Home       About             Help       Phenotype data > BALB/cByJ strain > interventions > high-fat diet   Measurements: About these BALB/cByJ averages (♀ ♂) Exit BALB/cByJ mode blood — clinical chemistry — enzymes — ALT         metabolic panel   Rusyn5 serum alanine aminotransferase (ALT) [IU/L]   high-fat diet, ethanol       • high-fat only  ...... 15.6 (N=3)         • high-fat and ethanol  ...... 82.1 (N=3)           • comparison   14 strains   age 8-14wks   Inbred   blood — clinical chemistry — glucose         metabolic panel   Naggert1 glucose (plasma GLU, 4h fast) [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 183   167         • after 17wks on diet  ...... 137   136         • Δchange  ...... 0.750   0.869           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — clinical chemistry — proteins — misc         HPLC   Rusyn5 homocysteine concentration (plasma) [nmol/mL]   high-fat diet, ethanol       • high-fat only  ...... 4.70 (N=3)         • high-fat and ethanol  ...... 18.7 (N=3)           • comparison   14 strains   age 8-14wks   Inbred   blood — lipids — cholesterol — HDL         lipid profile   Paigen2 HDL cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 56.8   86.7         • after 17wks on diet  ...... 76.5   95.1         • Δchange  ...... 1.45   1.17           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — lipids — cholesterol — LDL or non-HDL         lipid profile   Paigen2 non-HDL cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 23.9   12.4 ▼         • after 17wks on diet  ...... 89.6   99.4         • Δchange  ...... 4.56   4.35           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — lipids — cholesterol — total         lipid profile   Paigen2 total cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 78.7   92.6         • after 17wks on diet  ...... 166   194         • Δchange  ...... 2.25   2.17           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — lipids — triglycerides         lipid profile   Paigen2 triglycerides [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 140   117         • after 17wks on diet  ...... 36.3   64.8         • Δchange  ...... 0.266   0.490           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — xenobiotics — alcohol concentration         spectrophotometry   Rusyn5 blood alcohol concentration (BAC) [mg/dL]   high-fat diet, ethanol       • high-fat only  ...... 31.5 (N=3)         • high-fat and ethanol  ...... 385 (N=3)           • comparison   14 strains   age 8-14wks   Inbred   body composition — fat — percent         DXA   Naggert1 percent of tissue mass that is fat, head excluded   [%] ...... 19.7     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body composition — fat — weight         DXA   Naggert1 weight of fat portion of tissue mass, head excluded   [g] ...... 5.56     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body composition — lean         DXA   Naggert1 weight of lean portion of tissue mass, head excluded   [g] ...... 22.5     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body composition — total         DXA   Naggert1 total tissue mass, head excluded   [g] ...... 28.1     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body weight         scales   Naggert1 body weight   [g] ...... 28.3     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   bone — mineral density and content — whole body without head         DXA   Naggert1 bone mineral density and content   high-fat diet   8wks       • BMD  ...... 0.0504         • BMC  ...... 0.485         43 strains   age 15-17wks   Inbred   cardiovascular — atherosclerosis         histopathology   Paigen2 fatty streak aortic lesion size   [µm2] ...... 409   288     high-fat diet   17wks 43 strains   age 25-27wks   Inbred   endocrine — hormones — insulin         ELISA   Naggert1 insulin   [ng/mL] ...... 1.48   1.51     high-fat diet   18wks 43 strains   age 25-27wks   Inbred   endocrine — hormones — leptin         ELISA   Naggert1 leptin   [pg/mL] ...... 5834   2132 ▼     high-fat diet   18wks 43 strains   age 25-27wks   Inbred   kidney — function — urinalysis         spectrophotometry   Rusyn5 urine alcohol concentration (UAC), daily average [mg/dL]   high-fat diet, ethanol       • high-fat only  ...... 17.4 (N=3)         • high-fat and ethanol  ...... 130 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 urine alcohol concentration (UAC), daily peak [mg/dL]   high-fat diet, ethanol       • high-fat only  ...... 51.0 (N=3)         • high-fat and ethanol  ...... 348 (N=3)           • comparison   14 strains   age 8-14wks   Inbred   liver — gene expression         RT-PCR   Rusyn5 Acox1 [%]   high-fat diet, ethanol   gene: Acox1         • high-fat only  ......       • high-fat and ethanol  ......         • comparison   6 strains   age 8-14wks   Inbred Rusyn5 Adipor2 [%]   high-fat diet, ethanol   gene: Adipor2         • high-fat only  ......       • high-fat and ethanol  ......         • comparison   6 strains   age 8-14wks   Inbred Rusyn5 Ahcy [%]   high-fat diet, ethanol   gene: Ahcy         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 89.5 (N=3) ▼           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Cbs [%]   high-fat diet, ethanol   gene: Cbs         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 51.4 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Cebpa [%]   high-fat diet, ethanol   gene: Cebpa         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 53.6 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Cth [%]   high-fat diet, ethanol   gene: Cth         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 106 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Ddit3 (Chop) [%]   high-fat diet, ethanol   gene: Ddit3         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 57.4 (N=3) ▼           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Gnmt [%]   high-fat diet, ethanol   gene: Gnmt         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 89.6 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Mat1a [%]   high-fat diet, ethanol   gene: Mat1a         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 123 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Mthfr [%]   high-fat diet, ethanol   gene: Mthfr         • high-fat only  ...... 100.0 (N=3)         • high-fat and ethanol  ...... 24.3 (N=3) ▼           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Mtr [%]   high-fat diet, ethanol   gene: Mtr         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 54.6 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Mttp [%]   high-fat diet, ethanol   gene: Mttp         • high-fat only  ......       • high-fat and ethanol  ......         • comparison   6 strains   age 8-14wks   Inbred Rusyn5 Srebf1 [%]   high-fat diet, ethanol   gene: Srebf1         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 53.6 (N=3)           • comparison   14 strains   age 8-14wks   Inbred   liver — lipid homeostasis         lipid profile   Rusyn5 hepatic triglycerides (TG) [mg/g]   high-fat diet, ethanol       • high-fat only  ......       • high-fat and ethanol  ......         • comparison   6 strains   age 8-14wks   Inbred   liver — pathology         histopathology   Rusyn5 liver steatosis (0-4) [score]   high-fat diet, ethanol       • high-fat only  ...... 0.167 (N=3)         • high-fat and ethanol  ...... 2.33 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver inflammation (0-2) [score]   high-fat diet, ethanol       • high-fat only  ...... 0.667 (N=3)         • high-fat and ethanol  ...... 0.667 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver necrosis (0-2) [score]   high-fat diet, ethanol       • high-fat only  ...... 0 (N=3)         • high-fat and ethanol  ...... 0.667 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 total liver histopathology (0-8) [score]   high-fat diet, ethanol       • high-fat only  ...... 0.833 (N=3)         • high-fat and ethanol  ...... 3.67 (N=3)           • comparison   14 strains   age 8-14wks   Inbred   liver — protein homeostasis         HPLC   Rusyn5 liver homocysteine [nmol/mg]   high-fat diet, ethanol       • high-fat only  ...... 0.247 (N=3) ▲         • high-fat and ethanol  ...... 0.327 (N=3) ▲           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver S-adenosylhomocysteine (SAH) [nmol/mg]   high-fat diet, ethanol       • high-fat only  ...... 0.303 (N=3) ▲         • high-fat and ethanol  ...... 0.350 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver methionine [nmol/mg]   high-fat diet, ethanol       • high-fat only  ...... 0.643 (N=3) ▼         • high-fat and ethanol  ...... 0.417 (N=3) ▼           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver S-adenosylmethionine (SAM) [nmol/mg]   high-fat diet, ethanol       • high-fat only  ...... 0.553 (N=3) ▼         • high-fat and ethanol  ...... 0.470 (N=3) ▼           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 ratio of liver SAM to SAH (SAM/SAH) [ratio]   high-fat diet, ethanol       • high-fat only  ...... 1.84 (N=3) ▼         • high-fat and ethanol  ...... 1.36 (N=3) ▼           • comparison   14 strains   age 8-14wks   Inbred   liver — protein homeostasis         Western blot   Rusyn5 BHMT [%]   high-fat diet, ethanol   gene: Bhmt         • high-fat only  ...... 100 (N=2)         • high-fat and ethanol  ...... 81.3 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 DDIT3 (CHOP) [%]   high-fat diet, ethanol   gene: Ddit3         • high-fat only  ...... 100 (N=2)         • high-fat and ethanol  ...... 102 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 HSPA5 (GRP78) [%]   high-fat diet, ethanol   gene: Hspa5         • high-fat only  ...... 100 (N=2)         • high-fat and ethanol  ...... 126 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 SREBF1 (NSREBP1) [%]   high-fat diet, ethanol   gene: Srebf1         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 92.0 (N=3)           • comparison   14 strains   age 8-14wks   Inbred   liver — protein homeostasis — glutathione         HPLC   Rusyn5 reduced liver glutathione (GSH) [nmol/mg]   high-fat diet, ethanol       • high-fat only  ...... 48.3 (N=3)         • high-fat and ethanol  ...... 26.7 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 oxidized liver glutathione (GSSG) [nmol/mg]   high-fat diet, ethanol       • high-fat only  ...... 2.34 (N=3) ▲         • high-fat and ethanol  ...... 2.97 (N=3) ▲▲           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 ratio of reduced to oxidized liver glutathione [ratio]   high-fat diet, ethanol       • high-fat only  ...... 20.8 (N=3) ▼         • high-fat and ethanol  ...... 9.43 (N=3) ▼           • comparison   14 strains   age 8-14wks   Inbred   liver — weight         scales   Rusyn5 liver weight as a percent of body weight [%]   high-fat diet, ethanol       • high-fat only  ...... 6.45 (N=3)         • high-fat and ethanol  ...... 7.91 (N=3)           • comparison   14 strains   age 8-14wks   Inbred

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