Home       About             Help       Phenotype data > C57BL/6J strain > interventions > ethanol (alcohol EtOH)   See also:   Wikipedia Measurements: About these C57BL/6J averages (♀ ♂) Exit C57BL/6J mode behavior — balance and coordination         balance beam   Crabbe1 missteps crossing balance beam [n]     control and  ethanol       12.7mm beam:             • control  ...... 1.00 (N=3)   1.00 (N=3)               i.p. doses g/kg:             • 1.0  ...... 2.17   2.50               • 1.2  ...... 1.33 ▼   2.14               • 1.4  ...... 4.17   4.00                 • comparison   8 strains   age 8-16wks   Inbred Crabbe1 missteps crossing balance beam [n]     control and  ethanol       15.8mm beam:             • control  ...... 0.667 (N=3)   1.00 (N=3)               i.p. doses g/kg:             • 1.0  ...... 1.50   0.837 ▼               • 1.2  ...... 0.808   2.50               • 1.4  ...... 4.00   2.74                 • comparison   8 strains   age 8-16wks   Inbred Crabbe1 missteps crossing balance beam [n]     control and  ethanol       19.0mm beam:             • control  ...... 0 (N=3) ▼   0.667 (N=3)               i.p. doses g/kg:             • 1.0  ...... 0.752 (N=4)   1.75 (N=4)               • 1.2  ...... 1.33 (N=4)   1.39               • 1.4  ...... 1.75 (N=4)   3.87 ▲                 • comparison   8 strains   age 8-16wks   Inbred   behavior — balance and coordination         dowel balance test   Crabbe4 latency to fall [s]   ethanol   2g/kg i.p.       T0:             • 9.5mm  ...... 90.8 (N=4)   115 (N=4)               • 15.8mm  ...... 146 (N=4) ▲   95.2 (N=4)                 • comparison         T30:             • 9.5mm  ...... 20.0 (N=4)   9.00 (N=4)               • 15.8mm  ...... 179 (N=4)   65.5 (N=4)                 • comparison   8 strains   age 12-16wks   Inbred   behavior — balance and coordination         grid test   Crabbe1 grid habituation, distance traveled [cm]     control and  ethanol       • control  ...... 516   604         i.p. doses g/kg:             • 1.5  ...... 865 (N=4)   611 (N=4)               • 2.0  ...... 485 (N=3) ▼   500 (N=3)               • 2.5  ...... 522 (N=1)   626 (N=1)                 • comparison   8 strains   age 8-16wks   Inbred Crabbe1 grid habituation, missteps per cm [n/cm]     control and  ethanol       • control  ...... 0.00517   0.00525         i.p. doses g/kg:             • 1.5  ...... 0.0730 (N=3)   0.0900 (N=4)               • 2.0  ...... 0.186 (N=2)   0.167 (N=3)               • 2.5  ...... 0.255 (N=1)   0.0650 (N=1) ▼                 • comparison   8 strains   age 8-16wks   Inbred   behavior — balance and coordination         parallel rod floor test   Crabbe5 motor incoordination (errors/distance traveled) 1.6mm rod, 6mm space [n/cm]     control and  ethanol       • day1 control  ...... 1.55   1.44         • day2 control  ...... 2.66   1.93         • day3 ethanol  ...... 41.4 ▲   19.9           • comparison   8 strains   age 7-14wks   Inbred   behavior — balance and coordination         rotarod   Crabbe3 fixed speed 3 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg:             • 1  ...... 150 (N=4)   159 (N=4)               • 2  ...... 107 (N=4)   107 (N=4) ▲               • 3  ...... 98.9 (N=4)   108 (N=4) ▲                 • comparison   9 strains   age 9-17wks   Inbred Crabbe3 fixed speed 6 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg:             • 1  ...... 103 (N=4)   113 (N=4)               • 2  ...... 62.6 (N=4) ▼   55.1 (N=4)               • 3  ...... 74.2 (N=4)   45.3 (N=4)                 • comparison   9 strains   age 9-17wks   Inbred Crabbe3 fixed speed 10 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg:             • 1  ...... 98.6 (N=3)   76.5 (N=4)               • 2  ...... 85.5 (N=4)   53.9 (N=3)               • 3  ...... 44.6 (N=3)   43.2 (N=3)                 • comparison   9 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test day 1 20 rpm/min (ARR1) [s]     baseline and  ethanol various i.p.       • baseline  ...... 50.2 ▲   35.1         • ethanol  ...... 51.4 ▲   38.1 (N=4)         • Δchange (ethanol effect)  ...... 4.30   -2.65 (N=4)         8 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test day 2 30 rpm/min (ARR1) [s]     baseline and  ethanol various i.p.       • baseline  ...... 38.4   28.7         • ethanol  ...... 35.9   42.7 ▲         • Δchange (ethanol effect)  ...... -1.14   14.3         8 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test 20 rpm/min (ARR2) [s]     baseline and  ethanol 2g/kg i.p.       • baseline  ...... 51.9   41.4         • ethanol  ...... 38.2   43.8         • Δchange (ethanol effect)  ...... -13.6   2.35 ▲         • Δchange (saline control)  ...... 12.7   1.85         21 strains   age 9-17wks   Inbred   behavior — balance and coordination         vertical wire mesh   Crabbe4 latency to fall from a vertical wire mesh grid 30 min post-injection, screen test   [s] ...... 98.4 ▼   64.8 ▼     ethanol   2g/kg i.p. 8 strains   age 9-10wks   Inbred   behavior — balance and coordination — observer-rated ataxia         observation   Metten1 hindlimb splay, 2.75 g/kg injection [score]   ethanol   2.75g/kg i.p.       • 10min after injection  ...... 2.17   2.29         • 30min after  ...... 0.667   1.57           • comparison   9 strains   age 8-11wks   Inbred Metten1 hindlimb splay, 3.0 g/kg injection [score]   ethanol   3.0g/kg i.p.       • 10min after injection  ...... 2.86   3.17         • 30min after  ...... 1.86   3.17 ▲           • comparison   9 strains   age 8-11wks   Inbred Metten1 erratic gait, 2.75 g/kg injection [score]   ethanol   2.75g/kg i.p.       • 10min after injection  ...... 0.833   0.714         • 30min after  ...... 0.833   0.857           • comparison   9 strains   age 8-11wks   Inbred Metten1 erratic gait, 3.0 g/kg injection [score]   ethanol   3.0g/kg i.p.       • 10min after injection  ...... 0.429   0.667         • 30min after  ...... 0.714 ▲   0.500           • comparison   9 strains   age 8-11wks   Inbred Metten1 compare dose groups, hindlimb splay   ethanol         10min after        30min after        9 strains   age 8-11wks   Inbred Metten1 compare dose groups, eratic gait   ethanol         10min after        30min after        9 strains   age 8-11wks   Inbred   behavior — involuntary movement — handling-induced convulsion         observation   Metten2 peak handling-induced convulsion score [score]     control and  ethanol aerosolized       • control  ...... 0.444         • ethanol  ...... 2.63 ▼▼         • ethanol normalized to controls  ...... 2.19         15 strains   age 8-15wks   Inbred Metten2 latency to first score used to calculate peak ethanol   [h] ...... 4.11     ethanol   aerosolized 15 strains   age 8-15wks   Inbred Metten2 withdrawal severity during 0-25h (area under curve of HIC scores) [AUC]   ethanol   aerosolized       • ethanol  ...... 21.3 ▼         • ethanol normalized to controls  ...... 25.4 ▼         15 strains   age 8-15wks   Inbred   behavior — locomotor activity         open field test   Metten1 line crossings, 2.75 g/kg injection [n]     control and  ethanol 2.75g/kg i.p.       • pre-injection  ...... 14.2   10.6         • 10min after injection  ...... 8.83   3.71         • 30min after  ...... 14.5   2.71 ▼           • comparison   9 strains   age 8-11wks   Inbred Metten1 line crossings, 3.0 g/kg injection [n]     control and  ethanol 3.0g/kg i.p.       • pre-injection  ...... 16.1   17.0         • 10min after injection  ...... 9.43   8.33         • 30min after  ...... 8.43   3.83 ▼           • comparison   9 strains   age 8-11wks   Inbred Metten1 line crossings, compare dose groups     control and  ethanol       pre-injection        10min after injection        30min after        9 strains   age 8-11wks   Inbred   behavior — locomotor activity         parallel rod floor test   Crabbe5 distance traveled, 1.6mm rod, 6mm space [cm]     control and  ethanol       • day1 control  ...... 578   850         • day2 control  ...... 703   889         • day3 ethanol  ...... 892   963           • comparison   8 strains   age 8-10wks   Inbred   blood — xenobiotics — alcohol concentration         gas chromatography   Crabbe4 blood ethanol concentration (BEC), 35 min post-injection, dowel (15.8 mm) test   [mg/mL] ...... 1.53 (N=4)   2.19 (N=4) ▲     ethanol   2g/kg i.p. 8 strains   age 12-16wks   Inbred Crabbe4 blood ethanol levels following grip strength test at various times after treatment [mg/mL]   ethanol   2g/kg i.p.       time after ethanol:             • 30min  ...... 1.94 ▲   1.92 ▲               • 60min  ...... 1.76 ▲   1.88 ▲               • 105min  ...... 1.39 ▲   1.39               • 150min  ...... 0.895 ▲   0.887                 • time comparison   21 strains   age 7-12wks   Inbred   muscle — skeletal — function         grip strength   Crabbe4 grip strength test: peak force applied [g]     baseline and  ethanol 2g/kg i.p.       • baseline  ...... 119   143         • 30min after ethanol  ...... 74.0   85.9         • change (ethanol effect)  ...... 44.4   57.2         • % change (ethanol effect)  ...... 37.2   39.4         21 strains   age 7-12wks   Inbred

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