Home       About             Help       Phenotype data > SJL/J strain > interventions > diazepam (anxiety reliever e.g. Valium)   See also:   Wikipedia Measurements: About these SJL/J averages (♀ ♂) Exit SJL/J mode behavior — balance and coordination         rotarod   Crabbe2 latency to fall from 5 rpm rotarod, 0 min post-injection [s]   diazepam   20 mg/kg       • trial block1  ......       • trial block2  ...... 0 ▼           • comparison   15 strains   age 6-7wks   Inbred   behavior — locomotor activity         monitoring system   Crabbe2 horizontal distance traveled (immediately to 15 min post-injection) [cm]     baseline and  diazepam       • baseline  ...... 3193         doses mg/kg:             • 2  ...... 7190 ▲▲               • 4  ...... 8001 ▲               • 8  ...... 11093 ▲               • 16  ...... 6503 ▲                 • comparison   15 strains   age 6-7wks   Inbred Crabbe2 vertical (rearing) activity (immediately to 15 min post-injection) [n]     baseline and  diazepam       • baseline  ...... 200         doses mg/kg:             • 2  ...... 297               • 4  ...... 260 ▲               • 8  ...... 167               • 16  ...... 64.0                 • comparison   15 strains   age 6-7wks   Inbred   brain — xenobiotics — drug and metabolite concentration         gas chromatography   Crabbe2 brain diazepam and metabolite concentration (30 min post-injection) [ng/g]   diazepam       • 8 mg/kg  ...... 3.70         • 16 mg/kg  ...... 9.20           • comparison   15 strains   age 6-7wks   Inbred Crabbe2 brain diazepam and metabolite concentration (<5 min post-injection) after rotarod [ng/g]   diazepam   20 mg/kg       • trial block1  ......       • trial block2  ...... 0.300 ▼           • comparison   15 strains   age 6-7wks   Inbred   metabolism — body temperature         thermometer   Crabbe2 body temperature (30 min post-injection) [°C]     baseline and  diazepam       • baseline  ...... 38.3 ▲         doses mg/kg:             • 2  ...... 37.9 ▲               • 4  ...... 37.9 ▲               • 8  ...... 37.4               • 16  ...... 37.5 ▲                 • comparison   15 strains   age 6-7wks   Inbred

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