|
behavior — balance and coordination
inclined screen test
|
|
|
|
extrapyramidal side effects (EPS)
[s]
| baseline and
|
haloperidol
|
|
day:
......
2.40
......
2.80
......
3.60
......
4.20
......
8.25
(N=4)
......
4.25
(N=4)
|
Inbred
|
| |
|
behavior — exploratory
open field test
|
|
|
|
center occupancy
[%]
| baseline and
|
haloperidol
|
|
day:
......
2.03
......
1.07
......
1.09
(N=4)
......
0.958
(N=4)
|
Inbred
|
| |
|
behavior — involuntary movement
observation
|
|
|
|
tongue protrusion
[n]
| baseline and
|
haloperidol
|
|
day:
......
13.4
......
2.40
......
5.25
(N=4)
......
10.5
(N=4)
|
Inbred
|
|
|
|
overt chewing movement
[n]
| baseline and
|
haloperidol
|
|
day:
......
4.20
......
12.0
......
45.2
(N=4)
......
3.25
(N=4)
|
Inbred
|
|
|
|
subtle chewing movement
[n]
| baseline and
|
haloperidol
|
|
day:
......
16.8
......
46.4
......
68.2
(N=4)
......
55.5
(N=4)
|
Inbred
|
|
|
|
jaw tremor
[s]
| baseline and
|
haloperidol
|
|
day:
......
0
......
1.40
......
0
(N=4)
......
1.50
(N=4)
|
Inbred
|
| |
|
behavior — involuntary movement
open field test
|
|
|
|
repetitive behavior (stereotypy)
[n]
| baseline and
|
haloperidol
|
|
day:
......
4107
......
2573
......
2576
(N=4)
......
3704
(N=4)
|
Inbred
|
| |
|
behavior — locomotor activity
open field test
|
|
|
|
distance traveled
[cm]
| baseline and
|
haloperidol
|
|
day:
......
5805
......
3208
......
3283
(N=4)
......
3980
(N=4)
|
Inbred
|
|
|
|
vertical activity
[n]
| baseline and
|
haloperidol
|
|
day:
......
157
......
74.2
......
64.2
(N=4)
......
54.8
(N=4)
|
Inbred
|
| |
|
blood — xenobiotics — drug and metabolite concentration
mass spectrometry
|
|
|
|
plasma haloperidol concentration
[nM]
|
haloperidol
|
|
day:
......
11.5
......
9.55
(N=4)
......
3.77
(N=4)
......
2.65
(N=4)
|
Inbred
|
| |
|
body weight
scales
|
|
|
|
body weight
[g]
| baseline and
|
haloperidol
|
|
......
26.4
......
34.0
(N=4)
|
Inbred
|