Home       About             Help       Phenotype data > BTBR T+ tf/J strain > interventions > trichloroethylene (industrial contaminant)   See also:   Wikipedia Measurements: About these BTBR T+ tf/J averages (♀ ♂) Exit BTBR T+ tf/J mode blood — clinical chemistry — enzymes — ALT         metabolic panel   Rusyn2 alanine aminotransferase (serum ALT) [IU/L]     control and  trichloroethylene       control group:             • 2h  ...... 41.5 (N=3)               • 8h  ...... 27.9 (N=3)               • 24h  ...... 21.8 (N=3)                 • time comparison         treated group:             • 2h  ...... 31.1 (N=3)               • 8h  ...... 32.9 (N=3)               • 24h  ...... 39.1 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 ALT, control vs. treated   trichloroethylene       2h        8h        24h        17 strains   age 7wks   Inbred   blood — clinical chemistry — enzymes — AST         metabolic panel   Rusyn2 aspartate aminotransferase (serum AST) [IU/L]     control and  trichloroethylene       control group:             • 2h  ...... 143 (N=3)               • 8h  ...... 83.3 (N=3)               • 24h  ...... 53.3 (N=3) ▼                 • time comparison         treated group:             • 2h  ...... 102 (N=3) ▼               • 8h  ...... 85.0 (N=3)               • 24h  ...... 56.0 (N=3) ▼                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 AST, control vs. treated   trichloroethylene       2h        8h        24h        17 strains   age 7wks   Inbred   blood — clinical chemistry — urea nitrogen         metabolic panel   Rusyn2 blood urea nitrogen (serum BUN) [mg/dL]     control and  trichloroethylene       control group:             • 2h  ...... 13.3 (N=3) ▼               • 8h  ...... 17.7 (N=3) ▼               • 24h  ...... 21.0 (N=3)                 • time comparison         treated group:             • 2h  ...... 16.7 (N=3)               • 8h  ...... 15.7 (N=3)               • 24h  ...... 22.0 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 blood urea nitrogen (BUN), control vs. treated   trichloroethylene       2h        8h        24h        17 strains   age 7wks   Inbred   blood — xenobiotics — drug and metabolite concentration         HPLC   Rusyn2 dichloroacetic acid (serum DCA x 10-3) [nmol/mL]   trichloroethylene       treated group:             • 2h  ...... 26.7 (N=3)               • 8h  ...... 2410 (N=3) ▲▲               • 24h  ...... 10.0 (N=1)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 trichloroacetic acid (serum TCA) [nmol/mL]   trichloroethylene       treated group:             • 2h  ...... 252 (N=3)               • 8h  ...... 417 (N=3)               • 24h  ...... 136 (N=2)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 DCV cysteine (serum DCVC x 10-3) [nmol/mL]   trichloroethylene       treated group:             • 2h  ...... 0.571 (N=3) ▼               • 8h  ...... 1.91 (N=2)               • 24h  ......               • time comparison   17 strains   age 7wks   Inbred Rusyn2 DCV glutathione (serum DCVG x 10-3) [nmol/mL]   trichloroethylene       treated group:             • 2h  ...... 5.71 (N=3)               • 8h  ...... 1.13 (N=3)               • 24h  ...... 0.0630 (N=1)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 above metabolites compared   trichloroethylene       treated group:             2h              8h              24h              17 strains   age 7wks   Inbred   local experiment parameter   Rusyn2 body weight [g]     control and  trichloroethylene       control group:             • 2h  ...... 29.9 (N=3) ▲               • 8h  ...... 29.0 (N=3) ▲               • 24h  ...... 28.7 (N=3) ▲                 • time comparison         treated group:             • 2h  ...... 28.7 (N=3) ▲               • 8h  ...... 30.4 (N=3) ▲               • 24h  ...... 27.9 (N=3) ▲                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 body weight, control vs. treated   trichloroethylene       2h        8h        24h        17 strains   age 7wks   Inbred Rusyn2 liver weight as a percentage of body weight [ratio]     control and  trichloroethylene       control group:             • 2h  ...... 5.00 (N=3)               • 8h  ...... 4.83 (N=3)               • 24h  ...... 5.23 (N=3)                 • time comparison         treated group:             • 2h  ...... 5.70 (N=3)               • 8h  ...... 4.73 (N=3)               • 24h  ...... 5.93 (N=3)                 • time comparison   17 strains   age 7wks   Inbred Rusyn2 adjusted liver weight, control vs. treated   trichloroethylene       2h        8h        24h        17 strains   age 7wks   Inbred

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