Home       About             Help       Phenotype data > MSM/Ms strain > interventions > acetaminophen (pain reliever e.g. Tylenol)   See also:   Wikipedia Measurements: About these MSM/Ms averages (♀ ♂) Exit MSM/Ms mode blood — clinical chemistry — enzymes — ALT         metabolic panel   Threadgill1 alanine aminotransferase (serum ALT) [IU/L]     control and  acetaminophen       100 mg/kg:             • control  ...... 58.0 (N=2)               • 4h  ......             • 12h  ......             • 24h  ......               • time comparison   37 strains   age 8-17wks   Inbred   blood — clinical chemistry — enzymes — AST         metabolic panel   Threadgill1 aspartate aminotransferase (serum AST) [IU/L]     control and  acetaminophen       • control  ...... 117 (N=2)         post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 2560 (N=3)                 • comparison   37 strains   age 8-17wks   Inbred   blood — clinical chemistry — urea nitrogen         metabolic panel   Threadgill1 blood urea nitrogen (BUN) [mg/dL]     control and  acetaminophen       • control  ...... 13.0 (N=2) ▼         post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 21.0 (N=2)                 • comparison   36 strains   age 8-17wks   Inbred   liver — enzyme homeostasis         ELISA   Threadgill1 cytochrome P450 1A2 isoform [pmol/mg]     control and  acetaminophen 300 mg/kg       • control  ...... 263 (N=2) ▲         • post-Rx 300 mg/kg  ...... 221 (N=3) ▲           • comparison   36 strains   age 8-12wks   Inbred Threadgill1 cytochrome P450 2E1 isoform [pmol/mg]     control and  acetaminophen 300 mg/kg       • control  ...... 162 (N=2) ▲         • post-Rx 300 mg/kg  ...... 137 (N=3) ▲▲           • comparison   36 strains   age 8-12wks   Inbred   liver — enzyme homeostasis         HPLC   Threadgill1 glutathione transferase [µg/mL]     control and  acetaminophen 300 mg/kg       • control  ...... 1787 (N=2) ▲▲         • post-Rx 300 mg/kg  ...... 1529 (N=3) ▲▲         36 strains   age 8-12wks   Inbred   liver — enzyme homeostasis         metabolic panel   Threadgill1 catalase [µg/mL]     control and  acetaminophen 300 mg/kg       • control  ...... 590 (N=2)         • post-Rx 300 mg/kg  ...... 599 (N=3) ▲           • comparison   36 strains   age 8-12wks   Inbred   liver — pathology         histopathology   Threadgill1 necrosis [%]     control and  acetaminophen       • control  ...... 0 (N=2)         post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 47.0 (N=3) ▲                 • comparison   37 strains   age 8-17wks   Inbred   liver — protein homeostasis — glutathione         HPLC   Threadgill1 reduced glutathione (GSH) [µmol/g]     control and  acetaminophen       • control  ...... 4.95 (N=2)         • post-Rx 300mg/kg  ...... 4.04 (N=4) ▲           • comparison   35 strains   age 8-17wks   Inbred Threadgill1 oxidized glutathione (GSSG) [µmol/g]     control and  acetaminophen       • control  ...... 0.422 (N=2) ▲         • post-Rx 300mg/kg  ...... 0.383 (N=4) ▲▲           • comparison   35 strains   age 8-17wks   Inbred Threadgill1 total glutathione (GSH plus GSSG) [µmol/g]     control and  acetaminophen       • control  ...... 5.79 (N=2)         • post-Rx 300 mg/kg  ...... 4.80 (N=4) ▲           • comparison   37 strains   age 8-17wks   Inbred Threadgill1 ratio of reduced (GSH) to oxidized (GSSG) glutathione [ratio]     control and  acetaminophen       • control  ...... 11.8 (N=2)         • post-Rx 300mg/kg  ...... 10.3 (N=4)           • comparison   35 strains   age 8-17wks   Inbred   liver — weight         scales   Threadgill1 liver weight [g]     control and  acetaminophen       • control  ...... 0.550 (N=4) ▼         24h post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 0.767 (N=3) ▼                 • comparison   37 strains   age 8-17wks   Inbred

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