Home       About             Help       Phenotype data > FVB/NJ strain > interventions > ethanol (alcohol EtOH)   See also:   Wikipedia Measurements: About these FVB/NJ averages (♀ ♂) Exit FVB/NJ mode behavior — balance and coordination         balance beam   Crabbe1 missteps crossing balance beam [n]     control and  ethanol       12.7mm beam:             • control  ...... 0.667 (N=3)   0.667 (N=3)               i.p. doses g/kg:             • 1.0  ...... 1.95   2.66               • 1.2  ...... 2.24   3.47               • 1.4  ...... 1.05 ▼   4.11                 • comparison   8 strains   age 8-16wks   Inbred Crabbe1 missteps crossing balance beam [n]     control and  ethanol       15.8mm beam:             • control  ...... 0 (N=3) ▼   0.333 (N=3)               i.p. doses g/kg:             • 1.0  ...... 1.33   1.64               • 1.2  ...... 0.903   0.903 ▼               • 1.4  ...... 0.499 ▼   3.12                 • comparison   8 strains   age 8-16wks   Inbred Crabbe1 missteps crossing balance beam [n]     control and  ethanol       19.0mm beam:             • control  ...... 0 (N=3) ▼   1.00 (N=3)               i.p. doses g/kg:             • 1.0  ...... 0.800   1.20               • 1.2  ...... 0.800   2.40               • 1.4  ...... 0.700   1.70                 • comparison   8 strains   age 8-16wks   Inbred   behavior — balance and coordination         dowel balance test   Crabbe4 latency to fall [s]   ethanol   2g/kg i.p.       T0:             • 9.5mm  ...... 68.5 (N=2)   53.0 (N=2)               • 15.8mm  ...... 70.0 (N=2) ▼   129 (N=3)                 • comparison         T30:             • 9.5mm  ...... 11.0 (N=2)   8.50 (N=2)               • 15.8mm  ...... 180 (N=2)   4.67 (N=3)                 • comparison   8 strains   age 12-16wks   Inbred   behavior — balance and coordination         grid test   Crabbe1 grid habituation, distance traveled [cm]     control and  ethanol       • control  ...... 836 ▲   962 ▲         i.p. doses g/kg:             • 1.5  ...... 2161 (N=4) ▲   1342 (N=4) ▲               • 2.0  ...... 1976 (N=4) ▲   1991 (N=4) ▲               • 2.5  ...... 1228 (N=4)   679 (N=4)                 • comparison   8 strains   age 8-16wks   Inbred Crabbe1 grid habituation, missteps per cm [n/cm]     control and  ethanol       • control  ...... 0.0131 ▲   0.0187 ▲▲         i.p. doses g/kg:             • 1.5  ...... 0.0405 (N=4)   0.0622 (N=4) ▼               • 2.0  ...... 0.0935 (N=4) ▼   0.107 (N=4)               • 2.5  ...... 0.344 (N=4)   0.458 (N=4) ▲                 • comparison   8 strains   age 8-16wks   Inbred   behavior — balance and coordination         parallel rod floor test   Crabbe5 motor incoordination (errors/distance traveled) 1.6mm rod, 6mm space [n/cm]     control and  ethanol       • day1 control  ...... 3.07 ▲         • day2 control  ...... 9.65 ▲▲         • day3 ethanol  ...... 21.6           • comparison   8 strains   age 7-14wks   Inbred   behavior — balance and coordination         rotarod   Crabbe3 fixed speed 3 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg:             • 1  ...... 151 (N=4)   157 (N=4)               • 2  ...... 96.5 (N=4)   77.1 (N=4)               • 3  ...... 83.9 (N=3)   109 (N=4) ▲                 • comparison   9 strains   age 9-17wks   Inbred Crabbe3 fixed speed 6 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg:             • 1  ...... 122 (N=4)   129 (N=4)               • 2  ...... 73.1 (N=4) ▼   54.8 (N=4)               • 3  ...... 120 (N=4) ▲▲   53.2 (N=4)                 • comparison   9 strains   age 9-17wks   Inbred Crabbe3 fixed speed 10 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg:             • 1  ...... 85.4 (N=3)   140 (N=3) ▲               • 2  ...... 109 (N=3)   63.2 (N=3)               • 3  ...... 64.0 (N=4)   41.4 (N=2)                 • comparison   9 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test day 1 20 rpm/min (ARR1) [s]     baseline and  ethanol various i.p.       • baseline  ...... 20.5   19.2         • ethanol  ...... 31.0   34.0         • Δchange (ethanol effect)  ...... 11.2   17.1 ▲         8 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test day 2 30 rpm/min (ARR1) [s]     baseline and  ethanol various i.p.       • baseline  ...... 19.3   14.5 ▼         • ethanol  ...... 29.7   27.4         • Δchange (ethanol effect)  ...... 13.6 ▲   14.0         8 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test 20 rpm/min (ARR2) [s]     baseline and  ethanol 2g/kg i.p.       • baseline  ...... 33.1 ▼   30.5 ▼         • ethanol  ...... 50.4   35.8         • Δchange (ethanol effect)  ...... 17.3 ▲   5.32 ▲         • Δchange (saline control)  ...... 4.45   8.68         21 strains   age 9-17wks   Inbred   behavior — balance and coordination         vertical wire mesh   Crabbe4 latency to fall from a vertical wire mesh grid 30 min post-injection, screen test   [s] ...... 151   194     ethanol   2g/kg i.p. 8 strains   age 9-10wks   Inbred   behavior — balance and coordination — observer-rated ataxia         observation   Metten1 hindlimb splay, 2.75 g/kg injection [score]   ethanol   2.75g/kg i.p.       • 10min after injection  ...... 0.500 (N=4) ▼   0.250 (N=4) ▼         • 30min after  ...... 0.250 (N=4) ▼   0 (N=3)           • comparison   9 strains   age 8-11wks   Inbred Metten1 hindlimb splay, 3.0 g/kg injection [score]   ethanol   3.0g/kg i.p.       • 10min after injection  ...... 1.25 (N=4) ▼   1.00 (N=4) ▼         • 30min after  ...... 0.500 (N=2) ▼   0 (N=3) ▼           • comparison   9 strains   age 8-11wks   Inbred Metten1 erratic gait, 2.75 g/kg injection [score]   ethanol   2.75g/kg i.p.       • 10min after injection  ...... 1.50 (N=4) ▲   1.00 (N=4) ▲         • 30min after  ...... 0.250 (N=4)   0.333 (N=3)           • comparison   9 strains   age 8-11wks   Inbred Metten1 erratic gait, 3.0 g/kg injection [score]   ethanol   3.0g/kg i.p.       • 10min after injection  ...... 2.00 (N=4) ▲   0.750 (N=4)         • 30min after  ...... 1.00 (N=2) ▲   1.00 (N=3) ▲           • comparison   9 strains   age 8-11wks   Inbred Metten1 compare dose groups, hindlimb splay   ethanol         10min after        30min after        9 strains   age 8-11wks   Inbred Metten1 compare dose groups, eratic gait   ethanol         10min after        30min after        9 strains   age 8-11wks   Inbred   behavior — involuntary movement — handling-induced convulsion         observation   Metten2 peak handling-induced convulsion score [score]     control and  ethanol aerosolized       • control  ...... 1.95         • ethanol  ...... 4.06         • ethanol normalized to controls  ...... 2.11         15 strains   age 8-15wks   Inbred Metten2 latency to first score used to calculate peak ethanol   [h] ...... 2.44     ethanol   aerosolized 15 strains   age 8-15wks   Inbred Metten2 withdrawal severity during 0-25h (area under curve of HIC scores) [AUC]   ethanol   aerosolized       • ethanol  ...... 57.8         • ethanol normalized to controls  ...... 53.1         15 strains   age 8-15wks   Inbred   behavior — locomotor activity         open field test   Metten1 line crossings, 2.75 g/kg injection [n]     control and  ethanol 2.75g/kg i.p.       • pre-injection  ...... 15.2 (N=4)   7.00 (N=4)         • 10min after injection  ...... 22.0 (N=4) ▲   22.0 (N=4) ▲         • 30min after  ...... 28.5 (N=4) ▲▲   15.7 (N=3) ▲           • comparison   9 strains   age 8-11wks   Inbred Metten1 line crossings, 3.0 g/kg injection [n]     control and  ethanol 3.0g/kg i.p.       • pre-injection  ...... 11.5 (N=4)   12.2 (N=4)         • 10min after injection  ...... 15.2 (N=4) ▲   13.2 (N=4) ▲         • 30min after  ...... 22.0 (N=2) ▲   18.3 (N=3)           • comparison   9 strains   age 8-11wks   Inbred Metten1 line crossings, compare dose groups     control and  ethanol       pre-injection        10min after injection        30min after        9 strains   age 8-11wks   Inbred   behavior — locomotor activity         parallel rod floor test   Crabbe5 distance traveled, 1.6mm rod, 6mm space [cm]     control and  ethanol       • day1 control  ...... 1080 ▲         • day2 control  ...... 789         • day3 ethanol  ...... 1931 ▲           • comparison   8 strains   age 8-10wks   Inbred   blood — xenobiotics — alcohol concentration         gas chromatography   Crabbe4 blood ethanol concentration (BEC), 35 min post-injection, dowel (15.8 mm) test   [mg/mL] ...... 1.39 (N=2)   1.82 (N=3)     ethanol   2g/kg i.p. 8 strains   age 12-16wks   Inbred Crabbe4 blood ethanol levels following grip strength test at various times after treatment [mg/mL]   ethanol   2g/kg i.p.       time after ethanol:             • 30min  ...... 1.60   1.67               • 60min  ...... 1.73   1.59               • 105min  ...... 1.11   0.937 ▼               • 150min  ...... 0.642   0.388 ▼                 • time comparison   21 strains   age 7-12wks   Inbred   muscle — skeletal — function         grip strength   Crabbe4 grip strength test: peak force applied [g]     baseline and  ethanol 2g/kg i.p.       • baseline  ...... 122   138         • 30min after ethanol  ...... 85.2   83.3         • change (ethanol effect)  ...... 36.5   55.0         • % change (ethanol effect)  ...... 28.9   39.1         21 strains   age 7-12wks   Inbred

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