Home       About             Help       Phenotype data > SJL/J strain > interventions > high-fat diet   Measurements: About these SJL/J averages (♀ ♂) Exit SJL/J mode blood — clinical chemistry — enzymes — ALT         metabolic panel   Paigen1 alanine aminotransferase (plasma ALT)   [IU/L] ...... 197   180     high-fat diet   8wks 43 strains   age 15-19wks   Inbred   blood — clinical chemistry — glucose         metabolic panel   Naggert1 glucose (plasma GLU, 4h fast) [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 192   219 ▲         • after 17wks on diet  ...... 159   150         • Δchange  ...... 0.838   0.700           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — clinical chemistry — miscellaneous         metabolic panel   Paigen1 bile salts (plasma)   [µmol/L] ...... 61.3   69.7     high-fat diet   8wks 43 strains   age 15-19wks   Inbred   blood — lipids — cholesterol — HDL         lipid profile   Albers1 HDL cholesterol [mmol/L]     baseline and  high-fat diet 6wks       • baseline  ...... 0.990   1.31         • after 6wks on diet  ...... 1.19         • Δchange  ...... 1.20           • comparison   15 strains   age 6-8wks                 at baseline   Inbred Albers1 percentage of large HDL particles (10-13 nm) [%]     baseline and  high-fat diet 6wks       • baseline  ...... 35.9         • after 6wks on diet  ...... 28.3         • Δchange  ...... 0.790           • comparison   15 strains   age 6-8wks                 at baseline   Inbred Albers1 HDL peak size [nm]     baseline and  high-fat diet 6wks       • baseline  ...... 9.15 ▼         • after 6wks on diet  ...... 9.16         • Δchange  ...... 1.00           • comparison   15 strains   age 6-8wks                 at baseline   Inbred Paigen1 HDL cholesterol (plasma)   high-fat diet   8wks       • amount  ...... 55.6   91.0 (N=1)         • % of total plasma cholesterol  ...... 31.1   50.6 (N=1)         43 strains   age 15-19wks   Inbred Paigen2 HDL cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 40.6   60.9         • after 17wks on diet  ...... 59.9   84.8         • Δchange  ...... 1.53   1.43           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — lipids — cholesterol — LDL or non-HDL         lipid profile   Albers1 non-HDL cholesterol [mmol/L]     baseline and  high-fat diet 6wks       • baseline  ...... 0.450   0.590         • after 6wks on diet  ...... 2.65         • Δchange  ...... 5.89 ▼           • comparison   15 strains   age 6-8wks                 at baseline   Inbred Paigen1 plasma cholesterol not in the HDL fraction   [mg/dL] ...... 127   89.0 (N=1)     high-fat diet   8wks 43 strains   age 15-19wks   Inbred Paigen2 non-HDL cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 38.9   34.6         • after 17wks on diet  ...... 75.3   141         • Δchange  ...... 2.27   5.60           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — lipids — cholesterol — total         lipid profile   Albers1 total cholesterol [mmol/L]     baseline and  high-fat diet 6wks       • baseline  ...... 1.44   1.90         • after 6wks on diet  ...... 3.84         • Δchange  ...... 2.67           • comparison   15 strains   age 6-8wks                 at baseline   Inbred Paigen1 total cholesterol (plasma)   [mg/dL] ...... 182   186     high-fat diet   8wks 43 strains   age 15-19wks   Inbred Paigen2 total cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 79.5   95.5         • after 17wks on diet  ...... 135   226         • Δchange  ...... 1.82   2.58           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   blood — lipids — phospholipid         lipid profile   Albers1 total phospholipid [mmol/L]     baseline and  high-fat diet 6wks       • baseline  ...... 1.73   2.53         • after 6wks on diet  ...... 2.04         • Δchange  ...... 1.18           • comparison   15 strains   age 6-8wks                 at baseline   Inbred Albers1 HDL phospholipid [mmol/L]     baseline and  high-fat diet 6wks       • baseline  ...... 1.43   1.99         • after 6wks on diet  ...... 1.37         • Δchange  ...... 0.960           • comparison   15 strains   age 6-8wks                 at baseline   Inbred Albers1 non-HDL phospholipid [mmol/L]     baseline and  high-fat diet 6wks       • baseline  ...... 0.300   0.540 ▲         • after 6wks on diet  ...... 0.670         • Δchange  ...... 2.23           • comparison   15 strains   age 6-8wks                 at baseline   Inbred   blood — lipids — phospholipid — transfer activity         radiolabeling   Albers1 phospholipid transfer protein activity [µmol/mL/h]     baseline and  high-fat diet 6wks       • baseline  ...... 22.4   26.3         • after 6wks on diet  ...... 43.6         • Δchange  ...... 1.95           • comparison   15 strains   age 6-8wks                 at baseline   Inbred   blood — lipids — triglycerides         lipid profile   Albers1 triglycerides [mmol/L]     baseline and  high-fat diet 6wks       • baseline  ...... 1.32   2.04 ▲         • after 6wks on diet  ...... 1.10         • Δchange  ...... 0.830           • comparison   15 strains   age 6-8wks                 at baseline   Inbred Paigen2 triglycerides [mg/dL]     baseline and  high-fat diet 17wks       • baseline  ...... 152   156         • after 17wks on diet  ...... 54.0   97.5         • Δchange  ...... 0.404   0.726           • comparison   43 strains   age 7-9wks                 at baseline   Inbred   body composition — fat — percent         DXA   Naggert1 percent of tissue mass that is fat, head excluded   [%] ...... 23.0   22.7     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body composition — fat — weight         DXA   Naggert1 weight of fat portion of tissue mass, head excluded   [g] ...... 4.87   5.96     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body composition — lean         DXA   Naggert1 weight of lean portion of tissue mass, head excluded   [g] ...... 16.1   20.0     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body composition — total         DXA   Naggert1 total tissue mass, head excluded   [g] ...... 21.0   26.0     high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body weight         scales   Naggert1 body weight   [g] ...... 21.7   26.6     high-fat diet   8wks 43 strains   age 15-17wks   Inbred Paigen1 body weight [g]     baseline and  high-fat diet 8wks       • start  ...... 19.3   22.5         • after 8wks on diet  ...... 22.2   27.5         • Δchange  ...... 1.16   1.21           • comparison   43 strains   age 7-11wks                 at baseline   Inbred   bone — mineral density and content — whole body without head         DXA   Naggert1 bone mineral density and content   high-fat diet   8wks       • BMD  ...... 0.0541   0.0548         • BMC  ...... 0.460   0.523         43 strains   age 15-17wks   Inbred   cardiovascular — atherosclerosis         histopathology   Paigen1 fatty streak aortic lesion size   [µm2] ...... 470   710     high-fat diet   8wks 43 strains   age 15-19wks   Inbred Paigen2 fatty streak aortic lesion size   [µm2] ...... 0   0     high-fat diet   17wks 43 strains   age 25-27wks   Inbred   endocrine — hormones — insulin         ELISA   Naggert1 insulin   [ng/mL] ...... 0.833   1.04     high-fat diet   18wks 43 strains   age 25-27wks   Inbred   endocrine — hormones — leptin         ELISA   Naggert1 leptin   [pg/mL] ...... 9040   5009     high-fat diet   18wks 43 strains   age 25-27wks   Inbred   gallbladder — pathology and gallstones         gravimetry   Paigen1 gallbladder volume   [µL] ...... 6.64   4.76     high-fat diet   8wks 43 strains   age 15-19wks   Inbred   gallbladder — pathology and gallstones         histopathology   Paigen1 gallbladder pathology (0-4) [score]   high-fat diet   8wks       • mucin  ...... 1.00   0.389 ▼         • arc  ...... 0   0         • filaments  ...... 0   0               liquid crystals:             • small  ...... 0.700 ▼   0.944               • aggregated  ...... 0.450   0.556               • fused  ...... 0.100 ▼   0.333                 • comparison         cholesterol monohydrate crystals:             • all  ...... 0.800   0.778               43 strains   age 15-19wks   Inbred Paigen1 gallstones [n]   high-fat diet   8wks       • sandy  ...... 0.400   0.444         • true  ...... 0.100   0.333         • all  ...... 0.500   0.778         • presence score [0/1]  ...... 0.300   0.111           • comparison   43 strains   age 15-19wks   Inbred   liver — lipid homeostasis         lipid profile   Paigen1 hepatic cholesterol concentration [mg]   high-fat diet   8wks       • free  ...... 4.54   4.01 ▼         • esterified  ...... 21.0   15.0 ▼         • total  ...... 24.6 ▼   19.4 ▼         • free to esterified ratio  ...... 0.220   0.297         43 strains   age 15-19wks   Inbred   liver — pathology         histopathology   Paigen1 liver pathology (0-4) [score]   high-fat diet   8wks       • images  ......       • microvacuoles  ...... 3.00 (N=3)   2.33 (N=3)         • macrovacuoles  ...... 0 (N=3)   0 (N=3)         • inflammation  ...... 0 (N=3)   0.667 (N=3)         43 strains   age 15-19wks   Inbred   liver — weight         scales   Paigen1 liver weight at sacrifice   [g] ...... 1.62   1.78     high-fat diet   8wks 43 strains   age 15-19wks   Inbred

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