Home       About             Help       Phenotype data > 129S1/SvImJ strain > interventions > acetaminophen (pain reliever e.g. Tylenol)   See also:   Wikipedia Measurements: About these 129S1/SvImJ averages (♀ ♂) Exit 129S1/SvImJ mode blood — clinical chemistry — enzymes — ALT         metabolic panel   Threadgill1 alanine aminotransferase (serum ALT) [IU/L]     control and  acetaminophen       100 mg/kg:             • control  ...... 28.7 (N=3)               • 4h  ......             • 12h  ......             • 24h  ......               • time comparison   37 strains   age 8-17wks   Inbred   blood — clinical chemistry — enzymes — AST         metabolic panel   Threadgill1 aspartate aminotransferase (serum AST) [IU/L]     control and  acetaminophen       • control  ...... 117 (N=2)         post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 8920 (N=4) ▲                 • comparison   37 strains   age 8-17wks   Inbred   blood — clinical chemistry — urea nitrogen         metabolic panel   Threadgill1 blood urea nitrogen (BUN) [mg/dL]     control and  acetaminophen       • control  ...... 23.5 (N=2) ▲         post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 33.2 (N=4)                 • comparison   36 strains   age 8-17wks   Inbred   liver — enzyme homeostasis         ELISA   Threadgill1 cytochrome P450 1A2 isoform [pmol/mg]     control and  acetaminophen 300 mg/kg       • control  ...... 200 (N=2)         • post-Rx 300 mg/kg  ...... 288 (N=3) ▲▲           • comparison   36 strains   age 8-12wks   Inbred Threadgill1 cytochrome P450 2E1 isoform [pmol/mg]     control and  acetaminophen 300 mg/kg       • control  ...... 152 (N=2)         • post-Rx 300 mg/kg  ...... 157 (N=3) ▲▲           • comparison   36 strains   age 8-12wks   Inbred   liver — enzyme homeostasis         HPLC   Threadgill1 glutathione transferase [µg/mL]     control and  acetaminophen 300 mg/kg       • control  ...... 919 (N=2)         • post-Rx 300 mg/kg  ...... 993 (N=3)         36 strains   age 8-12wks   Inbred   liver — enzyme homeostasis         metabolic panel   Threadgill1 catalase [µg/mL]     control and  acetaminophen 300 mg/kg       • control  ...... 610 (N=2)         • post-Rx 300 mg/kg  ...... 662 (N=3) ▲           • comparison   36 strains   age 8-12wks   Inbred   liver — pathology         histopathology   Threadgill1 necrosis [%]     control and  acetaminophen       • control  ...... 0 (N=2)         post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 31.2 (N=4)                 • comparison   37 strains   age 8-17wks   Inbred   liver — protein homeostasis — glutathione         HPLC   Threadgill1 reduced glutathione (GSH) [µmol/g]     control and  acetaminophen       • control  ...... 5.07 (N=3)         • post-Rx 300mg/kg  ...... 2.82           • comparison   35 strains   age 8-17wks   Inbred Threadgill1 oxidized glutathione (GSSG) [µmol/g]     control and  acetaminophen       • control  ...... 0.252 (N=3)         • post-Rx 300mg/kg  ...... 0.162           • comparison   35 strains   age 8-17wks   Inbred Threadgill1 total glutathione (GSH plus GSSG) [µmol/g]     control and  acetaminophen       • control  ...... 5.57 (N=3)         • post-Rx 300 mg/kg  ...... 3.15           • comparison   37 strains   age 8-17wks   Inbred Threadgill1 ratio of reduced (GSH) to oxidized (GSSG) glutathione [ratio]     control and  acetaminophen       • control  ...... 19.4 (N=3)         • post-Rx 300mg/kg  ...... 16.4           • comparison   35 strains   age 8-17wks   Inbred   liver — weight         scales   Threadgill1 liver weight [g]     control and  acetaminophen       • control  ...... 0.984         24h post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 1.00 (N=4)                 • comparison   37 strains   age 8-17wks   Inbred

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