Home       About             Help       Phenotype data > NOD/ShiLtJ strain > interventions > high-fat diet   Measurements: About these NOD/ShiLtJ averages (♀ ♂) Exit NOD/ShiLtJ mode blood — clinical chemistry — enzymes — ALT         metabolic panel   Paigen1 alanine aminotransferase (plasma ALT)   [IU/L] ...... 17.3 ▼   298 ▲     high-fat diet   8wks 43 strains   age 15-19wks   Inbred   blood — clinical chemistry — glucose         metabolic panel   Naggert1 glucose (plasma GLU, 4h fast) [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 163   166         • after 17wks on diet  ...... 148   348 ▲▲         • Δchange  ...... 1.23 ▲   1.50 (N=4) ▲▲           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — clinical chemistry — miscellaneous         metabolic panel   Paigen1 bile salts (plasma)   [µmol/L] ...... 84.4   71.9     high-fat diet   8wks 43 strains   age 15-19wks   Inbred   blood — lipids — cholesterol — HDL         lipid profile   Paigen1 HDL cholesterol (plasma)   high-fat diet   8wks       • amount  ...... 98.8   133 ▲         • % of total plasma cholesterol  ...... 33.3   43.9         43 strains   age 15-19wks   Inbred Paigen2 HDL cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 54.6   80.8         • after 17wks on diet  ...... 143 ▲   146 ▲         • Δchange  ...... 2.55 ▲   1.73 (N=4)           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — lipids — cholesterol — LDL or non-HDL         lipid profile   Paigen1 plasma cholesterol not in the HDL fraction   [mg/dL] ...... 211   170     high-fat diet   8wks 43 strains   age 15-19wks   Inbred Paigen2 non-HDL cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 24.1   26.5         • after 17wks on diet  ...... 196   321 ▲         • Δchange  ...... 7.69   13.9 (N=2)           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — lipids — cholesterol — total         lipid profile   Paigen1 total cholesterol (plasma)   [mg/dL] ...... 311   303     high-fat diet   8wks 43 strains   age 15-19wks   Inbred Paigen2 total cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 78.6   106         • after 17wks on diet  ...... 411   467         • Δchange  ...... 5.24   4.43 (N=4)           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — lipids — triglycerides         lipid profile   Paigen2 triglycerides [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 93.1   96.2         • after 17wks on diet  ...... 48.5   159 ▲         • Δchange  ...... 0.620   2.44 (N=4) ▲▲           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   body composition — fat — percent         DXA   Naggert1 percent of tissue mass that is fat, head excluded   [%] ...... 21.4   19.5     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body composition — fat — weight         DXA   Naggert1 weight of fat portion of tissue mass, head excluded   [g] ...... 5.47   5.64     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body composition — lean         DXA   Naggert1 weight of lean portion of tissue mass, head excluded   [g] ...... 19.9   23.0     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body composition — total         DXA   Naggert1 total tissue mass, head excluded   [g] ...... 25.3   28.7     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body weight         scales   Naggert1 body weight   [g] ...... 26.1   29.0     high-fat diet   8wks 43 strains   age 15-17wks   Inbred Paigen1 body weight [g]     baseline and  high-fat diet 8wks       • start  ...... 21.3   25.8         • after 8wks on diet  ...... 26.1   30.1         • Δchange  ...... 1.24   1.17           • comparison   43 strains   age 7-11wks                 at baseline   Inbred   bone — mineral density and content — whole body without head         DXA   Naggert1 bone mineral density and content   high-fat diet   8wks       • BMD  ...... 0.0501   0.0480         • BMC  ...... 0.476   0.482         43 strains   age 15-17wks   Inbred   cardiovascular — atherosclerosis         histopathology   Paigen1 fatty streak aortic lesion size   [µm2] ...... 0   191     high-fat diet   8wks 43 strains   age 15-19wks   Inbred Paigen2 fatty streak aortic lesion size   [µm2] ...... 30.7   0     high-fat diet   17wks 43 strains   age 25-27wks   Inbred   endocrine — hormones — insulin         ELISA   Naggert1 insulin   [ng/mL] ...... 1.70 ▲   1.63     high-fat diet   18wks 43 strains   age 25-27wks   Inbred   endocrine — hormones — leptin         ELISA   Naggert1 leptin   [pg/mL] ...... 6541   8797     high-fat diet   18wks 43 strains   age 25-27wks   Inbred   gallbladder — pathology and gallstones         gravimetry   Paigen1 gallbladder volume   [µL] ...... 59.1 ▲▲   40.6 ▲     high-fat diet   8wks 43 strains   age 15-19wks   Inbred   gallbladder — pathology and gallstones         histopathology   Paigen1 gallbladder pathology (0-4) [score]   high-fat diet   8wks       • mucin  ...... 1.88   1.08         • arc  ...... 0   0         • filaments  ...... 0   0               liquid crystals:             • small  ...... 1.25   1.25               • aggregated  ...... 0.625   0.667               • fused  ...... 0.625   0.583                 • comparison         cholesterol monohydrate crystals:             • all  ...... 1.38 ▲   0.917               43 strains   age 15-19wks   Inbred Paigen1 gallstones [n]   high-fat diet   8wks       • sandy  ...... 3.75 ▲   5.50         • true  ...... 0   5.00 ▲         • all  ...... 3.75 ▲   10.5 ▲         • presence score [0/1]  ...... 0.375   0.333           • comparison   43 strains   age 15-19wks   Inbred   liver — lipid homeostasis         lipid profile   Paigen1 hepatic cholesterol concentration [mg]   high-fat diet   8wks       • free  ...... 6.09   5.39         • esterified  ...... 31.7   19.4         • total  ...... 46.3   25.7         • free to esterified ratio  ...... 0.228   0.298         43 strains   age 15-19wks   Inbred   liver — pathology         histopathology   Paigen1 liver pathology (0-4) [score]   high-fat diet   8wks       • images  ......       • microvacuoles  ...... 2.67 (N=3)   3.67 (N=3) ▲         • macrovacuoles  ...... 0.333 (N=3)   0 (N=3)         • inflammation  ...... 0.333 (N=3)   0.667 (N=3)         43 strains   age 15-19wks   Inbred   liver — weight         scales   Paigen1 liver weight at sacrifice   [g] ...... 2.36 ▲   2.66 ▲     high-fat diet   8wks 43 strains   age 15-19wks   Inbred

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