Home       About             Help       Phenotype data > BTBR T+ tf/J strain > interventions > ethanol (alcohol EtOH)   See also:   Wikipedia Measurements: About these BTBR T+ tf/J averages (♀ ♂) Exit BTBR T+ tf/J mode behavior — balance and coordination         balance beam   Crabbe1 missteps crossing balance beam [n]     control and  ethanol       12.7mm beam:             • control  ...... 0.667 (N=3)   1.33 (N=3)               i.p. doses g/kg:             • 1.0  ...... 2.00   4.50 (N=4)               • 1.2  ...... 5.00 ▲   2.25 (N=4)               • 1.4  ...... 3.25 (N=4)   3.00 (N=2)                 • comparison   8 strains   age 8-16wks   Inbred Crabbe1 missteps crossing balance beam [n]     control and  ethanol       15.8mm beam:             • control  ...... 0.667 (N=3)   0.667 (N=3)               i.p. doses g/kg:             • 1.0  ...... 1.33   2.26               • 1.2  ...... 2.05   3.58 (N=4)               • 1.4  ...... 2.43   2.73                 • comparison   8 strains   age 8-16wks   Inbred Crabbe1 missteps crossing balance beam [n]     control and  ethanol       19.0mm beam:             • control  ...... 0.333 (N=3)   1.00 (N=3)               i.p. doses g/kg:             • 1.0  ...... 0.498 (N=4)   0.583 (N=4)               • 1.2  ...... 1.83 (N=4)   2.58 (N=4)               • 1.4  ...... 2.73   3.06                 • comparison   8 strains   age 8-16wks   Inbred   behavior — balance and coordination         dowel balance test   Crabbe4 latency to fall [s]   ethanol   2g/kg i.p.       T0:             • 9.5mm  ...... 29.7 (N=3) ▼   28.0 (N=3) ▼               • 15.8mm  ...... 102 (N=3)   57.5 (N=2) ▼                 • comparison         T30:             • 9.5mm  ...... 8.33 (N=3)   8.00 (N=3)               • 15.8mm  ...... 5.00 (N=3) ▼   4.00 (N=2)                 • comparison   8 strains   age 12-16wks   Inbred   behavior — balance and coordination         grid test   Crabbe1 grid habituation, distance traveled [cm]     control and  ethanol       • control  ...... 431   612         i.p. doses g/kg:             • 1.5  ...... 999 (N=4)   909 (N=3)               • 2.0  ...... 1004 (N=4)   1300 (N=4)               • 2.5  ...... 1646 (N=3) ▲                 • comparison   8 strains   age 8-16wks   Inbred Crabbe1 grid habituation, missteps per cm [n/cm]     control and  ethanol       • control  ...... 0.00375   0.0103         i.p. doses g/kg:             • 1.5  ...... 0.0192 (N=4)   0.0737 (N=3)               • 2.0  ...... 0.273 (N=4)   0.128 (N=4)               • 2.5  ...... 0.285 (N=3)                 • comparison   8 strains   age 8-16wks   Inbred   behavior — balance and coordination         parallel rod floor test   Crabbe5 motor incoordination (errors/distance traveled) 1.6mm rod, 6mm space [n/cm]     control and  ethanol       • day1 control  ...... 2.87   1.96         • day2 control  ...... 2.71   1.93         • day3 ethanol  ...... 20.5   24.0           • comparison   8 strains   age 7-14wks   Inbred   behavior — balance and coordination         rotarod   Crabbe3 fixed speed 3 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg:             • 1  ...... 180 (N=2)   114 (N=2) ▼               • 2  ...... 158 (N=4) ▲               • 3  ...... 84.4 (N=3)   49.8 (N=2)                 • comparison   9 strains   age 9-17wks   Inbred Crabbe3 fixed speed 6 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg:             • 1  ...... 162 (N=3) ▲   171 (N=2) ▲               • 2  ...... 111 (N=3)               • 3  ...... 53.2 (N=3)   117 (N=2) ▲▲                 • comparison   9 strains   age 9-17wks   Inbred Crabbe3 fixed speed 10 rpm rotarod (latency to fall) [s]   ethanol       ethanol i.p. g/kg:             • 1  ...... 116 (N=3) ▲   94.8 (N=1)               • 2  ...... 56.1 (N=3)               • 3  ...... 39.0 (N=3) ▼   57.1 (N=1)                 • comparison   9 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test day 1 20 rpm/min (ARR1) [s]     baseline and  ethanol various i.p.       • baseline  ...... 52.9 ▲   50.6 (N=4) ▲▲         • ethanol  ...... 37.4   8.20 (N=2) ▼         • Δchange (ethanol effect)  ...... -15.5 ▼   -39.9 (N=2) ▼         8 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test day 2 30 rpm/min (ARR1) [s]     baseline and  ethanol various i.p.       • baseline  ...... 52.3 ▲▲   37.7 (N=3) ▲         • ethanol  ...... 40.0 (N=3) ▲   29.5 (N=2)         • Δchange (ethanol effect)  ...... -19.8 (N=3) ▼   -12.2 (N=2) ▼         8 strains   age 9-17wks   Inbred Crabbe3 accelerating rotarod (latency to fall) - test 20 rpm/min (ARR2) [s]     baseline and  ethanol 2g/kg i.p.       • baseline  ...... 63.2   60.0         • ethanol  ...... 22.6 ▼   17.0 ▼         • Δchange (ethanol effect)  ...... -40.5 ▼   -43.0 ▼         • Δchange (saline control)  ...... 5.88   -2.42         21 strains   age 9-17wks   Inbred   behavior — balance and coordination         vertical wire mesh   Crabbe4 latency to fall from a vertical wire mesh grid 30 min post-injection, screen test   [s] ...... 104 ▼   71.2 (N=4) ▼     ethanol   2g/kg i.p. 8 strains   age 9-10wks   Inbred   behavior — balance and coordination — observer-rated ataxia         observation   Metten1 hindlimb splay, 2.75 g/kg injection [score]   ethanol   2.75g/kg i.p.       • 10min after injection  ...... 2.75 (N=4)   3.33 (N=3)         • 30min after  ...... 1.75 (N=4) ▲   1.00 (N=4)           • comparison   9 strains   age 8-11wks   Inbred Metten1 hindlimb splay, 3.0 g/kg injection [score]   ethanol   3.0g/kg i.p.       • 10min after injection  ...... 3.75 (N=4)   2.50 (N=4)         • 30min after  ...... 3.75 (N=4)   1.00 (N=4)           • comparison   9 strains   age 8-11wks   Inbred Metten1 erratic gait, 2.75 g/kg injection [score]   ethanol   2.75g/kg i.p.       • 10min after injection  ...... 0.250 (N=4)   0 (N=3)         • 30min after  ...... 0.250 (N=4)   0 (N=4)           • comparison   9 strains   age 8-11wks   Inbred Metten1 erratic gait, 3.0 g/kg injection [score]   ethanol   3.0g/kg i.p.       • 10min after injection  ...... 0 (N=4)   0 (N=4)         • 30min after  ...... 0 (N=4) ▼   0.250 (N=4)           • comparison   9 strains   age 8-11wks   Inbred Metten1 compare dose groups, hindlimb splay   ethanol         10min after        30min after        9 strains   age 8-11wks   Inbred Metten1 compare dose groups, eratic gait   ethanol         10min after        30min after        9 strains   age 8-11wks   Inbred   behavior — involuntary movement — handling-induced convulsion         observation   Metten2 peak handling-induced convulsion score [score]     control and  ethanol aerosolized       • control  ...... 0.468         • ethanol  ...... 3.53         • ethanol normalized to controls  ...... 3.07         15 strains   age 8-15wks   Inbred Metten2 latency to first score used to calculate peak ethanol   [h] ...... 5.80     ethanol   aerosolized 15 strains   age 8-15wks   Inbred Metten2 withdrawal severity during 0-25h (area under curve of HIC scores) [AUC]   ethanol   aerosolized       • ethanol  ...... 36.6         • ethanol normalized to controls  ...... 49.5         15 strains   age 8-15wks   Inbred   behavior — locomotor activity         open field test   Metten1 line crossings, 2.75 g/kg injection [n]     control and  ethanol 2.75g/kg i.p.       • pre-injection  ...... 21.8 (N=4) ▲   23.2 (N=4) ▲▲         • 10min after injection  ...... 12.0 (N=4)   6.00 (N=3)         • 30min after  ...... 14.0 (N=4)   9.00 (N=4)           • comparison   9 strains   age 8-11wks   Inbred Metten1 line crossings, 3.0 g/kg injection [n]     control and  ethanol 3.0g/kg i.p.       • pre-injection  ...... 28.0 (N=4) ▲   27.0 (N=3) ▲         • 10min after injection  ...... 0.500 (N=4)   8.50 (N=4)         • 30min after  ...... 3.50 (N=4)   16.2 (N=4)           • comparison   9 strains   age 8-11wks   Inbred Metten1 line crossings, compare dose groups     control and  ethanol       pre-injection        10min after injection        30min after        9 strains   age 8-11wks   Inbred   behavior — locomotor activity         parallel rod floor test   Crabbe5 distance traveled, 1.6mm rod, 6mm space [cm]     control and  ethanol       • day1 control  ...... 690   639         • day2 control  ...... 702   720         • day3 ethanol  ...... 1674 ▲   1535           • comparison   8 strains   age 8-10wks   Inbred   blood — xenobiotics — alcohol concentration         gas chromatography   Crabbe4 blood ethanol concentration (BEC), 35 min post-injection, dowel (15.8 mm) test   [mg/mL] ...... 1.22 (N=3) ▼   1.97 (N=2)     ethanol   2g/kg i.p. 8 strains   age 12-16wks   Inbred Crabbe4 blood ethanol levels following grip strength test at various times after treatment [mg/mL]   ethanol   2g/kg i.p.       time after ethanol:             • 30min  ...... 1.24   1.46               • 60min  ...... 1.43   1.67               • 105min  ...... 1.17   1.20               • 150min  ...... 0.544   0.716                 • time comparison   21 strains   age 7-12wks   Inbred   muscle — skeletal — function         grip strength   Crabbe4 grip strength test: peak force applied [g]     baseline and  ethanol 2g/kg i.p.       • baseline  ...... 58.0 ▼▼   115         • 30min after ethanol  ...... 48.7 ▼   67.0         • change (ethanol effect)  ...... 62.2 (N=2) ▲   47.6         • % change (ethanol effect)  ...... 51.5 (N=2) ▲   40.4         21 strains   age 7-12wks   Inbred

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