Home       About             Help       Phenotype data > C3H/HeJ strain > interventions > diazepam (anxiety reliever e.g. Valium)   See also:   Wikipedia Measurements: About these C3H/HeJ averages (♀ ♂) Exit C3H/HeJ mode behavior — balance and coordination         rotarod   Crabbe2 latency to fall from 5 rpm rotarod, 0 min post-injection [s]   diazepam   20 mg/kg       • trial block1  ...... 112         • trial block2  ......         • comparison   15 strains   age 6-7wks   Inbred   behavior — locomotor activity         monitoring system   Crabbe2 horizontal distance traveled (immediately to 15 min post-injection) [cm]     baseline and  diazepam       • baseline  ...... 2513         doses mg/kg:             • 2  ...... 3128               • 4  ...... 3690               • 8  ...... 2791               • 16  ...... 1483                 • comparison   15 strains   age 6-7wks   Inbred Crabbe2 vertical (rearing) activity (immediately to 15 min post-injection) [n]     baseline and  diazepam       • baseline  ...... 212         doses mg/kg:             • 2  ...... 29.0               • 4  ...... 17.0               • 8  ...... 19.0               • 16  ...... 7.00                 • comparison   15 strains   age 6-7wks   Inbred   brain — xenobiotics — drug and metabolite concentration         gas chromatography   Crabbe2 brain diazepam and metabolite concentration (30 min post-injection) [ng/g]   diazepam       • 8 mg/kg  ...... 5.00 ▲         • 16 mg/kg  ...... 12.7 ▲           • comparison   15 strains   age 6-7wks   Inbred Crabbe2 brain diazepam and metabolite concentration (<5 min post-injection) after rotarod [ng/g]   diazepam   20 mg/kg       • trial block1  ...... 0.500         • trial block2  ......         • comparison   15 strains   age 6-7wks   Inbred   metabolism — body temperature         thermometer   Crabbe2 body temperature (30 min post-injection) [°C]     baseline and  diazepam       • baseline  ...... 37.6 ▼▼         doses mg/kg:             • 2  ...... 37.4               • 4  ...... 36.9               • 8  ...... 37.1               • 16  ...... 36.3                 • comparison   15 strains   age 6-7wks   Inbred

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