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MPD - Phenotype data: methacholine
interventions
>
methacholine
(bronchoconstrictor, respiratory tests)
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respiratory — airway resistance
ventilator
Berndt1
resistance [cm/mL/s] baseline and
methacholine
• baseline
MCh challenge (mg/mL):
• 1
• 3
• 10
• 30
• comparison
36
strains
age
9-12wks
Inbred
Berndt1
resistance (percent of baseline) [%]
methacholine
MCh challenge (mg/mL):
• 1
• 3
• 10
• 30
• comparison
36
strains
age
9-12wks
Inbred
Berndt2
airway resistance (H
2
0 pressure) [cm/mL/s] baseline and
methacholine
• saline
MCh [mg/mL]:
• 1
• 3
• 10
• 30
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
respiratory — breathing pattern — airflow rate
plethysmography
Berndt2
inspiratory flow rate [mL/kg/s] baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
Berndt2
expiratory flow rate [mL/kg/s] baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
Berndt2
respiratory flow rate [mL/kg/s] baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
respiratory — breathing pattern — cycle
plethysmography
Berndt2
inspiratory phase [s] baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
Berndt2
expiratory phase [s] baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
Berndt2
respiratory cycle [s] baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
Berndt2
duty cycle [ratio] baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
respiratory — breathing pattern — efficiency
plethysmography
Berndt2
minute ventilation [mL/min] baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
Berndt2
breath frequency [n/min] baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
respiratory — breathing pattern — enhanced pause
plethysmography
Berndt2
enhanced pause baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
respiratory — lung compliance
ventilator
Berndt2
lung tissue dynamic elastance (H
2
0 pressure) [cm/mL] baseline and
methacholine
• saline
MCh [mg/mL]:
• 1
• 3
• 10
• 30
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
respiratory — lung volume
plethysmography
Berndt2
tidal volume [mL] baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
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