Home       About             Help       Phenotype data > AKR/J strain > interventions > ethanol (alcohol EtOH)   See also:   Wikipedia Measurements: About these AKR/J averages (♀ ♂) Exit AKR/J mode behavior — balance and coordination         dowel balance test   Crabbe4 latency to fall [s]   ethanol 2g/kg i.p.       T0:             • 9.5mm  ......             • 15.8mm  ......               • comparison         T30:             • 9.5mm  ......             • 15.8mm  ......               • comparison   8 strains   age 12-16wks   Inbred   behavior — balance and coordination         rotarod   Crabbe3 fixed speed 3 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg:             • 1  ......             • 2  ......             • 3  ......               • comparison   9 strains   age 9-17wks   Inbred Crabbe3 fixed speed 6 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg:             • 1  ......             • 2  ......             • 3  ......               • comparison   9 strains   age 9-17wks   Inbred Crabbe3 fixed speed 10 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg:             • 1  ......             • 2  ......             • 3  ......               • comparison   9 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test day 1 20 rpm/min (ARR1) [s]     baseline and  ethanol       • baseline  ......       • ethanol  ......       • Δchange (ethanol effect)  ......       8 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test day 2 30 rpm/min (ARR1) [s]     baseline and  ethanol       • baseline  ......       • ethanol  ......       • Δchange (ethanol effect)  ......       8 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test 20 rpm/min (ARR2) [s]     baseline and  ethanol 2g/kg i.p.       • baseline  ...... 51.7   56.1         • ethanol  ...... 46.3   63.9 ▲         • Δchange (ethanol effect)  ...... -3.39   7.81 ▲         • Δchange (saline control)  ...... 10.9   29.4 ▲▲         21 strains   age 9-17wks   Inbred   behavior — balance and coordination         vertical wire mesh   Crabbe4 latency to fall from a vertical wire mesh grid 30 min post-injection, screen test   [s] ......   ethanol 2g/kg i.p. 8 strains   age 9-10wks   Inbred   behavior — involuntary movement — handling-induced convulsion         observation   Metten2 peak handling-induced convulsion score [score]     control and  ethanol aerosolized       • control  ...... 0.375         • ethanol  ...... 3.88         • ethanol normalized to controls  ...... 3.50 ▲         15 strains   age 8-15wks   Inbred Metten2 latency to first score used to calculate peak ethanol   [h] ...... 5.75     ethanol aerosolized 15 strains   age 8-15wks   Inbred Metten2 withdrawal severity during 0-25h (area under curve of HIC scores) [AUC]   ethanol aerosolized       • ethanol  ...... 29.7         • ethanol normalized to controls  ...... 53.1         15 strains   age 8-15wks   Inbred   blood — xenobiotics — alcohol concentration         gas chromatography   Crabbe4 blood ethanol concentration (BEC), 35 min post-injection, dowel (15.8 mm) test   [mg/mL] ......   ethanol 2g/kg i.p. 8 strains   age 12-16wks   Inbred Crabbe4 blood ethanol levels following grip strength test at various times after treatment [mg/mL]   ethanol 2g/kg i.p.       time after ethanol:             • 30min  ...... 1.11 ▼   1.36 ▼               • 60min  ...... 1.30 ▼   1.78               • 105min  ...... 0.808 ▼   1.35               • 150min  ...... 0.200 ▼   0.848                 • time comparison   21 strains   age 7-12wks   Inbred   muscle — skeletal — function         grip strength   Crabbe4 grip strength test: peak force applied [g]     baseline and  ethanol 2g/kg i.p.       • baseline  ...... 109   130         • 30min after ethanol  ...... 72.9   68.2         • change (ethanol effect)  ...... 35.9   61.8         • % change (ethanol effect)  ...... 32.8   47.5         21 strains   age 7-12wks   Inbred

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