Home       About             Help       Phenotype data > AKR/J strain > interventions > diazepam (anxiety reliever e.g. Valium)   See also:   Wikipedia Measurements: About these AKR/J averages (♀ ♂) Exit AKR/J mode behavior — balance and coordination         rotarod   Crabbe2 latency to fall from 5 rpm rotarod, 0 min post-injection [s]   diazepam 20 mg/kg       • trial block1  ...... 261 ▲▲         • trial block2  ......         • comparison   15 strains   age 6-7wks   Inbred   behavior — locomotor activity         monitoring system   Crabbe2 horizontal distance traveled (immediately to 15 min post-injection) [cm]     baseline and  diazepam       • baseline  ...... 3951         doses mg/kg:             • 2  ...... 4627               • 4  ...... 5464               • 8  ...... 6587               • 16  ...... 2079                 • comparison   15 strains   age 6-7wks   Inbred Crabbe2 vertical (rearing) activity (immediately to 15 min post-injection) [n]     baseline and  diazepam       • baseline  ...... 153         doses mg/kg:             • 2  ...... 31.0               • 4  ...... 28.0               • 8  ...... 2.00               • 16  ...... 3.00                 • comparison   15 strains   age 6-7wks   Inbred   brain — xenobiotics — drug and metabolite concentration         gas chromatography   Crabbe2 brain diazepam and metabolite concentration (30 min post-injection) [ng/g]   diazepam       • 8 mg/kg  ...... 4.50         • 16 mg/kg  ...... 8.40           • comparison   15 strains   age 6-7wks   Inbred Crabbe2 brain diazepam and metabolite concentration (<5 min post-injection) after rotarod [ng/g]   diazepam 20 mg/kg       • trial block1  ...... 1.80 ▲▲         • trial block2  ......         • comparison   15 strains   age 6-7wks   Inbred   metabolism — body temperature         thermometer   Crabbe2 body temperature (30 min post-injection) [°C]     baseline and  diazepam       • baseline  ...... 38.0         doses mg/kg:             • 2  ...... 36.8               • 4  ...... 36.6               • 8  ...... 36.4               • 16  ...... 36.4                 • comparison   15 strains   age 6-7wks   Inbred

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