Home       About             Help       Phenotype data > CZECHII/EiJ strain > interventions > acetaminophen (pain reliever e.g. Tylenol)   See also:   Wikipedia Measurements: About these CZECHII/EiJ averages (♀ ♂) Exit CZECHII/EiJ mode blood — clinical chemistry — enzymes — ALT         metabolic panel   Threadgill1 alanine aminotransferase (serum ALT) [IU/L]     control and  acetaminophen       100 mg/kg:             • control  ...... 24.0 (N=2)               • 4h  ......             • 12h  ......             • 24h  ......               • time comparison   37 strains   age 8-17wks   Inbred   blood — clinical chemistry — enzymes — AST         metabolic panel   Threadgill1 aspartate aminotransferase (serum AST) [IU/L]     control and  acetaminophen       • control  ...... 150 (N=3)         post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 692 (N=3)                 • comparison   37 strains   age 8-17wks   Inbred   blood — clinical chemistry — urea nitrogen         metabolic panel   Threadgill1 blood urea nitrogen (BUN) [mg/dL]     control and  acetaminophen       • control  ...... 20.7 (N=3)         post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 14.0 (N=2)                 • comparison   36 strains   age 8-17wks   Inbred   liver — enzyme homeostasis         ELISA   Threadgill1 cytochrome P450 1A2 isoform [pmol/mg]     control and  acetaminophen 300 mg/kg       • control  ...... 210 (N=1)         • post-Rx 300 mg/kg  ...... 149 (N=3)           • comparison   36 strains   age 8-12wks   Inbred Threadgill1 cytochrome P450 2E1 isoform [pmol/mg]     control and  acetaminophen 300 mg/kg       • control  ...... 59.0 (N=2) ▼         • post-Rx 300 mg/kg  ...... 70.6 (N=3)           • comparison   36 strains   age 8-12wks   Inbred   liver — enzyme homeostasis         HPLC   Threadgill1 glutathione transferase [µg/mL]     control and  acetaminophen 300 mg/kg       • control  ...... 837 (N=3)         • post-Rx 300 mg/kg  ...... 927 (N=3)         36 strains   age 8-12wks   Inbred   liver — enzyme homeostasis         metabolic panel   Threadgill1 catalase [µg/mL]     control and  acetaminophen 300 mg/kg       • control  ...... 479 (N=3)         • post-Rx 300 mg/kg  ...... 342 (N=3)           • comparison   36 strains   age 8-12wks   Inbred   liver — pathology         histopathology   Threadgill1 necrosis [%]     control and  acetaminophen       • control  ...... 0 (N=3)         post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 5.00 (N=3) ▼                 • comparison   37 strains   age 8-17wks   Inbred   liver — protein homeostasis — glutathione         HPLC   Threadgill1 reduced glutathione (GSH) [µmol/g]     control and  acetaminophen       • control  ...... 3.77 (N=1)         • post-Rx 300mg/kg  ...... 3.57 (N=3)           • comparison   35 strains   age 8-17wks   Inbred Threadgill1 oxidized glutathione (GSSG) [µmol/g]     control and  acetaminophen       • control  ...... 0.115 (N=1)         • post-Rx 300mg/kg  ...... 0.0987 (N=3)           • comparison   35 strains   age 8-17wks   Inbred Threadgill1 total glutathione (GSH plus GSSG) [µmol/g]     control and  acetaminophen       • control  ...... 4.00 (N=1)         • post-Rx 300 mg/kg  ...... 3.77 (N=3)           • comparison   37 strains   age 8-17wks   Inbred Threadgill1 ratio of reduced (GSH) to oxidized (GSSG) glutathione [ratio]     control and  acetaminophen       • control  ...... 32.8 (N=1)         • post-Rx 300mg/kg  ...... 35.3 (N=3)           • comparison   35 strains   age 8-17wks   Inbred   liver — weight         scales   Threadgill1 liver weight [g]     control and  acetaminophen       • control  ...... 0.660 ▼         24h post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 0.857 (N=3) ▼                 • comparison   37 strains   age 8-17wks   Inbred

Video tutorial session 2 explains the use of this page.

Hosted by:

Contact us About MPD Also at JAX

Units Changelog Downloads

Citing Funding Terms of Use