blood — clinical chemistry — electrolytes — calcium         metabolic panel   Shockley1 calcium (Ca) [mg/dL]     control and  high-fat diet 4wks       • control diet   • high-fat diet   • difference    • comparison   10 strains   age 10-13wks   Inbred   blood — clinical chemistry — enzymes — ALT         metabolic panel   Paigen1 alanine aminotransferase (plasma ALT)   [IU/L]   high-fat diet   8wks 43 strains   age 15-19wks   Inbred Rusyn5 serum alanine aminotransferase (ALT) [IU/L]   high-fat diet, ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Paigen3 alanine aminotransferase (plasma ALT)   [IU/L]   high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants   blood — clinical chemistry — enzymes — misc         metabolic panel   Shockley1 glutamate dehydrogenase (GLDH) [IU/L]     control and  high-fat diet 4wks       • control diet   • high-fat diet   • difference    • comparison   10 strains   age 10-13wks   Inbred   blood — clinical chemistry — glucose         metabolic panel   Naggert1 glucose (plasma GLU, 4h fast) [mg/dL]     baseline and  high-fat diet 17wks       • baseline   • after 17wks on diet   • Δchange    • comparison   43 strains   age 7-9wks                 at baseline   Inbred Shockley1 glucose (GLU) [mg/dL]     control and  high-fat diet 4wks       • control diet   • high-fat diet   • difference    • comparison   10 strains   age 10-13wks   Inbred   blood — clinical chemistry — glucose — glucose tolerance test         glucose tolerance   Cheverud1 glucose levels, area under curve, glucose tolerance test (serum GLU, 10% glucose i.p., 4h fast) [AUC]     control and  high-fat diet         age 10wks:   • control diet    • high-fat diet    • comparison           age 20wks:   • control diet    • high-fat diet    • comparison           compare ages:   control diet    high-fat diet  19 strains   ages shown   LGXSM   blood — clinical chemistry — miscellaneous         metabolic panel   Paigen1 bile salts (plasma)   [µmol/L]   high-fat diet   8wks 43 strains   age 15-19wks   Inbred Paigen3 bile salts (plasma)   [µmol/L]   high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants   blood — clinical chemistry — proteins — misc         HPLC   Rusyn5 homocysteine concentration (plasma) [nmol/mL]   high-fat diet, ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred   blood — clinical chemistry — urea nitrogen         metabolic panel   Shockley1 blood urea nitrogen (BUN) [mg/dL]     control and  high-fat diet 4wks       • control diet   • high-fat diet   • difference    • comparison   10 strains   age 10-13wks   Inbred   blood — lipids — cholesterol — HDL         lipid profile   Albers1 HDL cholesterol [mmol/L]     baseline and  high-fat diet 6wks       • baseline   • after 6wks on diet   • Δchange    • comparison   15 strains   age 6-8wks                 at baseline   Inbred Albers1 percentage of large HDL particles (10-13 nm) [%]     baseline and  high-fat diet 6wks       • baseline   • after 6wks on diet   • Δchange    • comparison   15 strains   age 6-8wks                 at baseline   Inbred Albers1 HDL peak size [nm]     baseline and  high-fat diet 6wks       • baseline   • after 6wks on diet   • Δchange    • comparison   15 strains   age 6-8wks                 at baseline   Inbred Paigen1 HDL cholesterol (plasma)   high-fat diet   8wks       • amount  • % of total plasma cholesterol  43 strains   age 15-19wks   Inbred Paigen2 HDL cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline   • after 17wks on diet   • Δchange    • comparison   43 strains   age 7-9wks                 at baseline   Inbred Shockley1 HDL cholesterol (HDL) [mg/dL]     control and  high-fat diet 4wks       • control diet   • high-fat diet   • difference    • comparison   10 strains   age 10-13wks   Inbred Paigen3 HDL cholesterol (plasma)   high-fat diet   8wks       • amount  • % of total plasma cholesterol  8 strains   age 15-19wks   obesity mutants   blood — lipids — cholesterol — LDL or non-HDL         lipid profile   Albers1 non-HDL cholesterol [mmol/L]     baseline and  high-fat diet 6wks       • baseline   • after 6wks on diet   • Δchange    • comparison   15 strains   age 6-8wks                 at baseline   Inbred Paigen1 plasma cholesterol not in the HDL fraction   [mg/dL]   high-fat diet   8wks 43 strains   age 15-19wks   Inbred Paigen2 non-HDL cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline   • after 17wks on diet   • Δchange    • comparison   43 strains   age 7-9wks                 at baseline   Inbred Paigen3 plasma cholesterol not in the HDL fraction   [mg/dL]   high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants   blood — lipids — cholesterol — total         lipid profile   Albers1 total cholesterol [mmol/L]     baseline and  high-fat diet 6wks       • baseline   • after 6wks on diet   • Δchange    • comparison   15 strains   age 6-8wks                 at baseline   Inbred Paigen1 total cholesterol (plasma)   [mg/dL]   high-fat diet   8wks 43 strains   age 15-19wks   Inbred Paigen2 total cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline   • after 17wks on diet   • Δchange    • comparison   43 strains   age 7-9wks                 at baseline   Inbred Shockley1 total cholesterol (CHOL) [mg/dL]     control and  high-fat diet 4wks       • control diet   • high-fat diet   • difference    • comparison   10 strains   age 10-13wks   Inbred Cheverud1 total cholesterol (serum CHOL) [mg/dL]     control and  high-fat diet 17wks       • control diet  • high-fat diet    • comparison   19 strains   age 20-30wks   LGXSM Paigen3 total cholesterol (plasma)   [mg/dL]   high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants   blood — lipids — fatty acids         lipid profile   Shockley1 nonesterified fatty acid (NEFA) [mEq/L]     control and  high-fat diet 4wks       • control diet   • high-fat diet   • difference    • comparison   10 strains   age 10-13wks   Inbred Cheverud1 free fatty acid (serum FFA) [mg/dL]     control and  high-fat diet 17wks       • control diet  • high-fat diet    • comparison   19 strains   age 20-30wks   LGXSM   blood — lipids — phospholipid         lipid profile   Albers1 total phospholipid [mmol/L]     baseline and  high-fat diet 6wks       • baseline   • after 6wks on diet   • Δchange    • comparison   15 strains   age 6-8wks                 at baseline   Inbred Albers1 HDL phospholipid [mmol/L]     baseline and  high-fat diet 6wks       • baseline   • after 6wks on diet   • Δchange    • comparison   15 strains   age 6-8wks                 at baseline   Inbred Albers1 non-HDL phospholipid [mmol/L]     baseline and  high-fat diet 6wks       • baseline   • after 6wks on diet   • Δchange    • comparison   15 strains   age 6-8wks                 at baseline   Inbred   blood — lipids — phospholipid — transfer activity         radiolabeling   Albers1 phospholipid transfer protein activity [µmol/mL/h]     baseline and  high-fat diet 6wks       • baseline   • after 6wks on diet   • Δchange    • comparison   15 strains   age 6-8wks                 at baseline   Inbred   blood — lipids — triglycerides         lipid profile   Albers1 triglycerides [mmol/L]     baseline and  high-fat diet 6wks       • baseline   • after 6wks on diet   • Δchange    • comparison   15 strains   age 6-8wks                 at baseline   Inbred Paigen2 triglycerides [mg/dL]     baseline and  high-fat diet 17wks       • baseline   • after 17wks on diet   • Δchange    • comparison   43 strains   age 7-9wks                 at baseline   Inbred Shockley1 triglycerides (TG) [mg/dL]     control and  high-fat diet 4wks       • control diet   • high-fat diet   • difference    • comparison   10 strains   age 10-13wks   Inbred Cheverud1 triglycerides (serum TG) [mg/dL]     control and  high-fat diet 17wks       • control diet  • high-fat diet    • comparison   19 strains   age 20-30wks   LGXSM   blood — xenobiotics — alcohol concentration         spectrophotometry   Rusyn5 blood alcohol concentration (BAC) [mg/dL]   high-fat diet, ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred   body composition — fat — percent         DXA   Naggert1 percent of tissue mass that is fat, head excluded   [%]   high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body composition — fat — weight         DXA   Naggert1 weight of fat portion of tissue mass, head excluded   [g]   high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body composition — lean         DXA   Naggert1 weight of lean portion of tissue mass, head excluded   [g]   high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body composition — total         DXA   Naggert1 total tissue mass, head excluded   [g]   high-fat diet   8wks 43 strains   age 15-17wks   Inbred   body fat pads         scales   Cheverud1 gonadal fat pad weight [g]     control and  high-fat diet 17wks         weight [g]:   • control diet    • high-fat diet    • comparison           as percent of body weight [%]:   • control diet    • high-fat diet    • comparison   19 strains   age 20-30wks   LGXSM Cheverud1 perirenal fat pad weight [g]     control and  high-fat diet 17wks         weight [g]:   • control diet    • high-fat diet    • comparison           as percent of body weight [%]:   • control diet    • high-fat diet    • comparison   19 strains   age 20-30wks   LGXSM Cheverud1 mesenteric fat pad weight [g]     control and  high-fat diet 17wks         weight [g]:   • control diet    • high-fat diet    • comparison           as percent of body weight [%]:   • control diet    • high-fat diet    • comparison   19 strains   age 20-30wks   LGXSM Cheverud1 inguinal fat pad weight [g]     control and  high-fat diet 17wks         weight [g]:   • control diet    • high-fat diet    • comparison           as percent of body weight [%]:   • control diet    • high-fat diet    • comparison   19 strains   age 20-30wks   LGXSM Cheverud1 total fat pad weight [g]     control and  high-fat diet 17wks         weight [g]:   • control diet    • high-fat diet    • comparison           as percent of body weight [%]:   • control diet    • high-fat diet    • comparison   19 strains   age 20-30wks   LGXSM   body weight         scales   Naggert1 body weight   [g]   high-fat diet   8wks 43 strains   age 15-17wks   Inbred Paigen1 body weight [g]     baseline and  high-fat diet 8wks       • start   • after 8wks on diet   • Δchange    • comparison   43 strains   age 7-11wks                 at baseline   Inbred Shockley1 body weight [g]     control and  high-fat diet 4wks       • control diet   • high-fat diet   • difference    • comparison   10 strains   age 10-13wks   Inbred Nadeau1 body weight [g]     baseline and  high-fat diet 12wks       • baseline   • after 12wks on diet   • Δchange    • comparison   24 strains   age 5wks                 at baseline   B6.A consomic Paigen3 body weight [g]     baseline and  high-fat diet 8wks       • start   • after 8wks on diet   • Δchange    • comparison   8 strains   age 7-11wks                 at baseline   obesity mutants   body weight growth curve         scales   Cheverud1 body weight / growth curve, high-fat diet [g]   high-fat diet         age (wks): • 4  • 5  • 6  • 7  • 9  • 11  • 15  • 19  • 23    • growth curve comparison   19 strains   ages shown   LGXSM   growth rate (weight)         scales   Cheverud1 growth rate [g/wk]     control and  high-fat diet         post-weaning (4-10wks):   • control diet    • high-fat diet    • comparison           adult (11-20wks):   • control diet    • high-fat diet    • comparison   19 strains   ages shown   LGXSM   bone — mineral density and content — whole body without head         DXA   Naggert1 bone mineral density and content   high-fat diet   8wks       • BMD   • BMC  43 strains   age 15-17wks   Inbred   cardiovascular — atherosclerosis         histopathology   Paigen1 fatty streak aortic lesion size   [µm2]   high-fat diet   8wks 43 strains   age 15-19wks   Inbred Paigen2 fatty streak aortic lesion size   [µm2]   high-fat diet   17wks 43 strains   age 25-27wks   Inbred Paigen3 fatty streak aortic lesion size   [µm2]   high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants   cardiovascular — heart weight         scales   Cheverud1 heart weight as percent of body weight [%]     control and  high-fat diet 17wks       • control diet  • high-fat diet    • comparison   19 strains   age 20-30wks   LGXSM   endocrine — hormones — insulin         ELISA   Naggert1 insulin   [ng/mL]   high-fat diet   18wks 43 strains   age 25-27wks   Inbred   endocrine — hormones — insulin         radioimmunoassay   Cheverud1 insulin (serum) [ng/mL]     control and  high-fat diet 17wks       • control diet  • high-fat diet    • comparison   19 strains   age 20-30wks   LGXSM   endocrine — hormones — leptin         ELISA   Naggert1 leptin   [pg/mL]   high-fat diet   18wks 43 strains   age 25-27wks   Inbred   endocrine — hormones — leptin         radioimmunoassay   Cheverud1 leptin (serum) [pg/mL]     control and  high-fat diet 17wks       • control diet  • high-fat diet    • comparison   19 strains   age 20-30wks   LGXSM   endocrine — hormones — thyroxine         metabolic panel   Shockley1 thyroxine (T4) [µg/dL]     control and  high-fat diet 4wks       • control diet   • high-fat diet   • difference    • comparison   10 strains   age 10-13wks   Inbred   gallbladder — pathology and gallstones         gravimetry   Paigen1 gallbladder volume   [µL]   high-fat diet   8wks 43 strains   age 15-19wks   Inbred Paigen3 gallbladder volume   [µL]   high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants   gallbladder — pathology and gallstones         histopathology   Paigen1 gallbladder pathology (0-4) [score]   high-fat diet   8wks         • mucin    • arc    • filaments          liquid crystals:   • small    • aggregated    • fused    • comparison           cholesterol monohydrate crystals:   • all  43 strains   age 15-19wks   Inbred Paigen1 gallstones [n]   high-fat diet   8wks       • sandy  • true  • all  • presence score [0/1]    • comparison   43 strains   age 15-19wks   Inbred Paigen3 gallbladder pathology (0-4) [score]   high-fat diet   8wks         • mucin    • arc    • filaments          liquid crystals:   • small    • aggregated    • fused    • comparison           cholesterol monohydrate crystals:   • all  8 strains   age 15-19wks   obesity mutants Paigen3 gallstones [n]   high-fat diet   8wks       • sandy  • true  • all  • presence score [0/1]    • comparison   8 strains   age 15-19wks   obesity mutants   kidney — function — urinalysis         spectrophotometry   Rusyn5 urine alcohol concentration (UAC), daily average [mg/dL]   high-fat diet, ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 urine alcohol concentration (UAC), daily peak [mg/dL]   high-fat diet, ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred   kidney — morphology — weight         scales   Cheverud1 kidney weight (both) as percent of body weight [%]     control and  high-fat diet 17wks       • control diet  • high-fat diet    • comparison   19 strains   age 20-30wks   LGXSM   liver — gene expression         RT-PCR   Rusyn5 Acox1 [%]   high-fat diet, ethanol   gene: Acox1         • high-fat only  • high-fat and ethanol    • comparison   6 strains   age 8-14wks   Inbred Rusyn5 Adipor2 [%]   high-fat diet, ethanol   gene: Adipor2         • high-fat only  • high-fat and ethanol    • comparison   6 strains   age 8-14wks   Inbred Rusyn5 Ahcy [%]   high-fat diet, ethanol   gene: Ahcy         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Cbs [%]   high-fat diet, ethanol   gene: Cbs         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Cebpa [%]   high-fat diet, ethanol   gene: Cebpa         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Cth [%]   high-fat diet, ethanol   gene: Cth         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Ddit3 (Chop) [%]   high-fat diet, ethanol   gene: Ddit3         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Gnmt [%]   high-fat diet, ethanol   gene: Gnmt         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Mat1a [%]   high-fat diet, ethanol   gene: Mat1a         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Mthfr [%]   high-fat diet, ethanol   gene: Mthfr         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Mtr [%]   high-fat diet, ethanol   gene: Mtr         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Mttp [%]   high-fat diet, ethanol   gene: Mttp         • high-fat only  • high-fat and ethanol    • comparison   6 strains   age 8-14wks   Inbred Rusyn5 Srebf1 [%]   high-fat diet, ethanol   gene: Srebf1         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred   liver — lipid homeostasis         lipid profile   Paigen1 hepatic cholesterol concentration [mg]   high-fat diet   8wks       • free  • esterified  • total   • free to esterified ratio  43 strains   age 15-19wks   Inbred Rusyn5 hepatic triglycerides (TG) [mg/g]   high-fat diet, ethanol       • high-fat only  • high-fat and ethanol    • comparison   6 strains   age 8-14wks   Inbred Paigen3 hepatic cholesterol concentration [mg]   high-fat diet   8wks       • free  • esterified  • total   • free to esterified ratio  8 strains   age 15-19wks   obesity mutants   liver — pathology         histopathology   Paigen1 liver pathology (0-4) [score]   high-fat diet   8wks       • images  • microvacuoles  • macrovacuoles  • inflammation  43 strains   age 15-19wks   Inbred Rusyn5 liver steatosis (0-4) [score]   high-fat diet, ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver inflammation (0-2) [score]   high-fat diet, ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver necrosis (0-2) [score]   high-fat diet, ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 total liver histopathology (0-8) [score]   high-fat diet, ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Paigen3 liver pathology (0-4) [score]   high-fat diet   8wks       • images  • microvacuoles  • macrovacuoles  • inflammation  8 strains   age 15-19wks   obesity mutants   liver — protein homeostasis         HPLC   Rusyn5 liver homocysteine [nmol/mg]   high-fat diet, ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver S-adenosylhomocysteine (SAH) [nmol/mg]   high-fat diet, ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver methionine [nmol/mg]   high-fat diet, ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver S-adenosylmethionine (SAM) [nmol/mg]   high-fat diet, ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 ratio of liver SAM to SAH (SAM/SAH) [ratio]   high-fat diet, ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred   liver — protein homeostasis         Western blot   Rusyn5 BHMT [%]   high-fat diet, ethanol   gene: Bhmt         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 DDIT3 (CHOP) [%]   high-fat diet, ethanol   gene: Ddit3         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 HSPA5 (GRP78) [%]   high-fat diet, ethanol   gene: Hspa5         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 SREBF1 (NSREBP1) [%]   high-fat diet, ethanol   gene: Srebf1         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred   liver — protein homeostasis — glutathione         HPLC   Rusyn5 reduced liver glutathione (GSH) [nmol/mg]   high-fat diet, ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 oxidized liver glutathione (GSSG) [nmol/mg]   high-fat diet, ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 ratio of reduced to oxidized liver glutathione [ratio]   high-fat diet, ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred   liver — weight         scales   Paigen1 liver weight at sacrifice   [g]   high-fat diet   8wks 43 strains   age 15-19wks   Inbred Rusyn5 liver weight as a percent of body weight [%]   high-fat diet, ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Cheverud1 liver weight as percent of body weight [%]     control and  high-fat diet 17wks       • control diet  • high-fat diet    • comparison   19 strains   age 20-30wks   LGXSM Paigen3 liver weight at sacrifice   [g]   high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants   local experiment parameter   Cheverud1 body weight at necropsy [g]     control and  high-fat diet 17wks       • control diet  • high-fat diet    • comparison   19 strains   age 20-30wks   LGXSM   spleen — weight         scales   Cheverud1 spleen weight as percent of body weight [%]     control and  high-fat diet 17wks       • control diet  • high-fat diet    • comparison   19 strains   age 20-30wks   LGXSM

279 measurements listed.