Home       About             Help       Phenotype data > 129S1/SvImJ strain > interventions > trichloroethylene (industrial contaminant)   See also:   Wikipedia Measurements: About these 129S1/SvImJ averages (♀ ♂) Exit 129S1/SvImJ mode blood — clinical chemistry — enzymes — ALT         metabolic panel   Rusyn2 alanine aminotransferase (serum ALT) [IU/L]     control and  trichloroethylene       control group:             • 2h  ...... 30.4 (N=3) ▼               • 8h  ...... 43.1 (N=3)               • 24h  ...... 21.2 (N=3)                 • time comparison         treated group:             • 2h  ...... 27.4 (N=3)               • 8h  ...... 34.5 (N=3)               • 24h  ...... 86.9 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 ALT, control vs. treated   trichloroethylene         2h        8h        24h        17 strains   age 7wks   Inbred   blood — clinical chemistry — enzymes — AST         metabolic panel   Rusyn2 aspartate aminotransferase (serum AST) [IU/L]     control and  trichloroethylene       control group:             • 2h  ...... 79.7 (N=3)               • 8h  ...... 94.7 (N=3)               • 24h  ...... 64.7 (N=3) ▼                 • time comparison         treated group:             • 2h  ...... 117 (N=3)               • 8h  ...... 130 (N=3)               • 24h  ...... 146 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 AST, control vs. treated   trichloroethylene         2h        8h        24h        17 strains   age 7wks   Inbred   blood — clinical chemistry — urea nitrogen         metabolic panel   Rusyn2 blood urea nitrogen (serum BUN) [mg/dL]     control and  trichloroethylene       control group:             • 2h  ...... 22.0 (N=3)               • 8h  ...... 24.3 (N=3)               • 24h  ...... 17.7 (N=3)                 • time comparison         treated group:             • 2h  ...... 22.0 (N=3)               • 8h  ...... 19.3 (N=3)               • 24h  ...... 15.0 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 blood urea nitrogen (BUN), control vs. treated   trichloroethylene         2h        8h        24h        17 strains   age 7wks   Inbred   blood — xenobiotics — drug and metabolite concentration         HPLC   Rusyn2 dichloroacetic acid (serum DCA x 10-3) [nmol/mL]   trichloroethylene         treated group:             • 2h  ...... 30.0 (N=2)               • 8h  ...... 13.3 (N=3)               • 24h  ...... 170 (N=2) ▲                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 trichloroacetic acid (serum TCA) [nmol/mL]   trichloroethylene         treated group:             • 2h  ...... 213 (N=2) ▼               • 8h  ...... 504 (N=3)               • 24h  ...... 413 (N=2) ▲▲                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 DCV cysteine (serum DCVC x 10-3) [nmol/mL]   trichloroethylene         treated group:             • 2h  ...... 1.90 (N=2)               • 8h  ...... 3.11 (N=1) ▲               • 24h  ......               • time comparison   17 strains   age 7wks   Inbred Rusyn2 DCV glutathione (serum DCVG x 10-3) [nmol/mL]   trichloroethylene         treated group:             • 2h  ...... 2.69 (N=2)               • 8h  ...... 1.87 (N=3)               • 24h  ...... 0.108 (N=2)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 above metabolites compared   trichloroethylene         treated group:             2h              8h              24h              17 strains   age 7wks   Inbred   local experiment parameter   Rusyn2 body weight [g]     control and  trichloroethylene       control group:             • 2h  ...... 22.3 (N=3)               • 8h  ...... 19.7 (N=3)               • 24h  ...... 15.7 (N=3)                 • time comparison         treated group:             • 2h  ...... 19.9 (N=3)               • 8h  ...... 25.2 (N=3)               • 24h  ...... 21.5 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 body weight, control vs. treated   trichloroethylene         2h        8h        24h        17 strains   age 7wks   Inbred Rusyn2 liver weight as a percentage of body weight [ratio]     control and  trichloroethylene       control group:             • 2h  ...... 3.80 (N=3) ▼               • 8h  ...... 3.73 (N=3) ▼               • 24h  ...... 7.67 (N=3) ▲                 • time comparison         treated group:             • 2h  ...... 4.70 (N=3)               • 8h  ...... 3.20 (N=2) ▼               • 24h  ...... 4.87 (N=3) ▼                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 adjusted liver weight, control vs. treated   trichloroethylene         2h        8h        24h        17 strains   age 7wks   Inbred

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