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Phenotype data > MPD - Phenotype data: trichloroethylene interventions >
trichloroethylene
((TCE) industrial contaminant)
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  gene expression microarray data
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blood — clinical chemistry — enzymes — ALT         metabolic panel  
Rusyn2
alanine aminotransferase (serum ALT) [IU/L]     control and  trichloroethylene      
  control group:    • 2h    • 8h    • 24h      time comparison        
  treated group:    • 2h    • 8h    • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
ALT, control vs. treated   trichloroethylene      
2h  8h  24h 
17 strains   age 7wks
  Inbred
 
blood — clinical chemistry — enzymes — AST         metabolic panel  
Rusyn2
aspartate aminotransferase (serum AST) [IU/L]     control and  trichloroethylene      
  control group:    • 2h    • 8h    • 24h      time comparison        
  treated group:    • 2h    • 8h    • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
AST, control vs. treated   trichloroethylene      
2h  8h  24h 
17 strains   age 7wks
  Inbred
 
blood — clinical chemistry — urea nitrogen         metabolic panel  
Rusyn2
blood urea nitrogen (serum BUN) [mg/dL]     control and  trichloroethylene      
  control group:    • 2h    • 8h    • 24h      time comparison        
  treated group:    • 2h    • 8h    • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
blood urea nitrogen (BUN), control vs. treated   trichloroethylene      
2h  8h  24h 
17 strains   age 7wks
  Inbred
Rusyn6
blood urea nitrogen (serum BUN) [mg/dL]     control and  trichloroethylene      
• control  • TCE      comparison  
7 strains   age 6-7wks
  Inbred
 
blood — xenobiotics — drug and metabolite concentration         HPLC  
Rusyn2
dichloroacetic acid (serum DCA x 10-3) [nmol/mL]   trichloroethylene      
treated group:  • 2h  • 8h  • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
trichloroacetic acid (serum TCA) [nmol/mL]   trichloroethylene      
treated group:  • 2h  • 8h  • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
DCV cysteine (serum DCVC x 10-3) [nmol/mL]   trichloroethylene      
treated group:  • 2h  • 8h  • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
DCV glutathione (serum DCVG x 10-3) [nmol/mL]   trichloroethylene      
treated group:  • 2h  • 8h  • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
above metabolites compared   trichloroethylene      
treated group:  2h  8h  24h 
17 strains   age 7wks
  Inbred
 
blood — xenobiotics — drug and metabolite concentration         HPLC/MS  
Rusyn6
trichloroacetic acid (serum TCA)   [nmol/mL]   trichloroethylene 7 strains   age 6-7wks
  Inbred
Rusyn6
dichloroacetic acid (serum DCA)   [nmol/mL]   trichloroethylene 7 strains   age 6-7wks
  Inbred
Rusyn6
S-(1,2-dichlorovinyl) glutathione (serum DCVG)   [pmol/mL]   trichloroethylene 7 strains   age 6-7wks
  Inbred
Rusyn6
S-(1,2-dichlorovinyl)-L-cysteine (serum DCVC)   [pmol/mL]   trichloroethylene 7 strains   age 6-7wks
  Inbred
 
kidney — gene expression         RT-PCR  
Rusyn6
Acox1, mRNA in kidney, relative to control group   [ratio]   trichloroethylene   gene info: Acox1 7 strains   age 6-7wks
  Inbred
Rusyn6
Cyp4a10, mRNA in kidney, relative to control group   [ratio]   trichloroethylene   gene info: Cyp4a10 7 strains   age 6-7wks
  Inbred
Rusyn6
Ppara, mRNA in kidney, relative to control group   [ratio]   trichloroethylene   gene info: Ppara 7 strains   age 6-7wks
  Inbred
 
kidney — morphology — weight         scales  
Rusyn6
kidney weight as a percent of body weight [%]     control and  trichloroethylene      
• control  • TCE      comparison  
7 strains   age 6-7wks
  Inbred
 
kidney — pathology         histopathology  
Rusyn6
BrdU-positive nuclei in kidney (proximal tubule cell proliferation), relative to control group   [%]   trichloroethylene 7 strains   age 6-7wks
  Inbred
Rusyn6
kidney injury molecule 1 (KIM-1) positive proximal tubules [%]     control and  trichloroethylene      
• control  • TCE      comparison  
7 strains   age 6-7wks
  Inbred
 
kidney — xenobiotics — drug and metabolite concentration         GC/MS  
Rusyn6
trichloroethanol (kidney TCOH)   [nmol/g]   trichloroethylene 7 strains   age 6-7wks
  Inbred
 
kidney — xenobiotics — drug and metabolite concentration         HPLC/MS  
Rusyn6
trichloroacetic acid (kidney TCA)   [nmol/g]   trichloroethylene 7 strains   age 6-7wks
  Inbred
Rusyn6
dichloroacetic acid (kidney DCA)   [nmol/g]   trichloroethylene 7 strains   age 6-7wks
  Inbred
Rusyn6
S-(1,2-dichlorovinyl) glutathione (kidney DCVG)   [pmol/g]   trichloroethylene 7 strains   age 6-7wks
  Inbred
Rusyn6
S-(1,2-dichlorovinyl)-L-cysteine (kidney DCVC)   [pmol/g]   trichloroethylene 7 strains   age 6-7wks
  Inbred
 
liver — gene expression         RT-PCR  
Rusyn6
Acox1, mRNA in liver, relative to control group   [ratio]   trichloroethylene   gene info: Acox1 7 strains   age 6-7wks
  Inbred
Rusyn6
Cyp4a10, mRNA in liver, relative to control group   [ratio]   trichloroethylene   gene info: Cyp4a10 7 strains   age 6-7wks
  Inbred
Rusyn6
Ppara, mRNA in liver, relative to control group   [ratio]   trichloroethylene   gene info: Ppara 7 strains   age 6-7wks
  Inbred
 
liver — pathology         histopathology  
Rusyn6
BrdU-positive nuclei in liver (hepatocellular proliferation), relative to control group   [%]   trichloroethylene 7 strains   age 6-7wks
  Inbred
 
liver — weight         scales  
Rusyn6
liver weight as a percent of body weight [%]     control and  trichloroethylene      
• control  • TCE      comparison  
7 strains   age 6-7wks
  Inbred
 
liver — xenobiotics — drug and metabolite concentration         GC/MS  
Rusyn6
trichloroethanol (liver TCOH)   [nmol/g]   trichloroethylene 7 strains   age 6-7wks
  Inbred
 
liver — xenobiotics — drug and metabolite concentration         HPLC/MS  
Rusyn6
trichloroacetic acid (liver TCA)   [nmol/g]   trichloroethylene 7 strains   age 6-7wks
  Inbred
Rusyn6
dichloroacetic acid (liver DCA)   [nmol/g]   trichloroethylene 7 strains   age 6-7wks
  Inbred
Rusyn6
S-(1,2-dichlorovinyl) glutathione (liver DCVG)   [pmol/g]   trichloroethylene 7 strains   age 6-7wks
  Inbred
 
local experiment parameter  
Rusyn2
body weight [g]     control and  trichloroethylene      
  control group:    • 2h    • 8h    • 24h      time comparison        
  treated group:    • 2h    • 8h    • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
body weight, control vs. treated   trichloroethylene      
2h  8h  24h 
17 strains   age 7wks
  Inbred
Rusyn2
liver weight as a percentage of body weight [%]     control and  trichloroethylene      
  control group:    • 2h    • 8h    • 24h      time comparison        
  treated group:    • 2h    • 8h    • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
adjusted liver weight, control vs. treated   trichloroethylene      
2h  8h  24h 
17 strains   age 7wks
  Inbred


 


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