treated group:             • 2h  ...... 24.2 (N=3)               • 8h  ...... 23.5 (N=3)               • 24h  ...... 23.5 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 body weight, control vs. treated   trichloroethylene         2h        8h        24h        17 strains   age 7wks   Inbred Rusyn2 liver weight as a percentage of body weight [ratio]     control and  trichloroethylene       control group:             • 2h  ...... 5.67 (N=3)               • 8h  ...... 5.07 (N=3)               • 24h  ...... 3.50 (N=3) ▼                 • time comparison         treated group:             • 2h  ...... 4.80 (N=3)               • 8h  ...... 5.13 (N=3)               • 24h  ...... 4.00 (N=3) ▼▼                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 adjusted liver weight, control vs. treated   trichloroethylene         2h        8h        24h        17 strains   age 7wks   Inbred

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