Home       About             Help       Phenotype data > CAST/EiJ strain > interventions > high-fat diet   Measurements: About these CAST/EiJ averages (♀ ♂) Exit CAST/EiJ mode blood — clinical chemistry — enzymes — ALT         metabolic panel   Paigen1 alanine aminotransferase (plasma ALT)   [IU/L] ...... 168   144     high-fat diet   8wks 43 strains   age 15-19wks   Inbred   blood — clinical chemistry — glucose         metabolic panel   Naggert1 glucose (plasma GLU, 4h fast) [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 196   217         • after 17wks on diet  ...... 147   160         • Δchange  ...... 0.756   0.795           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — clinical chemistry — miscellaneous         metabolic panel   Paigen1 bile salts (plasma)   [µmol/L] ...... 13.3 (N=1) ▼   75.8 (N=1)     high-fat diet   8wks 43 strains   age 15-19wks   Inbred   blood — lipids — cholesterol — HDL         lipid profile   Albers1 HDL cholesterol [mmol/L]     baseline and  high-fat diet 6wks       • baseline  ...... 0.800   0.980 ▼         • after 6wks on diet  ...... 0.930   2.40         • Δchange  ...... 1.16   2.45 ▲▲           • comparison   15 strains   age 6-8wks                 at baseline   Inbred Albers1 percentage of large HDL particles (10-13 nm) [%]     baseline and  high-fat diet 6wks       • baseline  ...... 27.1 ▼   26.3 ▼         • after 6wks on diet  ...... 34.0   27.6         • Δchange  ...... 1.25 ▲   1.05           • comparison   15 strains   age 6-8wks                 at baseline   Inbred Albers1 HDL peak size [nm]     baseline and  high-fat diet 6wks       • baseline  ...... 9.18   9.01 ▼         • after 6wks on diet  ...... 9.23   9.12         • Δchange  ...... 1.00   1.01           • comparison   15 strains   age 6-8wks                 at baseline   Inbred Paigen1 HDL cholesterol (plasma)   high-fat diet   8wks       • amount  ...... 21.7 ▼   59.8         • % of total plasma cholesterol  ...... 5.89 ▼▼   20.6 ▼         43 strains   age 15-19wks   Inbred Paigen2 HDL cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 37.7 ▼   44.6 ▼         • after 17wks on diet  ...... 41.0 ▼   67.9         • Δchange  ...... 1.12   1.55           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — lipids — cholesterol — LDL or non-HDL         lipid profile   Albers1 non-HDL cholesterol [mmol/L]     baseline and  high-fat diet 6wks       • baseline  ...... 0.690 ▲   0.470         • after 6wks on diet  ...... 19.3 ▲▲   5.82         • Δchange  ...... 27.9 ▲▲   12.4           • comparison   15 strains   age 6-8wks                 at baseline   Inbred Paigen1 plasma cholesterol not in the HDL fraction   [mg/dL] ...... 392 ▲▲   235     high-fat diet   8wks 43 strains   age 15-19wks   Inbred Paigen2 non-HDL cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 28.0   31.9         • after 17wks on diet  ...... 368   342 ▲▲         • Δchange  ...... 15.4   11.7           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — lipids — cholesterol — total         lipid profile   Albers1 total cholesterol [mmol/L]     baseline and  high-fat diet 6wks       • baseline  ...... 1.49   1.45 ▼         • after 6wks on diet  ...... 20.2 ▲▲   8.22         • Δchange  ...... 13.6 ▲▲   5.67 ▲           • comparison   15 strains   age 6-8wks                 at baseline   Inbred Paigen1 total cholesterol (plasma)   [mg/dL] ...... 429 ▲▲   295     high-fat diet   8wks 43 strains   age 15-19wks   Inbred Paigen2 total cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 65.7   76.5 ▼         • after 17wks on diet  ...... 409   410         • Δchange  ...... 6.24 ▲   5.41           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — lipids — phospholipid         lipid profile   Albers1 total phospholipid [mmol/L]     baseline and  high-fat diet 6wks       • baseline  ...... 1.10 ▼   1.27 ▼▼         • after 6wks on diet  ...... 3.23   3.32         • Δchange  ...... 2.94 ▲▲   2.61 ▲▲           • comparison   15 strains   age 6-8wks                 at baseline   Inbred Albers1 HDL phospholipid [mmol/L]     baseline and  high-fat diet 6wks       • baseline  ...... 0.890 ▼   1.02 ▼▼         • after 6wks on diet  ...... 0.620 ▼   2.10         • Δchange  ...... 0.700   2.06 ▲▲           • comparison   15 strains   age 6-8wks                 at baseline   Inbred Albers1 non-HDL phospholipid [mmol/L]     baseline and  high-fat diet 6wks       • baseline  ...... 0.220   0.250 ▼         • after 6wks on diet  ...... 2.61 ▲▲   1.22         • Δchange  ...... 11.9 ▲▲   4.88           • comparison   15 strains   age 6-8wks                 at baseline   Inbred   blood — lipids — phospholipid — transfer activity         radiolabeling   Albers1 phospholipid transfer protein activity [µmol/mL/h]     baseline and  high-fat diet 6wks       • baseline  ...... 14.0 ▼   15.2 ▼         • after 6wks on diet  ...... 35.7   41.1         • Δchange  ...... 2.55   2.70 ▲           • comparison   15 strains   age 6-8wks                 at baseline   Inbred   blood — lipids — triglycerides         lipid profile   Albers1 triglycerides [mmol/L]     baseline and  high-fat diet 6wks       • baseline  ...... 1.19   1.49         • after 6wks on diet  ...... 1.62 ▲▲   1.17         • Δchange  ...... 1.36 ▲▲   0.790           • comparison   15 strains   age 6-8wks                 at baseline   Inbred Paigen2 triglycerides [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 113   267 ▲▲         • after 17wks on diet  ...... 186 ▲   249 ▲▲         • Δchange  ...... 2.51 ▲   1.40 ▲           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   body composition — fat — percent         DXA   Naggert1 percent of tissue mass that is fat, head excluded   [%] ...... 17.8   17.2     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body composition — fat — weight         DXA   Naggert1 weight of fat portion of tissue mass, head excluded   [g] ...... 2.49 ▼   3.01 ▼     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body composition — lean         DXA   Naggert1 weight of lean portion of tissue mass, head excluded   [g] ...... 11.5 ▼   14.3 ▼     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body composition — total         DXA   Naggert1 total tissue mass, head excluded   [g] ...... 14.0 ▼   17.3 ▼     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body weight         scales   Naggert1 body weight   [g] ...... 14.9 ▼   17.5 ▼     high-fat diet   8wks 43 strains   age 15-17wks   Inbred Paigen1 body weight [g]     baseline and  high-fat diet 8wks       • start  ...... 12.3 ▼▼   13.9 ▼▼         • after 8wks on diet  ...... 13.9 ▼   16.1 ▼         • Δchange  ...... 1.13   1.16           • comparison   43 strains   age 7-11wks                 at baseline   Inbred   bone — mineral density and content — whole body without head         DXA   Naggert1 bone mineral density and content   high-fat diet   8wks       • BMD  ...... 0.0433 ▼   0.0436 ▼         • BMC  ...... 0.323 ▼   0.326 ▼         43 strains   age 15-17wks   Inbred   cardiovascular — atherosclerosis         histopathology   Paigen1 fatty streak aortic lesion size   [µm2] ...... 0   0     high-fat diet   8wks 43 strains   age 15-19wks   Inbred Paigen2 fatty streak aortic lesion size   [µm2] ...... 17.0   0     high-fat diet   17wks 43 strains   age 25-27wks   Inbred   endocrine — hormones — insulin         ELISA   Naggert1 insulin   [ng/mL] ...... 1.14   2.40     high-fat diet   18wks 43 strains   age 25-27wks   Inbred   endocrine — hormones — leptin         ELISA   Naggert1 leptin   [pg/mL] ...... 13507   10216     high-fat diet   18wks 43 strains   age 25-27wks   Inbred   gallbladder — pathology and gallstones         gravimetry   Paigen1 gallbladder volume   [µL] ...... 7.60 (N=4)   7.74     high-fat diet   8wks 43 strains   age 15-19wks   Inbred   gallbladder — pathology and gallstones         histopathology   Paigen1 gallbladder pathology (0-4) [score]   high-fat diet   8wks       • mucin  ...... 1.00   2.11         • arc  ...... 0   0         • filaments  ...... 0   0               liquid crystals:             • small  ...... 0.900   0.833               • aggregated  ...... 0.500   0.333 ▼               • fused  ...... 0.500   0.167                 • comparison         cholesterol monohydrate crystals:             • all  ...... 0   2.83 ▲               43 strains   age 15-19wks   Inbred Paigen1 gallstones [n]   high-fat diet   8wks       • sandy  ...... 0   12.1 ▲▲         • true  ...... 0   0         • all  ...... 0   12.1 ▲         • presence score [0/1]  ...... 0   0.667 ▲           • comparison   43 strains   age 15-19wks   Inbred   liver — lipid homeostasis         lipid profile   Paigen1 hepatic cholesterol concentration [mg]   high-fat diet   8wks       • free  ...... 4.90   7.09 ▲         • esterified  ...... 31.2   29.1         • total  ...... 36.2   39.2         • free to esterified ratio  ...... 0.158   0.290         43 strains   age 15-19wks   Inbred   liver — pathology         histopathology   Paigen1 liver pathology (0-4) [score]   high-fat diet   8wks       • images  ......       • microvacuoles  ...... 2.60   2.33 (N=3)         • macrovacuoles  ...... 0.400   0.333 (N=3)         • inflammation  ...... 0   0.667 (N=3)         43 strains   age 15-19wks   Inbred   liver — weight         scales   Paigen1 liver weight at sacrifice   [g] ...... 0.878 ▼   1.02 ▼     high-fat diet   8wks 43 strains   age 15-19wks   Inbred

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