|
body weight
scales
|
|
|
|
fold change in body weight over testing period
[ratio]
| control and
|
DB289
|
|
......
0.814
......
0.840
......
1.03
|
Inbred
|
| |
|
brain — morphology — size
histopathology
|
|
|
......
4.08
4.11
......
1.06
1.09
......
1.11
1.13
|
Inbred
|
|
|
......
1.63
1.66
......
0.303
0.317
......
0.929
0.947
|
Inbred
|
|
|
......
0.465
0.459
......
0.123
0.134
......
0.926
0.989
|
Inbred
|
| |
|
brain — morphology — weight
scales
|
|
|
......
0.424
0.444
......
0.431
0.424
|
ages shown
Inbred
|
|
|
|
brain weight as percent of body weight
[%]
|
|
......
2.09
1.85
......
1.85
1.47
|
ages shown
Inbred
|
|
|
|
brain weight (after fixation and trimming)
|
|
......
0.486
0.494
......
2.37
1.79
|
Inbred
|
| |
|
cardiovascular — heart weight
scales
|
|
|
weight:
......
78.4
98.4
......
62.3
75.2
......
16.1
23.2
normalized:
......
3.85
3.86
......
3.06
2.95
......
0.789
0.911
|
Inbred
|
|
|
weight:
......
4.90
9.49
......
2.41
4.40
......
2.49
5.18
normalized:
......
0.242
0.369
......
0.119
0.171
......
0.122
0.202
|
Inbred
|
|
|
......
0.0949
0.145
......
0.106
0.147
|
ages shown
Inbred
|
|
|
|
heart weight as percent of body weight
[%]
|
|
......
0.466
0.600
......
0.454
0.508
|
ages shown
Inbred
|
|
|
weight:
......
108
......
104
......
120
......
130
normalized:
......
4.10
......
4.05
......
4.36
......
4.69
|
Inbred
|
|
|
weight:
......
7.01
......
7.24
......
9.14
......
10.2
normalized:
......
0.267
......
0.283
......
0.333
......
0.369
|
Inbred
|
|
|
weight:
......
101
......
96.4
......
110
......
120
normalized:
......
3.84
......
3.77
......
4.02
......
4.33
|
Inbred
|
|
|
......
14.6
......
13.4
......
12.2
......
11.9
|
Inbred
|
|
|
......
0.135
......
0.468
|
Inbred
|
| |
|
endocrine — adrenal — morphology — weight
scales
|
|
|
weight:
......
8.34
4.10
......
4.52
2.21
......
3.82
1.89
normalized:
......
0.410
0.162
......
0.222
0.0872
......
0.188
0.0744
|
Inbred
|
| |
|
immune system — morphology — thymus
scales
|
|
|
......
39.2
39.6
......
1.94
1.56
|
Inbred
|
| |
|
kidney — morphology — area
metric
|
|
|
|
kidney planar surface area
[mm2]
|
|
......
5.05
5.22
......
4.42
4.57
|
Inbred
|
|
|
|
normalized kidney planar surface area
[mm2/g]
|
|
......
3.75
3.63
......
3.28
3.18
|
Inbred
|
| |
|
kidney — morphology — weight
scales
|
|
|
weight:
......
258
405
......
130
197
......
128
208
normalized:
......
10.2
15.9
......
5.11
7.73
......
5.05
8.18
|
Inbred
|
|
|
......
0.00641
0.00642
......
0.00665
0.00694
......
0.0131
0.0134
|
Inbred
|
|
|
|
percent kidney weight to body weight
[%]
|
|
......
0.473
0.443
......
0.487
0.479
......
0.961
0.922
|
Inbred
|
|
|
|
kidney (left) weight
[g]
| control and
|
DB289
|
|
......
0.128
......
0.134
|
Inbred
|
|
|
|
kidney (right) weight
[g]
| control and
|
DB289
|
|
......
0.140
......
0.138
|
Inbred
|
|
|
|
kidney (both) weight
[g]
| control and
|
DB289
|
|
......
0.268
......
0.272
|
Inbred
|
|
|
|
total kidney weight as percent of body weight
[%]
| control and
|
DB289
|
|
......
1.51
......
1.46
......
0.967
|
Inbred
|
|
|
......
0.131
0.200
......
0.141
0.249
|
ages shown
Inbred
|
|
|
|
kidney (right) weight
[g]
|
|
......
0.136
0.192
......
0.144
0.239
|
ages shown
Inbred
|
|
|
|
kidney (left) weight, as percent of body weight
[%]
|
|
......
0.644
0.830
......
0.604
0.860
|
ages shown
Inbred
|
|
|
|
kidney (right) weight, as percent of body weight
[%]
|
|
......
0.666
0.798
......
0.616
0.826
|
ages shown
Inbred
|
|
|
......
0.493
......
1.71
|
Inbred
|
| |
|
liver — weight
scales
|
|
|
|
liver weight at sacrifice
[g]
| control and
|
DB289
|
|
......
0.820
......
0.766
|
Inbred
|
|
|
|
liver weight as percent of body weight
[%]
| control and
|
DB289
|
|
......
4.59
......
4.13
......
0.900
|
Inbred
|
|
|
......
1.04
1.27
......
1.21
1.40
|
ages shown
Inbred
|
|
|
|
liver weight as percent of body weight
[%]
|
|
......
5.12
5.23
......
5.20
4.86
|
ages shown
Inbred
|
|
|
|
Inbred
|
|
|
|
liver weight as a percent of body weight
[%]
|
high-fat diet, ethanol
|
|
......
6.72
(N=3)
......
8.19
(N=3)
|
Inbred
|
|
|
......
1.26
(N=4)
24h post-Rx mg/kg:
......
......
......
1.44
(N=4)
|
Inbred
|
| |
|
local experiment parameter
|
|
|
|
Inbred
|
| |
|
reproduction — morphology — male
scales
|
|
|
|
Inbred
|
|
|
|
Inbred
|
| |
|
spleen — weight
scales
|
|
|
......
0.101
0.0885
......
0.110
0.111
|
ages shown
Inbred
|
|
|
|
spleen weight, as percent of body weight
[%]
|
|
......
0.496
0.366
......
0.474
0.380
|
ages shown
Inbred
|