Home       About             Help       Phenotype data > PL/J strain > interventions > acetaminophen (pain reliever e.g. Tylenol)   See also:   Wikipedia Measurements: About these PL/J averages (♀ ♂) Exit PL/J mode blood — clinical chemistry — enzymes — ALT         metabolic panel   Threadgill1 alanine aminotransferase (serum ALT) [IU/L]     control and  acetaminophen       100 mg/kg:             • control  ...... 48.0 (N=2)               • 4h  ......             • 12h  ......             • 24h  ......               • time comparison   37 strains   age 8-17wks   Inbred   blood — clinical chemistry — enzymes — AST         metabolic panel   Threadgill1 aspartate aminotransferase (serum AST) [IU/L]     control and  acetaminophen       • control  ...... 95.5 (N=2)         post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 1217 (N=3)                 • comparison   37 strains   age 8-17wks   Inbred   blood — clinical chemistry — urea nitrogen         metabolic panel   Threadgill1 blood urea nitrogen (BUN) [mg/dL]     control and  acetaminophen       • control  ...... 16.5 (N=2)         post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 17.0 (N=2)                 • comparison   36 strains   age 8-17wks   Inbred   liver — enzyme homeostasis         ELISA   Threadgill1 cytochrome P450 1A2 isoform [pmol/mg]     control and  acetaminophen 300 mg/kg       • control  ...... 186 (N=1)         • post-Rx 300 mg/kg  ...... 120 (N=4)           • comparison   36 strains   age 8-12wks   Inbred Threadgill1 cytochrome P450 2E1 isoform [pmol/mg]     control and  acetaminophen 300 mg/kg       • control  ...... 84.0 (N=2)         • post-Rx 300 mg/kg  ...... 44.5 (N=4) ▼           • comparison   36 strains   age 8-12wks   Inbred   liver — enzyme homeostasis         HPLC   Threadgill1 glutathione transferase [µg/mL]     control and  acetaminophen 300 mg/kg       • control  ...... 376 (N=2) ▼         • post-Rx 300 mg/kg  ...... 412 (N=4) ▼         36 strains   age 8-12wks   Inbred   liver — enzyme homeostasis         metabolic panel   Threadgill1 catalase [µg/mL]     control and  acetaminophen 300 mg/kg       • control  ...... 400 (N=2)         • post-Rx 300 mg/kg  ...... 353 (N=4)           • comparison   36 strains   age 8-12wks   Inbred   liver — pathology         histopathology   Threadgill1 necrosis [%]     control and  acetaminophen       • control  ...... 0 (N=2)         post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 10.7 (N=3)                 • comparison   37 strains   age 8-17wks   Inbred   liver — protein homeostasis — glutathione         HPLC   Threadgill1 reduced glutathione (GSH) [µmol/g]     control and  acetaminophen       • control  ...... 5.10 (N=2)         • post-Rx 300mg/kg  ...... 1.60 (N=4)           • comparison   35 strains   age 8-17wks   Inbred Threadgill1 oxidized glutathione (GSSG) [µmol/g]     control and  acetaminophen       • control  ...... 0.380 (N=2) ▲         • post-Rx 300mg/kg  ...... 0.118 (N=4)           • comparison   35 strains   age 8-17wks   Inbred Threadgill1 total glutathione (GSH plus GSSG) [µmol/g]     control and  acetaminophen       • control  ...... 5.86 (N=2)         • post-Rx 300 mg/kg  ...... 1.84 (N=4)           • comparison   37 strains   age 8-17wks   Inbred Threadgill1 ratio of reduced (GSH) to oxidized (GSSG) glutathione [ratio]     control and  acetaminophen       • control  ...... 21.9 (N=2)         • post-Rx 300mg/kg  ...... 15.5 (N=4)           • comparison   35 strains   age 8-17wks   Inbred   liver — weight         scales   Threadgill1 liver weight [g]     control and  acetaminophen       • control  ...... 1.04 (N=4)         24h post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 0.905 (N=4)                 • comparison   37 strains   age 8-17wks   Inbred

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