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SM/J strain > interventions
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MPD - Phenotype data: haloperidol
haloperidol
(antipsychotic)
See also:
Wikipedia
Measurements:
About these
SM/J
averages
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SM/J
mode
behavior — balance and coordination
inclined screen test
Crowley1
extrapyramidal side effects (EPS) [s]
baseline and
haloperidol
day:
• 0
......
1.25
▼
• 3
......
4.12
• 7
......
4.62
• 30
......
4.62
• 60
......
4.88
• 120
......
2.75
• time comparison
27
strains
age
9-28wks
Inbred
behavior — exploratory
open field test
Crowley1
center occupancy [%]
baseline and
haloperidol
day:
• 0
......
14.2
▲
• 30
......
11.3
▲
• 60
......
13.6
▲
• 120
......
14.2
▲
• time comparison
27
strains
age
9-28wks
Inbred
behavior — involuntary movement
observation
Crowley1
tongue protrusion [n]
baseline and
haloperidol
day:
• 0
......
32.6
▲
• 30
......
38.5
▲
• 60
......
45.8
▲▲
• 120
......
18.2
• time comparison
27
strains
age
9-28wks
Inbred
Crowley1
overt chewing movement [n]
baseline and
haloperidol
day:
• 0
......
29.1
• 30
......
56.8
• 60
......
75.8
• 120
......
77.5
▲
• time comparison
27
strains
age
9-28wks
Inbred
Crowley1
subtle chewing movement [n]
baseline and
haloperidol
day:
• 0
......
35.4
• 30
......
158
• 60
......
143
▲
• 120
......
135
▲
• time comparison
27
strains
age
9-28wks
Inbred
Crowley1
jaw tremor [s]
baseline and
haloperidol
day:
• 0
......
21.8
▲
• 30
......
21.8
• 60
......
14.4
• 120
......
18.4
• time comparison
27
strains
age
9-28wks
Inbred
behavior — involuntary movement
open field test
Crowley1
repetitive behavior (stereotypy) [n]
baseline and
haloperidol
day:
• 0
......
7409
▲
• 30
......
3880
• 60
......
5743
▲
• 120
......
7190
▲
• time comparison
27
strains
age
9-28wks
Inbred
behavior — locomotor activity
open field test
Crowley1
distance traveled [cm]
baseline and
haloperidol
day:
• 0
......
11338
▲
• 30
......
5025
• 60
......
6291
▲
• 120
......
9148
▲
• time comparison
27
strains
age
9-28wks
Inbred
Crowley1
vertical activity [n]
baseline and
haloperidol
day:
• 0
......
1149
▲
• 30
......
479
• 60
......
526
▲
• 120
......
712
• time comparison
27
strains
age
9-28wks
Inbred
blood — xenobiotics — drug and metabolite concentration
mass spectrometry
Crowley1
plasma haloperidol concentration [nM]
haloperidol
day:
• 30
......
24.6
• 60
......
20.1
• 90
......
10.7
• 120
......
5.05
• time comparison
27
strains
age
9-28wks
Inbred
body weight
scales
Crowley1
body weight [g]
baseline and
haloperidol
• starting
......
26.8
• ending
......
30.0
• time comparison
27
strains
age
9-28wks
Inbred
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