|
behavior — balance and coordination
inclined screen test
|
|
|
extrapyramidal side effects (EPS)
[s]
baseline and
haloperidol
day:
......
2.00
......
37.2
......
45.2
......
43.2
......
27.0
......
30.2
(N=4)
|
Inbred
|
| |
|
behavior — exploratory
open field test
|
|
|
center occupancy
[%]
baseline and
haloperidol
day:
......
4.01
......
9.90
......
6.99
......
10.9
(N=4)
|
Inbred
|
| |
|
behavior — involuntary movement
observation
|
|
|
tongue protrusion
[n]
baseline and
haloperidol
day:
......
0.200
......
2.40
......
17.4
......
1.75
(N=4)
|
Inbred
|
|
|
overt chewing movement
[n]
baseline and
haloperidol
day:
......
12.2
......
48.8
......
116
......
85.8
(N=4)
|
Inbred
|
|
|
subtle chewing movement
[n]
baseline and
haloperidol
day:
......
58.8
......
123
......
57.8
......
64.8
(N=4)
|
Inbred
|
|
|
jaw tremor
[s]
baseline and
haloperidol
day:
......
1.00
......
9.20
......
0.800
......
7.00
(N=4)
|
Inbred
|
| |
|
behavior — involuntary movement
open field test
|
|
|
repetitive behavior (stereotypy)
[n]
baseline and
haloperidol
day:
......
3884
......
3616
......
4104
......
3987
(N=4)
|
Inbred
|
| |
|
behavior — locomotor activity
open field test
|
|
|
distance traveled
[cm]
baseline and
haloperidol
day:
......
2981
......
3254
......
3861
......
3475
(N=4)
|
Inbred
|
|
|
vertical activity
[n]
baseline and
haloperidol
day:
......
335
......
161
......
276
......
202
(N=4)
|
Inbred
|
| |
|
blood — xenobiotics — drug and metabolite concentration
mass spectrometry
|
|
|
plasma haloperidol concentration
[nM]
haloperidol
day:
......
26.1
......
22.7
......
12.4
(N=4)
......
7.45
(N=4)
|
Inbred
|
| |
|
body weight
scales
|
|
|
body weight
[g]
baseline and
haloperidol
......
23.7
......
30.1
(N=4)
|
Inbred
|