|
respiratory — airway resistance
ventilator
|
|
|
|
resistance
[cm/mL/s]
| baseline and
|
methacholine
|
|
......
0.260
0.350
MCh challenge (mg/mL):
......
0.300
0.403
......
0.387
0.672
......
0.866
1.35
......
1.52
2.13
|
Inbred
|
|
|
|
resistance (percent of baseline)
[%]
|
methacholine
|
|
MCh challenge (mg/mL):
......
15.7
14.9
......
49.1
91.9
......
243
290
......
545
520
|
Inbred
|
|
|
|
airway resistance (H20 pressure)
[cm/mL/s]
| baseline and
|
methacholine
|
|
......
0.260
0.350
MCh [mg/mL]:
......
0.300
0.403
......
0.387
0.672
......
0.866
1.35
......
1.52
2.13
......
0.497
0.545
|
Inbred
|
| |
|
respiratory — breathing pattern — airflow rate
plethysmography
|
|
|
|
inspiratory flow rate
[mL/kg/s]
| baseline and
|
methacholine
|
|
......
3.26
3.64
MCh [mg/mL]:
......
2.89
2.90
......
1.43
2.04
......
3.61
3.72
......
0.166
0.191
|
Inbred
|
|
|
|
expiratory flow rate
[mL/kg/s]
| baseline and
|
methacholine
|
|
......
1.39
1.26
MCh [mg/mL]:
......
1.15
1.21
......
1.43
2.04
......
2.31
2.62
......
0.482
0.567
|
Inbred
|
|
|
|
respiratory flow rate
[mL/kg/s]
| baseline and
|
methacholine
|
|
......
0.958
0.931
MCh [mg/mL]:
......
0.821
0.853
......
0.968
1.28
......
1.39
1.54
......
0.375
0.436
|
Inbred
|
| |
|
respiratory — breathing pattern — cycle
plethysmography
|
|
|
|
inspiratory phase
[s]
| baseline and
|
methacholine
|
|
......
0.0779
0.0722
MCh [mg/mL]:
......
0.0785
0.0791
......
0.0761
0.0790
......
0.0883
0.104
......
0.0815
0.197
|
Inbred
|
|
|
|
expiratory phase
[s]
| baseline and
|
methacholine
|
|
......
0.198
0.212
MCh [mg/mL]:
......
0.199
0.190
......
0.163
0.149
......
0.143
0.149
......
-0.235
-0.180
|
Inbred
|
|
|
|
respiratory cycle
[s]
| baseline and
|
methacholine
|
|
......
0.276
0.284
MCh [mg/mL]:
......
0.277
0.269
......
0.239
0.228
......
0.232
0.253
......
-0.128
-0.0477
|
Inbred
|
|
|
|
duty cycle
[ratio]
| baseline and
|
methacholine
|
|
......
0.293
0.260
MCh [mg/mL]:
......
0.286
0.295
......
0.320
0.355
......
0.383
0.413
......
0.209
0.245
|
Inbred
|
| |
|
respiratory — breathing pattern — efficiency
plethysmography
|
|
|
|
minute ventilation
[mL/min]
| baseline and
|
methacholine
|
|
......
64.7
62.9
MCh [mg/mL]:
......
52.8
54.3
......
61.9
79.1
......
88.5
94.1
......
0.372
0.406
|
Inbred
|
|
|
|
breath frequency
[n/min]
| baseline and
|
methacholine
|
|
......
264
244
MCh [mg/mL]:
......
249
247
......
276
292
......
278
250
......
0.0819
0.00637
|
Inbred
|
| |
|
respiratory — breathing pattern — enhanced pause
plethysmography
|
|
|
|
enhanced pause
| baseline and
|
methacholine
|
|
......
0.718
0.479
MCh [mg/mL]:
......
0.560
0.827
......
0.773
2.20
......
3.60
5.41
......
1.14
1.35
|
Inbred
|
| |
|
respiratory — lung compliance
ventilator
|
|
|
|
lung tissue dynamic elastance (H20 pressure)
[cm/mL]
| baseline and
|
methacholine
|
|
......
55.1
47.6
MCh [mg/mL]:
......
56.0
51.9
......
65.5
58.5
......
74.9
71.1
......
96.8
87.7
......
0.142
0.154
|
Inbred
|
| |
|
respiratory — lung volume
plethysmography
|
|
|
|
tidal volume
[mL]
| baseline and
|
methacholine
|
|
......
0.250
0.263
MCh [mg/mL]:
......
0.220
0.222
......
0.228
0.259
......
0.314
0.379
......
0.247
0.388
|
Inbred
|