Home       About             Help       Phenotype data > BUB/BnJ strain > interventions > acetaminophen (pain reliever e.g. Tylenol)   See also:   Wikipedia Measurements: About these BUB/BnJ averages (♀ ♂) Exit BUB/BnJ mode blood — clinical chemistry — enzymes — ALT         metabolic panel   Threadgill1 alanine aminotransferase (serum ALT) [IU/L]     control and  acetaminophen       100 mg/kg:             • control  ...... 56.5 (N=2)               • 4h  ......             • 12h  ......             • 24h  ......               • time comparison   37 strains   age 8-17wks   Inbred   blood — clinical chemistry — enzymes — AST         metabolic panel   Threadgill1 aspartate aminotransferase (serum AST) [IU/L]     control and  acetaminophen       • control  ...... 92.0 (N=3)         post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 1296 (N=3)                 • comparison   37 strains   age 8-17wks   Inbred   blood — clinical chemistry — urea nitrogen         metabolic panel   Threadgill1 blood urea nitrogen (BUN) [mg/dL]     control and  acetaminophen       • control  ...... 18.7 (N=3)         post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 14.3 (N=3)                 • comparison   36 strains   age 8-17wks   Inbred   liver — enzyme homeostasis         ELISA   Threadgill1 cytochrome P450 1A2 isoform [pmol/mg]     control and  acetaminophen 300 mg/kg       • control  ...... 132 (N=1)         • post-Rx 300 mg/kg  ...... 134 (N=3)           • comparison   36 strains   age 8-12wks   Inbred Threadgill1 cytochrome P450 2E1 isoform [pmol/mg]     control and  acetaminophen 300 mg/kg       • control  ...... 112 (N=1)         • post-Rx 300 mg/kg  ...... 50.3 (N=3)           • comparison   36 strains   age 8-12wks   Inbred   liver — enzyme homeostasis         HPLC   Threadgill1 glutathione transferase [µg/mL]     control and  acetaminophen 300 mg/kg       • control  ...... 1056 (N=3)         • post-Rx 300 mg/kg  ...... 1281 (N=3) ▲         36 strains   age 8-12wks   Inbred   liver — enzyme homeostasis         metabolic panel   Threadgill1 catalase [µg/mL]     control and  acetaminophen 300 mg/kg       • control  ...... 364 (N=3)         • post-Rx 300 mg/kg  ...... 381 (N=3)           • comparison   36 strains   age 8-12wks   Inbred   liver — pathology         histopathology   Threadgill1 necrosis [%]     control and  acetaminophen       • control  ...... 0 (N=3)         post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 43.7 (N=3)                 • comparison   37 strains   age 8-17wks   Inbred   liver — protein homeostasis — glutathione         HPLC   Threadgill1 reduced glutathione (GSH) [µmol/g]     control and  acetaminophen       • control  ...... 6.48 (N=2) ▲         • post-Rx 300mg/kg  ...... 3.02 (N=4)           • comparison   35 strains   age 8-17wks   Inbred Threadgill1 oxidized glutathione (GSSG) [µmol/g]     control and  acetaminophen       • control  ...... -0.145 (N=2) ▼▼         • post-Rx 300mg/kg  ...... -0.0130 (N=4) ▼           • comparison   35 strains   age 8-17wks   Inbred Threadgill1 total glutathione (GSH plus GSSG) [µmol/g]     control and  acetaminophen       • control  ...... 6.20 (N=2)         • post-Rx 300 mg/kg  ...... 3.00 (N=4)           • comparison   37 strains   age 8-17wks   Inbred Threadgill1 ratio of reduced (GSH) to oxidized (GSSG) glutathione [ratio]     control and  acetaminophen       • control  ...... -43.9 (N=2) ▼▼         • post-Rx 300mg/kg  ...... -32.5 (N=4) ▼▼           • comparison   35 strains   age 8-17wks   Inbred   liver — weight         scales   Threadgill1 liver weight [g]     control and  acetaminophen       • control  ...... 1.52 ▲         24h post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 1.60 (N=3) ▲                 • comparison   37 strains   age 8-17wks   Inbred

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