Home       About             Help       Phenotype data > NZW/LacJ strain > interventions > acetaminophen (pain reliever e.g. Tylenol)   See also:   Wikipedia Measurements: About these NZW/LacJ averages (♀ ♂) Exit NZW/LacJ mode blood — clinical chemistry — enzymes — ALT         metabolic panel   Threadgill1 alanine aminotransferase (serum ALT) [IU/L]     control and  acetaminophen       100 mg/kg:             • control  ...... 30.0 (N=2)               • 4h  ......             • 12h  ......             • 24h  ......               • time comparison   37 strains   age 8-17wks   Inbred Threadgill2 alanine aminotransferase (serum ALT) [IU/L]   acetaminophen 50mg/kg       • 50 mg/kg  ...... 37.0 (N=4)         • 300 mg/kg  ...... 2691 (N=4) ▼           • comparison   5 strains   age 6-8wks   Inbred   blood — clinical chemistry — enzymes — AST         metabolic panel   Threadgill1 aspartate aminotransferase (serum AST) [IU/L]     control and  acetaminophen       • control  ...... 98.0 (N=2)         post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 2845 (N=4)                 • comparison   37 strains   age 8-17wks   Inbred   blood — clinical chemistry — urea nitrogen         metabolic panel   Threadgill1 blood urea nitrogen (BUN) [mg/dL]     control and  acetaminophen       • control  ...... 17.5 (N=2)         post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 21.3 (N=3)                 • comparison   36 strains   age 8-17wks   Inbred   blood — xenobiotics — drug and metabolite concentration         HPLC   Threadgill2 serum acetominophen (APAP) [µg/mL]     baseline and  acetaminophen 50mg/kg       • baseline  ...... 2.37         • 0.5h  ...... 2.36 ▼         • 1h  ...... 1.40         • 2h  ...... 0.482         • 3h  ...... 0.297 (N=4) ▼         • 6h  ...... 0.177 (N=4)           • time comparison   5 strains   age 6-8wks   Inbred Threadgill2 serum acetaminophen sulfate (APAP-sulfate) [µg/mL]     baseline and  acetaminophen 50mg/kg       • baseline  ...... 2.05         • 0.5h  ...... 4.84 ▼         • 1h  ...... 2.78         • 2h  ...... 1.74         • 3h  ...... 1.78 (N=4)         • 6h  ...... 2.04 (N=4)           • time comparison   5 strains   age 6-8wks   Inbred Threadgill2 serum acetaminophen glucuronide (APAP-Glc) [µg/mL]     baseline and  acetaminophen 50mg/kg       • baseline  ...... 2.54 (N=2)         • 0.5h  ...... 20.5         • 1h  ...... 15.0         • 2h  ...... 5.99         • 3h  ...... 3.86 (N=4)         • 6h  ...... 0.800 (N=2) ▼           • time comparison   5 strains   age 6-8wks   Inbred Threadgill2 serum acetominophen (APAP) [µg/mL]     baseline and  acetaminophen 300mg/kg       • baseline  ...... 16.9         • 0.5h  ...... 47.3 ▼         • 1h  ...... 36.8         • 2h  ...... 11.9         • 3h  ...... 5.94 (N=4)         • 6h  ...... 3.61           • time comparison   5 strains   age 6-8wks   Inbred Threadgill2 serum acetaminophen sulfate (APAP-sulfate) [µg/mL]     baseline and  acetaminophen 300mg/kg       • baseline  ...... 4.26 ▲         • 0.5h  ...... 18.7         • 1h  ...... 26.3 ▲         • 2h  ...... 19.8         • 3h  ...... 15.2 (N=4)         • 6h  ...... 5.66           • time comparison   5 strains   age 6-8wks   Inbred Threadgill2 serum acetaminophen glucuronide (APAP-Glc) [µg/mL]     baseline and  acetaminophen 300mg/kg       • baseline  ...... 14.9         • 0.5h  ...... 261         • 1h  ...... 357         • 2h  ...... 196         • 3h  ...... 100 (N=4)         • 6h  ...... 24.9           • time comparison   5 strains   age 6-8wks   Inbred   liver — enzyme homeostasis         ELISA   Threadgill1 cytochrome P450 1A2 isoform [pmol/mg]     control and  acetaminophen 300 mg/kg       • control  ...... 191 (N=2)         • post-Rx 300 mg/kg  ...... 153 (N=3)           • comparison   36 strains   age 8-12wks   Inbred Threadgill1 cytochrome P450 2E1 isoform [pmol/mg]     control and  acetaminophen 300 mg/kg       • control  ...... 117 (N=2)         • post-Rx 300 mg/kg  ...... 76.7 (N=3)           • comparison   36 strains   age 8-12wks   Inbred   liver — enzyme homeostasis         HPLC   Threadgill1 glutathione transferase [µg/mL]     control and  acetaminophen 300 mg/kg       • control  ...... 662 (N=2)         • post-Rx 300 mg/kg  ...... 407 (N=4) ▼         36 strains   age 8-12wks   Inbred   liver — enzyme homeostasis         metabolic panel   Threadgill1 catalase [µg/mL]     control and  acetaminophen 300 mg/kg       • control  ...... 429 (N=2)         • post-Rx 300 mg/kg  ...... 468 (N=4)           • comparison   36 strains   age 8-12wks   Inbred   liver — pathology         histopathology   Threadgill1 necrosis [%]     control and  acetaminophen       • control  ...... 10.0 (N=2) ▲▲         post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 45.8 (N=4) ▲                 • comparison   37 strains   age 8-17wks   Inbred Threadgill2 liver necrosis score   [%] ...... 48.6     acetaminophen 300mg/kg 5 strains   age 6-8wks   Inbred Threadgill2 percent nitrotyrosine staining (marker of hepatocyte injury)   [%] ...... 48.4     acetaminophen 300mg/kg 5 strains   age 6-8wks   Inbred   liver — protein homeostasis — glutathione         HPLC   Threadgill1 reduced glutathione (GSH) [µmol/g]     control and  acetaminophen       • control  ...... 6.04 (N=2)         • post-Rx 300mg/kg  ...... 1.70           • comparison   35 strains   age 8-17wks   Inbred Threadgill1 oxidized glutathione (GSSG) [µmol/g]     control and  acetaminophen       • control  ...... -0.0598 (N=2) ▼▼         • post-Rx 300mg/kg  ...... 0.0769           • comparison   35 strains   age 8-17wks   Inbred Threadgill1 total glutathione (GSH plus GSSG) [µmol/g]     control and  acetaminophen       • control  ...... 5.92 (N=2)         • post-Rx 300 mg/kg  ...... 1.85           • comparison   37 strains   age 8-17wks   Inbred Threadgill1 ratio of reduced (GSH) to oxidized (GSSG) glutathione [ratio]     control and  acetaminophen       • control  ...... 9.95 (N=2)         • post-Rx 300mg/kg  ...... 25.1           • comparison   35 strains   age 8-17wks   Inbred Threadgill2 reduced glutathione (GSH) [µmol/mg]     control and  acetaminophen 300mg/kg       • control  ...... 10.1 (N=3)         • post-Rx 300 mg/kg  ...... 8.48           • comparison   5 strains   age 6-8wks   Inbred Threadgill2 percent reduced glutathione [%]     control and  acetaminophen 300mg/kg       • control  ...... 135 (N=3)         • post-Rx 300 mg/kg  ...... 97.2           • comparison   5 strains   age 6-8wks   Inbred Threadgill2 total glutathione [µmol/mg]     control and  acetaminophen 300mg/kg       • control  ...... 7.50 (N=3)         • post-Rx 300 mg/kg  ...... 10.3           • comparison   5 strains   age 6-8wks   Inbred   liver — weight         scales   Threadgill1 liver weight [g]     control and  acetaminophen       • control  ...... 1.67 (N=4) ▲         24h post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 1.92 (N=4) ▲                 • comparison   37 strains   age 8-17wks   Inbred

Video tutorial session 2 explains the use of this page.

Contact us About MPD Also at JAX

Units Changelog Downloads

Citing Funding Terms of Use