Home       About             Help       Phenotype data > C3H/HeJ strain > interventions > trichloroethylene (industrial contaminant)   See also:   Wikipedia Measurements: About these C3H/HeJ averages (♀ ♂) Exit C3H/HeJ mode blood — clinical chemistry — enzymes — ALT         metabolic panel   Rusyn2 alanine aminotransferase (serum ALT) [IU/L]     control and  trichloroethylene       control group:             • 2h  ...... 45.9 (N=3)               • 8h  ...... 32.9 (N=3)               • 24h  ...... 67.1 (N=3)                 • time comparison         treated group:             • 2h  ...... 58.8 (N=3)               • 8h  ...... 39.5 (N=3)               • 24h  ...... 75.8 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 ALT, control vs. treated   trichloroethylene         2h        8h        24h        17 strains   age 7wks   Inbred   blood — clinical chemistry — enzymes — AST         metabolic panel   Rusyn2 aspartate aminotransferase (serum AST) [IU/L]     control and  trichloroethylene       control group:             • 2h  ...... 217 (N=3)               • 8h  ...... 111 (N=3)               • 24h  ...... 231 (N=3)                 • time comparison         treated group:             • 2h  ...... 203 (N=3)               • 8h  ...... 96.0 (N=3)               • 24h  ...... 261 (N=3) ▲                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 AST, control vs. treated   trichloroethylene         2h        8h        24h        17 strains   age 7wks   Inbred   blood — clinical chemistry — urea nitrogen         metabolic panel   Rusyn2 blood urea nitrogen (serum BUN) [mg/dL]     control and  trichloroethylene       control group:             • 2h  ...... 18.0 (N=3)               • 8h  ...... 22.7 (N=3)               • 24h  ...... 15.3 (N=3) ▼                 • time comparison         treated group:             • 2h  ...... 17.0 (N=3)               • 8h  ...... 21.0 (N=3)               • 24h  ...... 14.3 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 blood urea nitrogen (BUN), control vs. treated   trichloroethylene         2h        8h        24h        17 strains   age 7wks   Inbred   blood — xenobiotics — drug and metabolite concentration         HPLC   Rusyn2 dichloroacetic acid (serum DCA x 10-3) [nmol/mL]   trichloroethylene         treated group:             • 2h  ...... 53.3 (N=3)               • 8h  ...... 480 (N=3)               • 24h  ...... 13.3 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 trichloroacetic acid (serum TCA) [nmol/mL]   trichloroethylene         treated group:             • 2h  ...... 243 (N=3)               • 8h  ...... 465 (N=3)               • 24h  ...... 168 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 DCV cysteine (serum DCVC x 10-3) [nmol/mL]   trichloroethylene         treated group:             • 2h  ...... 1.34 (N=3)               • 8h  ......             • 24h  ...... 1.13 (N=1)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 DCV glutathione (serum DCVG x 10-3) [nmol/mL]   trichloroethylene         treated group:             • 2h  ...... 21.2 (N=3)               • 8h  ...... 0.140 (N=3)               • 24h  ...... 0.0815 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 above metabolites compared   trichloroethylene         treated group:             2h              8h              24h              17 strains   age 7wks   Inbred   local experiment parameter   Rusyn2 body weight [g]     control and  trichloroethylene       control group:             • 2h  ...... 23.4 (N=3)               • 8h  ...... 20.1 (N=3)               • 24h  ...... 23.8 (N=3)                 • time comparison         treated group:             • 2h  ...... 24.0 (N=3)               • 8h  ...... 22.5 (N=3)               • 24h  ...... 22.2 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 body weight, control vs. treated   trichloroethylene         2h        8h        24h        17 strains   age 7wks   Inbred Rusyn2 liver weight as a percentage of body weight [ratio]     control and  trichloroethylene       control group:             • 2h  ...... 5.17 (N=3)               • 8h  ...... 5.00 (N=3)               • 24h  ...... 5.47 (N=3)                 • time comparison         treated group:             • 2h  ...... 4.87 (N=3)               • 8h  ...... 5.07 (N=3)               • 24h  ...... 5.43 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 adjusted liver weight, control vs. treated   trichloroethylene         2h        8h        24h        17 strains   age 7wks   Inbred

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