|
respiratory — airway resistance
ventilator
|
|
|
|
resistance
[cm/mL/s]
| baseline and
|
methacholine
|
|
......
0.417
0.499
MCh challenge (mg/mL):
......
0.544
0.594
......
0.744
0.738
......
1.25
1.14
......
2.04
2.37
|
Inbred
|
|
|
|
resistance (percent of baseline)
[%]
|
methacholine
|
|
MCh challenge (mg/mL):
......
30.1
18.7
......
76.8
47.1
......
204
128
......
392
378
|
Inbred
|
|
|
|
airway resistance (H20 pressure)
[cm/mL/s]
| baseline and
|
methacholine
|
|
......
0.417
0.499
MCh [mg/mL]:
......
0.544
0.594
......
0.744
0.738
......
1.25
1.14
......
2.04
2.37
......
0.396
0.399
|
Inbred
|
| |
|
respiratory — breathing pattern — airflow rate
plethysmography
|
|
|
|
inspiratory flow rate
[mL/kg/s]
| baseline and
|
methacholine
|
|
......
3.69
3.54
MCh [mg/mL]:
......
2.37
2.56
......
0.936
1.31
......
2.47
2.42
......
0.0225
-0.0391
|
Inbred
|
|
|
|
expiratory flow rate
[mL/kg/s]
| baseline and
|
methacholine
|
|
......
1.87
1.64
MCh [mg/mL]:
......
1.07
1.26
......
0.936
1.31
......
1.39
1.35
......
0.194
0.0699
|
Inbred
|
|
|
|
respiratory flow rate
[mL/kg/s]
| baseline and
|
methacholine
|
|
......
1.23
1.12
MCh [mg/mL]:
......
0.732
0.832
......
0.636
0.872
......
0.890
0.867
......
0.137
0.0372
|
Inbred
|
| |
|
respiratory — breathing pattern — cycle
plethysmography
|
|
|
|
inspiratory phase
[s]
| baseline and
|
methacholine
|
|
......
0.0766
0.0809
MCh [mg/mL]:
......
0.0879
0.0955
......
0.0993
0.103
......
0.0958
0.107
......
0.0646
0.0931
|
Inbred
|
|
|
|
expiratory phase
[s]
| baseline and
|
methacholine
|
|
......
0.166
0.178
MCh [mg/mL]:
......
0.202
0.205
......
0.220
0.211
......
0.171
0.194
......
-0.107
-0.0159
|
Inbred
|
|
|
|
respiratory cycle
[s]
| baseline and
|
methacholine
|
|
......
0.243
0.259
MCh [mg/mL]:
......
0.290
0.301
......
0.319
0.315
......
0.268
0.301
......
-0.0504
0.0171
|
Inbred
|
|
|
|
duty cycle
[ratio]
| baseline and
|
methacholine
|
|
......
0.325
0.314
MCh [mg/mL]:
......
0.307
0.325
......
0.315
0.329
......
0.359
0.357
......
0.115
0.0762
|
Inbred
|
| |
|
respiratory — breathing pattern — efficiency
plethysmography
|
|
|
|
minute ventilation
[mL/min]
| baseline and
|
methacholine
|
|
......
76.9
70.1
MCh [mg/mL]:
......
46.2
53.1
......
41.4
55.6
......
56.4
53.9
......
0.139
0.0159
|
Inbred
|
|
|
|
breath frequency
[n/min]
| baseline and
|
methacholine
|
|
......
283
260
MCh [mg/mL]:
......
232
231
......
214
221
......
243
215
......
0.0361
-0.0433
|
Inbred
|
| |
|
respiratory — breathing pattern — enhanced pause
plethysmography
|
|
|
|
enhanced pause
| baseline and
|
methacholine
|
|
......
0.583
0.373
MCh [mg/mL]:
......
0.544
0.630
......
0.952
0.882
......
2.53
1.44
......
1.04
0.573
|
Inbred
|
| |
|
respiratory — lung compliance
ventilator
|
|
|
|
lung tissue dynamic elastance (H20 pressure)
[cm/mL]
| baseline and
|
methacholine
|
|
......
41.4
33.4
MCh [mg/mL]:
......
47.6
35.2
......
52.9
39.6
......
65.9
44.6
......
96.0
69.9
......
0.187
0.185
|
Inbred
|
| |
|
respiratory — lung volume
plethysmography
|
|
|
|
tidal volume
[mL]
| baseline and
|
methacholine
|
|
......
0.275
0.282
MCh [mg/mL]:
......
0.201
0.235
......
0.192
0.257
......
0.228
0.255
......
0.0870
0.0541
|
Inbred
|