Home       About             Help       Phenotype data > KK/HlJ strain > interventions > high-fat diet and ethanol (liver study)   Measurements: About these KK/HlJ averages (♀ ♂) Exit KK/HlJ mode blood — clinical chemistry — enzymes — ALT         metabolic panel   Rusyn5 serum alanine aminotransferase (ALT) [IU/L]   high-fat diet, ethanol       • high-fat only  ...... 54.0 (N=3) ▲▲         • high-fat and ethanol  ...... 170 (N=3) ▲           • comparison   14 strains   age 8-14wks   Inbred   blood — clinical chemistry — proteins — misc         HPLC   Rusyn5 homocysteine concentration (plasma) [nmol/mL]   high-fat diet, ethanol       • high-fat only  ...... 3.58 (N=3) ▼         • high-fat and ethanol  ...... 8.48 (N=3)           • comparison   14 strains   age 8-14wks   Inbred   blood — xenobiotics — alcohol concentration         spectrophotometry   Rusyn5 blood alcohol concentration (BAC) [mg/dL]   high-fat diet, ethanol       • high-fat only  ...... 30.2 (N=3)         • high-fat and ethanol  ...... 226 (N=3)           • comparison   14 strains   age 8-14wks   Inbred   kidney — function — urinalysis         spectrophotometry   Rusyn5 urine alcohol concentration (UAC), daily average [mg/dL]   high-fat diet, ethanol       • high-fat only  ...... 27.6 (N=3) ▲         • high-fat and ethanol  ...... 139 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 urine alcohol concentration (UAC), daily peak [mg/dL]   high-fat diet, ethanol       • high-fat only  ...... 168 (N=3) ▲▲         • high-fat and ethanol  ...... 532 (N=3)           • comparison   14 strains   age 8-14wks   Inbred   liver — gene expression         RT-PCR   Rusyn5 Acox1 [%]   high-fat diet, ethanol   gene: Acox1         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 70.9 (N=3)           • comparison   6 strains   age 8-14wks   Inbred Rusyn5 Adipor2 [%]   high-fat diet, ethanol   gene: Adipor2         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 59.7 (N=3)           • comparison   6 strains   age 8-14wks   Inbred Rusyn5 Ahcy [%]   high-fat diet, ethanol   gene: Ahcy         • high-fat only  ...... 100.0 (N=3)         • high-fat and ethanol  ...... 136 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Cbs [%]   high-fat diet, ethanol   gene: Cbs         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 58.1 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Cebpa [%]   high-fat diet, ethanol   gene: Cebpa         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 168 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Cth [%]   high-fat diet, ethanol   gene: Cth         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 102 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Ddit3 (Chop) [%]   high-fat diet, ethanol   gene: Ddit3         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 208 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Gnmt [%]   high-fat diet, ethanol   gene: Gnmt         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 136 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Mat1a [%]   high-fat diet, ethanol   gene: Mat1a         • high-fat only  ...... 100.0 (N=3)         • high-fat and ethanol  ...... 119 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Mthfr [%]   high-fat diet, ethanol   gene: Mthfr         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 66.8 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Mtr [%]   high-fat diet, ethanol   gene: Mtr         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 37.1 (N=3) ▼           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Mttp [%]   high-fat diet, ethanol   gene: Mttp         • high-fat only  ...... 100.0 (N=3)         • high-fat and ethanol  ...... 93.9 (N=3) ▼           • comparison   6 strains   age 8-14wks   Inbred Rusyn5 Srebf1 [%]   high-fat diet, ethanol   gene: Srebf1         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 37.9 (N=3) ▼           • comparison   14 strains   age 8-14wks   Inbred   liver — lipid homeostasis         lipid profile   Rusyn5 hepatic triglycerides (TG) [mg/g]   high-fat diet, ethanol       • high-fat only  ...... 16.3 (N=3)         • high-fat and ethanol  ...... 72.5 (N=3)           • comparison   6 strains   age 8-14wks   Inbred   liver — pathology         histopathology   Rusyn5 liver steatosis (0-4) [score]   high-fat diet, ethanol       • high-fat only  ...... 0.667 (N=3) ▲▲         • high-fat and ethanol  ...... 3.50 (N=3) ▲           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver inflammation (0-2) [score]   high-fat diet, ethanol       • high-fat only  ...... 2.00 (N=3) ▲         • high-fat and ethanol  ...... 1.00 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver necrosis (0-2) [score]   high-fat diet, ethanol       • high-fat only  ...... 1.00 (N=3) ▲▲         • high-fat and ethanol  ...... 0 (N=3) ▼           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 total liver histopathology (0-8) [score]   high-fat diet, ethanol       • high-fat only  ...... 3.67 (N=3) ▲▲         • high-fat and ethanol  ...... 4.50 (N=3)           • comparison   14 strains   age 8-14wks   Inbred   liver — protein homeostasis         HPLC   Rusyn5 liver homocysteine [nmol/mg]   high-fat diet, ethanol       • high-fat only  ...... 0.240 (N=3)         • high-fat and ethanol  ...... 0.287 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver S-adenosylhomocysteine (SAH) [nmol/mg]   high-fat diet, ethanol       • high-fat only  ...... 0.283 (N=3)         • high-fat and ethanol  ...... 0.373 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver methionine [nmol/mg]   high-fat diet, ethanol       • high-fat only  ...... 0.907 (N=3)         • high-fat and ethanol  ...... 0.520 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver S-adenosylmethionine (SAM) [nmol/mg]   high-fat diet, ethanol       • high-fat only  ...... 0.680 (N=3)         • high-fat and ethanol  ...... 0.567 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 ratio of liver SAM to SAH (SAM/SAH) [ratio]   high-fat diet, ethanol       • high-fat only  ...... 2.38 (N=3)         • high-fat and ethanol  ...... 1.53 (N=3)           • comparison   14 strains   age 8-14wks   Inbred   liver — protein homeostasis         Western blot   Rusyn5 BHMT [%]   high-fat diet, ethanol   gene: Bhmt         • high-fat only  ...... 100 (N=2)         • high-fat and ethanol  ...... 106 (N=2)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 DDIT3 (CHOP) [%]   high-fat diet, ethanol   gene: Ddit3         • high-fat only  ...... 100 (N=2)         • high-fat and ethanol  ...... 137 (N=2)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 HSPA5 (GRP78) [%]   high-fat diet, ethanol   gene: Hspa5         • high-fat only  ...... 100 (N=2)         • high-fat and ethanol  ...... 115 (N=2)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 SREBF1 (NSREBP1) [%]   high-fat diet, ethanol   gene: Srebf1         • high-fat only  ...... 100 (N=3)         • high-fat and ethanol  ...... 100 (N=3)           • comparison   14 strains   age 8-14wks   Inbred   liver — protein homeostasis — glutathione         HPLC   Rusyn5 reduced liver glutathione (GSH) [nmol/mg]   high-fat diet, ethanol       • high-fat only  ...... 48.8 (N=3)         • high-fat and ethanol  ...... 30.7 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 oxidized liver glutathione (GSSG) [nmol/mg]   high-fat diet, ethanol       • high-fat only  ...... 1.66 (N=3)         • high-fat and ethanol  ...... 1.96 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Rusyn5 ratio of reduced to oxidized liver glutathione [ratio]   high-fat diet, ethanol       • high-fat only  ...... 30.9 (N=3)         • high-fat and ethanol  ...... 14.6 (N=3)           • comparison   14 strains   age 8-14wks   Inbred   liver — weight         scales   Rusyn5 liver weight as a percent of body weight [%]   high-fat diet, ethanol       • high-fat only  ...... 6.16 (N=3)         • high-fat and ethanol  ...... 7.37 (N=3)           • comparison   14 strains   age 8-14wks   Inbred

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