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Phenotype data > MPD - Phenotype data: methacholine interventions >
methacholine
(bronchoconstrictor, respiratory tests)
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respiratory — airway resistance         ventilator  
Berndt1
resistance [cm/mL/s]     baseline and  methacholine      
• baseline    MCh challenge (mg/mL): • 1   • 3   • 10   • 30    • comparison  
36 strains   age 9-12wks
  Inbred
Berndt1
resistance (percent of baseline) [%]   methacholine      
MCh challenge (mg/mL): • 1   • 3   • 10   • 30    • comparison  
36 strains   age 9-12wks
  Inbred
Berndt2
airway resistance (H20 pressure) [cm/mL/s]     baseline and  methacholine      
  • saline    MCh [mg/mL]:   • 1    • 3    • 10    • 30    • comparison        
  • MCh response index 
29 strains   age 9-12wks
  Inbred
 
respiratory — breathing pattern — airflow rate         plethysmography  
Berndt2
inspiratory flow rate [mL/kg/s]     baseline and  methacholine      
  • saline    MCh [mg/mL]:   • 5    • 10    • 20    • comparison        
  • MCh response index 
29 strains   age 9-12wks
  Inbred
Berndt2
expiratory flow rate [mL/kg/s]     baseline and  methacholine      
  • saline    MCh [mg/mL]:   • 5    • 10    • 20    • comparison        
  • MCh response index 
29 strains   age 9-12wks
  Inbred
Berndt2
respiratory flow rate [mL/kg/s]     baseline and  methacholine      
  • saline    MCh [mg/mL]:   • 5    • 10    • 20    • comparison        
  • MCh response index 
29 strains   age 9-12wks
  Inbred
 
respiratory — breathing pattern — cycle         plethysmography  
Berndt2
inspiratory phase [s]     baseline and  methacholine      
  • saline    MCh [mg/mL]:   • 5    • 10    • 20    • comparison        
  • MCh response index 
29 strains   age 9-12wks
  Inbred
Berndt2
expiratory phase [s]     baseline and  methacholine      
  • saline    MCh [mg/mL]:   • 5    • 10    • 20    • comparison        
  • MCh response index 
29 strains   age 9-12wks
  Inbred
Berndt2
respiratory cycle [s]     baseline and  methacholine      
  • saline    MCh [mg/mL]:   • 5    • 10    • 20    • comparison        
  • MCh response index 
29 strains   age 9-12wks
  Inbred
Berndt2
duty cycle [ratio]     baseline and  methacholine      
  • saline    MCh [mg/mL]:   • 5    • 10    • 20    • comparison        
  • MCh response index 
29 strains   age 9-12wks
  Inbred
 
respiratory — breathing pattern — efficiency         plethysmography  
Berndt2
minute ventilation [mL/min]     baseline and  methacholine      
  • saline    MCh [mg/mL]:   • 5    • 10    • 20    • comparison        
  • MCh response index 
29 strains   age 9-12wks
  Inbred
Berndt2
breath frequency [n/min]     baseline and  methacholine      
  • saline    MCh [mg/mL]:   • 5    • 10    • 20    • comparison        
  • MCh response index 
29 strains   age 9-12wks
  Inbred
 
respiratory — breathing pattern — enhanced pause         plethysmography  
Berndt2
enhanced pause     baseline and  methacholine      
  • saline    MCh [mg/mL]:   • 5    • 10    • 20    • comparison        
  • MCh response index 
29 strains   age 9-12wks
  Inbred
 
respiratory — lung compliance         ventilator  
Berndt2
lung tissue dynamic elastance (H20 pressure) [cm/mL]     baseline and  methacholine      
  • saline    MCh [mg/mL]:   • 1    • 3    • 10    • 30    • comparison        
  • MCh response index 
29 strains   age 9-12wks
  Inbred
 
respiratory — lung volume         plethysmography  
Berndt2
tidal volume [mL]     baseline and  methacholine      
  • saline    MCh [mg/mL]:   • 5    • 10    • 20    • comparison        
  • MCh response index 
29 strains   age 9-12wks
  Inbred


 


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