Home       About             Help       Phenotype data > BKS.Cg-Dock7m +/+ Leprdb/J strain > interventions > high-fat diet   Measurements: About these BKS.Cg-Dock7m +/+ Leprdb/J averages (♀ ♂) Exit BKS.Cg-Dock7m +/+ Leprdb/J mode blood — clinical chemistry — enzymes — ALT         metabolic panel   Paigen3 alanine aminotransferase (plasma ALT)   [IU/L] ...... 407 ▲   252     high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants   blood — clinical chemistry — miscellaneous         metabolic panel   Paigen3 bile salts (plasma)   [µmol/L] ...... 104   110     high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants   blood — lipids — cholesterol — HDL         lipid profile   Paigen3 HDL cholesterol (plasma)   high-fat diet   8wks       • amount  ...... 94.9 ▲▲   108 ▲▲         • % of total plasma cholesterol  ...... 28.2   41.4 ▲         8 strains   age 15-19wks   obesity mutants   blood — lipids — cholesterol — LDL or non-HDL         lipid profile   Paigen3 plasma cholesterol not in the HDL fraction   [mg/dL] ...... 294 ▲   163     high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants   blood — lipids — cholesterol — total         lipid profile   Paigen3 total cholesterol (plasma)   [mg/dL] ...... 389 ▲   271     high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants   body weight         scales   Paigen3 body weight [g]     baseline and  high-fat diet 8wks       • start  ...... 42.6 ▲   37.4         • after 8wks on diet  ...... 39.9   44.9         • Δchange  ...... 0.945 ▼   1.28 ▲           • comparison   8 strains   age 7-11wks                 at baseline   obesity mutants   cardiovascular — atherosclerosis         histopathology   Paigen3 fatty streak aortic lesion size   [µm2] ...... 52.6 ▼   158     high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants   gallbladder — pathology and gallstones         gravimetry   Paigen3 gallbladder volume   [µL] ...... 15.0   14.1     high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants   gallbladder — pathology and gallstones         histopathology   Paigen3 gallbladder pathology (0-4) [score]   high-fat diet   8wks       • mucin  ...... 1.78   1.70         • arc  ...... 0   0         • filaments  ...... 0   0               liquid crystals:             • small  ...... 1.06   0.500 ▼               • aggregated  ...... 0.611   0.200 ▼               • fused  ...... 0.611   0.0500 ▼                 • comparison         cholesterol monohydrate crystals:             • all  ...... 0 ▼   0.0500               8 strains   age 15-19wks   obesity mutants Paigen3 gallstones [n]   high-fat diet   8wks       • sandy  ...... 0   0         • true  ...... 0   0         • all  ...... 0   0         • presence score [0/1]  ...... 0.0556   0           • comparison   8 strains   age 15-19wks   obesity mutants   liver — lipid homeostasis         lipid profile   Paigen3 hepatic cholesterol concentration [mg]   high-fat diet   8wks       • free  ...... 5.45   6.01         • esterified  ...... 33.9   27.5         • total  ...... 41.4   40.2         • free to esterified ratio  ...... 0.171   0.224         8 strains   age 15-19wks   obesity mutants   liver — pathology         histopathology   Paigen3 liver pathology (0-4) [score]   high-fat diet   8wks       • images  ......       • microvacuoles  ...... 4.00 (N=3) ▲   4.00 (N=3) ▲         • macrovacuoles  ...... 1.00 (N=3)   0 (N=3)         • inflammation  ...... 1.00 (N=3)   0.333 (N=3) ▼         8 strains   age 15-19wks   obesity mutants   liver — weight         scales   Paigen3 liver weight at sacrifice   [g] ...... 3.86   3.85     high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants

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