Home       About             Help       Phenotype data > 129S1/SvImJ strain > interventions > ethanol (alcohol EtOH)   See also:   Wikipedia Measurements: About these 129S1/SvImJ averages (♀ ♂) Exit 129S1/SvImJ mode behavior — balance and coordination         balance beam   Crabbe1 missteps crossing balance beam [n]     control and  ethanol       12.7mm beam:             • control  ......             i.p. doses g/kg:             • 1.0  ...... 5.33 (N=3) ▲   9.00 (N=2) ▲               • 1.2  ...... 5.00 (N=2) ▲   9.00 (N=3) ▲               • 1.4  ...... 3.00 (N=1)   8.50 (N=2) ▲                 • comparison   8 strains   age 8-16wks   Inbred Crabbe1 missteps crossing balance beam [n]     control and  ethanol       15.8mm beam:             • control  ...... 1.00 (N=3)   3.33 (N=3) ▲▲               i.p. doses g/kg:             • 1.0  ...... 2.10   2.42 (N=4)               • 1.2  ...... 1.89 (N=3)   5.82 (N=3) ▲               • 1.4  ...... 7.07 (N=4) ▲   3.83 (N=2)                 • comparison   8 strains   age 8-16wks   Inbred Crabbe1 missteps crossing balance beam [n]     control and  ethanol       19.0mm beam:             • control  ...... 1.00 (N=3) ▲   1.67 (N=3) ▲               i.p. doses g/kg:             • 1.0  ...... 5.93 (N=4) ▲▲   2.67 (N=3) ▲               • 1.2  ...... 7.68 (N=2) ▲▲   3.42 (N=4) ▲               • 1.4  ...... 8.18 (N=2) ▲▲   2.92 (N=4)                 • comparison   8 strains   age 8-16wks   Inbred   behavior — balance and coordination         dowel balance test   Crabbe4 latency to fall [s]   ethanol   2g/kg i.p.       T0:             • 9.5mm  ...... 81.0 (N=4)   93.0 (N=4)               • 15.8mm  ...... 64.5 (N=4) ▼   119 (N=4)                 • comparison         T30:             • 9.5mm  ...... 13.2 (N=4)   50.0 (N=4)               • 15.8mm  ...... 83.2 (N=4)   5.50 (N=4)                 • comparison   8 strains   age 12-16wks   Inbred   behavior — balance and coordination         grid test   Crabbe1 grid habituation, distance traveled [cm]     control and  ethanol       • control  ...... 105 ▼   229 ▼         i.p. doses g/kg:             • 1.5  ...... 254 (N=3) ▼   248 (N=2) ▼               • 2.0  ...... 375 (N=2) ▼               • 2.5  ...... 383 (N=2)                 • comparison   8 strains   age 8-16wks   Inbred Crabbe1 grid habituation, missteps per cm [n/cm]     control and  ethanol       • control  ...... 0.00150 ▼   0.00564         i.p. doses g/kg:             • 1.5  ...... 0.0813 (N=3)   0.169 (N=2) ▲               • 2.0  ...... 0.150 (N=2)               • 2.5  ...... 0.509 (N=2)                 • comparison   8 strains   age 8-16wks   Inbred   behavior — balance and coordination         parallel rod floor test   Crabbe5 motor incoordination (errors/distance traveled) 1.6mm rod, 6mm space [n/cm]     control and  ethanol       • day1 control  ...... 0.700 ▼   1.12 ▼         • day2 control  ...... 0.377 ▼▼   1.07         • day3 ethanol  ...... 39.9 ▲   38.7 ▲           • comparison   8 strains   age 7-14wks   Inbred   behavior — balance and coordination         rotarod   Crabbe3 fixed speed 3 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg:             • 1  ...... 154 (N=4)   138 (N=3)               • 2  ...... 67.2 (N=4)   117 (N=4) ▲               • 3  ...... 82.3 (N=4)   49.5 (N=3)                 • comparison   9 strains   age 9-17wks   Inbred Crabbe3 fixed speed 6 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg:             • 1  ...... 101 (N=4)   91.8 (N=1)               • 2  ...... 75.8 (N=4)   44.1 (N=4) ▼               • 3  ...... 49.2 (N=4)   42.1 (N=4)                 • comparison   9 strains   age 9-17wks   Inbred Crabbe3 fixed speed 10 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg:             • 1  ...... 105 (N=3)               • 2  ...... 49.5 (N=4)   61.0 (N=4)               • 3  ...... 67.5 (N=4)   52.7 (N=4)                 • comparison   9 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test day 1 20 rpm/min (ARR1) [s]     baseline and  ethanol various i.p.       • baseline  ...... 31.8   32.3         • ethanol  ...... 11.1 ▼   28.4         • Δchange (ethanol effect)  ...... -21.6 ▼   -4.50         8 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test day 2 30 rpm/min (ARR1) [s]     baseline and  ethanol various i.p.       • baseline  ...... 23.2   28.5         • ethanol  ...... 8.14 ▼   24.7         • Δchange (ethanol effect)  ...... -15.3 ▼   -2.68         8 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test 20 rpm/min (ARR2) [s]     baseline and  ethanol 2g/kg i.p.       • baseline  ...... 34.1 ▼   38.9         • ethanol  ...... 20.5 ▼   19.5 ▼         • Δchange (ethanol effect)  ...... -13.7   -19.4         • Δchange (saline control)  ...... -2.95   14.3         21 strains   age 9-17wks   Inbred   behavior — balance and coordination         vertical wire mesh   Crabbe4 latency to fall from a vertical wire mesh grid 30 min post-injection, screen test   [s] ...... 204   217 ▲     ethanol   2g/kg i.p. 8 strains   age 9-10wks   Inbred   behavior — balance and coordination — observer-rated ataxia         observation   Metten1 hindlimb splay, 2.75 g/kg injection [score]   ethanol   2.75g/kg i.p.       • 10min after injection  ...... 3.25 (N=4)   4.00 (N=4) ▲         • 30min after  ...... 2.25 (N=4) ▲   4.75 (N=4) ▲▲           • comparison   9 strains   age 8-11wks   Inbred Metten1 hindlimb splay, 3.0 g/kg injection [score]   ethanol   3.0g/kg i.p.       • 10min after injection  ...... 5.00 (N=4) ▲   3.33 (N=3)         • 30min after  ...... 4.25 (N=4) ▲   3.75 (N=4) ▲           • comparison   9 strains   age 8-11wks   Inbred Metten1 erratic gait, 2.75 g/kg injection [score]   ethanol   2.75g/kg i.p.       • 10min after injection  ...... 0.500 (N=4)   0.250 (N=4)         • 30min after  ...... 0.250 (N=4)   0 (N=4)           • comparison   9 strains   age 8-11wks   Inbred Metten1 erratic gait, 3.0 g/kg injection [score]   ethanol   3.0g/kg i.p.       • 10min after injection  ...... 0 (N=4)   0 (N=3)         • 30min after  ...... 0 (N=4) ▼   0 (N=4) ▼           • comparison   9 strains   age 8-11wks   Inbred Metten1 compare dose groups, hindlimb splay   ethanol         10min after        30min after        9 strains   age 8-11wks   Inbred Metten1 compare dose groups, eratic gait   ethanol         10min after        30min after        9 strains   age 8-11wks   Inbred   behavior — involuntary movement — handling-induced convulsion         observation   Metten2 peak handling-induced convulsion score [score]     control and  ethanol aerosolized       • control  ...... 2.07         • ethanol  ...... 4.43 ▲         • ethanol normalized to controls  ...... 2.36         15 strains   age 8-15wks   Inbred Metten2 latency to first score used to calculate peak ethanol   [h] ...... 3.43     ethanol   aerosolized 15 strains   age 8-15wks   Inbred Metten2 withdrawal severity during 0-25h (area under curve of HIC scores) [AUC]   ethanol   aerosolized       • ethanol  ...... 76.6 ▲         • ethanol normalized to controls  ...... 47.2         15 strains   age 8-15wks   Inbred   behavior — locomotor activity         open field test   Metten1 line crossings, 2.75 g/kg injection [n]     control and  ethanol 2.75g/kg i.p.       • pre-injection  ...... 7.00 (N=4)   4.50 (N=4)         • 10min after injection  ...... 3.50 (N=4) ▼   2.00 (N=4)         • 30min after  ...... 5.75 (N=4)   0 (N=4) ▼           • comparison   9 strains   age 8-11wks   Inbred Metten1 line crossings, 3.0 g/kg injection [n]     control and  ethanol 3.0g/kg i.p.       • pre-injection  ...... 4.00 (N=4)   4.25 (N=4)         • 10min after injection  ...... 0 (N=4) ▼   4.00 (N=3)         • 30min after  ...... 1.50 (N=4) ▼   2.00 (N=4) ▼           • comparison   9 strains   age 8-11wks   Inbred Metten1 line crossings, compare dose groups     control and  ethanol       pre-injection        10min after injection        30min after        9 strains   age 8-11wks   Inbred   behavior — locomotor activity         parallel rod floor test   Crabbe5 distance traveled, 1.6mm rod, 6mm space [cm]     control and  ethanol       • day1 control  ...... 204 ▼   472         • day2 control  ...... 312 ▼   339 ▼         • day3 ethanol  ...... 425 ▼   512 ▼           • comparison   8 strains   age 8-10wks   Inbred   blood — xenobiotics — alcohol concentration         gas chromatography   Crabbe4 blood ethanol concentration (BEC), 35 min post-injection, dowel (15.8 mm) test   [mg/mL] ...... 1.38 (N=4)   1.58 (N=4)     ethanol   2g/kg i.p. 8 strains   age 12-16wks   Inbred Crabbe4 blood ethanol levels following grip strength test at various times after treatment [mg/mL]   ethanol   2g/kg i.p.       time after ethanol:             • 30min  ...... 1.57   1.62               • 60min  ...... 1.95 ▲   1.88 ▲               • 105min  ...... 1.51 ▲   1.58 ▲               • 150min  ...... 0.963 ▲   1.24 ▲▲                 • time comparison   21 strains   age 7-12wks   Inbred   muscle — skeletal — function         grip strength   Crabbe4 grip strength test: peak force applied [g]     baseline and  ethanol 2g/kg i.p.       • baseline  ...... 122   155         • 30min after ethanol  ...... 81.2   59.3         • change (ethanol effect)  ...... 41.0   95.8 ▲▲         • % change (ethanol effect)  ...... 33.6   61.4 ▲         21 strains   age 7-12wks   Inbred

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