Home       About             Help       Phenotype data > BUB/BnJ strain > interventions > high-fat diet   Measurements: About these BUB/BnJ averages (♀ ♂) Exit BUB/BnJ mode blood — clinical chemistry — enzymes — ALT         metabolic panel   Paigen1 alanine aminotransferase (plasma ALT)   [IU/L] ......   high-fat diet   8wks 43 strains   age 15-19wks   Inbred   blood — clinical chemistry — glucose         metabolic panel   Naggert1 glucose (plasma GLU, 4h fast) [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 163   171         • after 17wks on diet  ...... 168   166         • Δchange  ...... 1.06   0.992           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — clinical chemistry — miscellaneous         metabolic panel   Paigen1 bile salts (plasma)   [µmol/L] ......   high-fat diet   8wks 43 strains   age 15-19wks   Inbred   blood — lipids — cholesterol — HDL         lipid profile   Paigen1 HDL cholesterol (plasma)   high-fat diet   8wks       • amount  ......       • % of total plasma cholesterol  ......       43 strains   age 15-19wks   Inbred Paigen2 HDL cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 44.1   63.4         • after 17wks on diet  ...... 46.8 ▼   63.4         • Δchange  ...... 1.14   1.02           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — lipids — cholesterol — LDL or non-HDL         lipid profile   Paigen1 plasma cholesterol not in the HDL fraction   [mg/dL] ......   high-fat diet   8wks 43 strains   age 15-19wks   Inbred Paigen2 non-HDL cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 15.1   21.4         • after 17wks on diet  ...... 178   94.4         • Δchange  ...... 24.1 ▲   3.80 (N=4)           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — lipids — cholesterol — total         lipid profile   Paigen1 total cholesterol (plasma)   [mg/dL] ......   high-fat diet   8wks 43 strains   age 15-19wks   Inbred Paigen2 total cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 59.2   84.6         • after 17wks on diet  ...... 225   158         • Δchange  ...... 3.95   1.90           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — lipids — triglycerides         lipid profile   Paigen2 triglycerides [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 132   169         • after 17wks on diet  ...... 79.2   66.4         • Δchange  ...... 0.620   0.399           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   body composition — fat — percent         DXA   Naggert1 percent of tissue mass that is fat, head excluded   [%] ...... 18.5   21.0     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body composition — fat — weight         DXA   Naggert1 weight of fat portion of tissue mass, head excluded   [g] ...... 4.94   6.64     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body composition — lean         DXA   Naggert1 weight of lean portion of tissue mass, head excluded   [g] ...... 21.6 ▲   24.9 ▲     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body composition — total         DXA   Naggert1 total tissue mass, head excluded   [g] ...... 26.6   31.6     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body weight         scales   Naggert1 body weight   [g] ...... 27.4   31.6     high-fat diet   8wks 43 strains   age 15-17wks   Inbred Paigen1 body weight [g]     baseline and  high-fat diet 8wks       • start  ......       • after 8wks on diet  ......       • Δchange  ......         • comparison   43 strains   age 7-11wks                 at baseline   Inbred   bone — mineral density and content — whole body without head         DXA   Naggert1 bone mineral density and content   high-fat diet   8wks       • BMD  ...... 0.0522   0.0542         • BMC  ...... 0.539 ▲   0.533         43 strains   age 15-17wks   Inbred   cardiovascular — atherosclerosis         histopathology   Paigen1 fatty streak aortic lesion size   [µm2] ...... 0 (N=3)     high-fat diet   8wks 43 strains   age 15-19wks   Inbred Paigen2 fatty streak aortic lesion size   [µm2] ...... 238   0     high-fat diet   17wks 43 strains   age 25-27wks   Inbred   endocrine — hormones — insulin         ELISA   Naggert1 insulin   [ng/mL] ...... 0.952   1.82     high-fat diet   18wks 43 strains   age 25-27wks   Inbred   endocrine — hormones — leptin         ELISA   Naggert1 leptin   [pg/mL] ...... 5509   6362     high-fat diet   18wks 43 strains   age 25-27wks   Inbred   gallbladder — pathology and gallstones         gravimetry   Paigen1 gallbladder volume   [µL] ......   high-fat diet   8wks 43 strains   age 15-19wks   Inbred   gallbladder — pathology and gallstones         histopathology   Paigen1 gallbladder pathology (0-4) [score]   high-fat diet   8wks       • mucin  ......       • arc  ......       • filaments  ......             liquid crystals:             • small  ......             • aggregated  ......             • fused  ......               • comparison         cholesterol monohydrate crystals:             • all  ......             43 strains   age 15-19wks   Inbred Paigen1 gallstones [n]   high-fat diet   8wks       • sandy  ......       • true  ......       • all  ......       • presence score [0/1]  ......         • comparison   43 strains   age 15-19wks   Inbred   liver — lipid homeostasis         lipid profile   Paigen1 hepatic cholesterol concentration [mg]   high-fat diet   8wks       • free  ......       • esterified  ......       • total  ......       • free to esterified ratio  ......       43 strains   age 15-19wks   Inbred   liver — pathology         histopathology   Paigen1 liver pathology (0-4) [score]   high-fat diet   8wks       • images  ......       • microvacuoles  ......       • macrovacuoles  ......       • inflammation  ......       43 strains   age 15-19wks   Inbred   liver — weight         scales   Paigen1 liver weight at sacrifice   [g] ......   high-fat diet   8wks 43 strains   age 15-19wks   Inbred

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