body weight         scales   Harrill2 fold change in body weight over testing period [ratio]     control and  DB289       • control  ...... 0.938         • DB289  ...... 0.870         • difference  ...... 0.928         34 strains   age 6-8wks   Inbred   brain — morphology — size         histopathology   Wahlsten1 corpus callosum         • length at mid-sagittal plane  ...... 3.58   3.55         • cross-sectional area at midplane  ...... 0.722   0.669         • index  ...... 0.890   0.877         21 strains   age 12wks   Inbred Wahlsten1 hippocampus         • length at mid-sagittal plane  ...... 1.28   1.27         • cross-sectional area at midplane  ...... 0.224   0.216 ▼         • index  ...... 0.808   0.839         21 strains   age 12wks   Inbred Wahlsten1 anterior commissure         • length at mid-sagittal plane  ...... 0.408   0.398 ▼         • cross-sectional area at midplane  ...... 0.105   0.101         • index  ...... 0.907   0.920         21 strains   age 12wks   Inbred   brain — morphology — weight         scales   Jaxpheno2 brain weight [g]         • age 8wks  ...... 0.354 ▼   0.349 ▼▼         • age 16wks  ...... 0.384 ▼   0.357 ▼           • age comparison   11 strains   ages shown   Inbred Jaxpheno2 brain weight as percent of body weight [%]         • age 8wks  ...... 1.95   1.54 ▼         • age 16wks  ...... 1.42 ▼   1.23 ▼           • age comparison   11 strains   ages shown   Inbred Wahlsten1 brain weight (after fixation and trimming)         • weight  ...... 0.432   0.413         • as percent of body weight  ...... 2.15   1.72         21 strains   age 12wks   Inbred   cardiovascular — aorta and ventricle dimensions         echocardiography   Jaxpheno8 intra-ventricular septum thickness [mm]         • diastolic  ...... 0.716         • systolic  ...... 0.972           • comparison   6 strains   age 12wks   Inbred Jaxpheno8 left ventricle anterior wall thickness [mm]         • diastolic  ...... 0.750         • systolic  ...... 1.23           • comparison   6 strains   age 12wks   Inbred Jaxpheno8 left ventricle posterior wall thickness [mm]         • diastolic  ...... 0.784 ▲         • systolic  ...... 1.06           • comparison   6 strains   age 12wks   Inbred Jaxpheno8 left ventricle internal dimension [mm]         • diastolic  ...... 3.93         • systolic  ...... 2.30           • comparison   6 strains   age 12wks   Inbred Jaxpheno8 left ventricle volume [µL]         • diastolic  ...... 67.1         • systolic  ...... 19.1           • comparison   6 strains   age 12wks   Inbred   cardiovascular — heart weight         scales   Deschepper1 ventricle weight [mg]         weight:             • both  ...... 97.1   119 ▲               • left  ...... 74.3   88.7               • right  ...... 26.1 ▲   30.5 ▲         normalized:             • both  ...... 5.18 ▲   5.10 ▲               • left  ...... 3.94   3.79               • right  ...... 1.39 ▲   1.31 ▲               13 strains   age 10wks   Inbred Deschepper1 atria weight [mg]         weight:             • both  ...... 5.60   6.63               • left  ...... 2.11   3.21               • right  ...... 3.49   3.42         normalized:             • both  ...... 0.298   0.284               • left  ...... 0.112   0.137               • right  ...... 0.186   0.147               13 strains   age 10wks   Inbred Jaxpheno2 heart weight [g]         • age 8wks  ...... 0.117   0.186 ▲         • age 16wks  ...... 0.134   0.179           • age comparison   11 strains   ages shown   Inbred Jaxpheno2 heart weight as percent of body weight [%]         • age 8wks  ...... 0.643   0.853 ▲▲         • age 16wks  ...... 0.496   0.614 ▲           • age comparison   11 strains   ages shown   Inbred Maurer1 heart weight [mg]     control and  atenolol, isoproterenol 2wks       weight:             • control  ...... 118               • atenolol 10mg  ...... 110               • isoprot 1mg  ...... 111               • isoprot 10mg  ...... 131                 • comparison         normalized:             • control  ...... 5.01 ▲               • atenolol 10mg  ...... 4.87 ▲               • isoprot 1mg  ...... 4.88               • isoprot 10mg  ...... 5.80 ▲                 • comparison   23 strains   age 7-13wks   Inbred Maurer1 atria weight [mg]     control and  atenolol, isoproterenol 2wks       weight:             • control  ...... 6.68               • atenolol 10mg  ...... 6.25               • isoprot 1mg  ...... 6.76               • isoprot 10mg  ...... 8.21                 • comparison         normalized:             • control  ...... 0.284 ▲               • atenolol 10mg  ...... 0.276               • isoprot 1mg  ...... 0.296               • isoprot 10mg  ...... 0.362 ▲                 • comparison   23 strains   age 7-13wks   Inbred Maurer1 ventricle (both) weight [mg]     control and  atenolol, isoproterenol 2wks       weight:             • control  ...... 111               • atenolol 10mg  ...... 104               • isoprot 1mg  ...... 105               • isoprot 10mg  ...... 123                 • comparison         normalized:             • control  ...... 4.73 ▲               • atenolol 10mg  ...... 4.59 ▲               • isoprot 1mg  ...... 4.58               • isoprot 10mg  ...... 5.44 ▲                 • comparison   23 strains   age 7-13wks   Inbred Maurer1 atria weight to ventricle weight ratio [ratio]     control and  atenolol, isoproterenol 2wks       • control  ...... 16.8         • atenolol 10mg  ...... 16.8         • isoprot 1mg  ...... 15.5         • isoprot 10mg  ...... 15.1           • comparison   23 strains   age 7-13wks   Inbred Reed1 heart weight         • weight [g]  ...... 0.189 ▲         • as percent of body weight [%]  ...... 0.674 ▲▲         28 strains   age 29-67wks   Inbred   endocrine — adrenal — morphology — size         histopathology   DiCurzio1 adrenal width [µm]         • whole gland  ...... 1186   906 ▼▼         • medulla  ...... 524   434 ▼           • comparison   65 strains   age 7-10wks*   BXD DiCurzio1 adrenal cortex zones [µm]         • zona glomerulosa  ...... 38.1 ▼   45.6         • zona intermedia  ...... 13.5   14.6         • zona fasciculata  ...... 115 ▼   111         • zona reticularis  ...... 70.5   44.9 ▼         • X-zone  ...... 47.1   0           • comparison   65 strains   age 7-10wks*   BXD   endocrine — adrenal — morphology — weight         scales   Deschepper1 adrenal weight [mg]         weight:             • both  ...... 4.59   3.89               • left  ...... 2.28 ▼   2.21               • right  ...... 2.31   1.68         normalized:             • both  ...... 0.246 ▼   0.168               • left  ...... 0.122 ▼   0.0965               • right  ...... 0.124 ▼   0.0715               13 strains   age 10wks   Inbred DiCurzio1 adrenal weights [mg]         • left  ...... 2.32   1.90         • right  ...... 2.28   1.92         • average  ...... 2.30   1.91         • adjusted to bw  ...... 0.235   0.166           • comparison   66 strains   age 7-10wks*   BXD   eye — morphology         metric   Chang1 eye diameter   [mm] ...... 3.24   17 strains   age >7wks   Inbred   immune system — morphology — thymus         scales   Deschepper1 thymus weight [mg]         • weight  ...... 33.4   52.8         • normalized  ...... 1.78   2.23         13 strains   age 10wks   Inbred   kidney — morphology — area         metric   Gupta1 kidney planar surface area [mm2]         • left  ...... 5.40   5.18 (N=2)         • right  ...... 4.56   5.12 (N=2)           • comparison   8 strains   age postnatal d1   Inbred Gupta1 normalized kidney planar surface area [mm2/g]         • left  ...... 4.41 ▲   3.88 (N=2)         • right  ...... 3.71   3.84 (N=2)           • comparison   7 strains   age postnatal d1   Inbred   kidney — morphology — weight         scales   Deschepper1 kidney weight [mg]         weight:             • both  ...... 258   349               • left  ...... 131   175               • right  ...... 127   174         normalized:             • both  ...... 13.8   14.9               • left  ...... 7.01   7.45               • right  ...... 6.76   7.44               13 strains   age 10wks   Inbred Gupta1 kidney weight [g]         • left  ...... 0.00642   0.00715 (N=2)         • right  ...... 0.00602 ▼   0.00720 (N=2)         • both  ...... 0.0124 ▼   0.0143 (N=2)           • comparison   7 strains   age postnatal d1   Inbred Gupta1 percent kidney weight to body weight [%]         • left  ...... 0.522 ▲   0.536 (N=2) ▲         • right  ...... 0.491   0.538 (N=2)         • both  ...... 1.01   1.07 (N=2) ▲           • comparison   7 strains   age postnatal d1   Inbred Harrill2 kidney (left) weight [g]     control and  DB289       • control  ...... 0.132         • DB289  ...... 0.116           • comparison   34 strains   age 6-8wks   Inbred Harrill2 kidney (right) weight [g]     control and  DB289       • control  ...... 0.126         • DB289  ...... 0.116           • comparison   34 strains   age 6-8wks   Inbred Harrill2 kidney (both) weight [g]     control and  DB289       • control  ...... 0.254         • DB289  ...... 0.236           • comparison   34 strains   age 6-8wks   Inbred Harrill2 total kidney weight as percent of body weight [%]     control and  DB289       • control  ...... 1.38         • DB289  ...... 1.39         • difference  ...... 1.01         34 strains   age 6-8wks   Inbred Jaxpheno2 kidney (left) weight [g]         • age 8wks  ...... 0.102 ▼   0.167         • age 16wks  ...... 0.169 ▲   0.253           • age comparison   11 strains   ages shown   Inbred Jaxpheno2 kidney (right) weight [g]         • age 8wks  ...... 0.110 ▼   0.164         • age 16wks  ...... 0.170 ▲   0.256           • age comparison   11 strains   ages shown   Inbred Jaxpheno2 kidney (left) weight, as percent of body weight [%]         • age 8wks  ...... 0.565   0.731         • age 16wks  ...... 0.628   0.870           • age comparison   11 strains   ages shown   Inbred Jaxpheno2 kidney (right) weight, as percent of body weight [%]         • age 8wks  ...... 0.603   0.718         • age 16wks  ...... 0.630   0.880           • age comparison   11 strains   ages shown   Inbred Reed1 kidney weight         • weight [g]  ...... 0.665         • as percent of body weight [%]  ...... 2.36 ▲         28 strains   age 29-67wks   Inbred   liver — weight         scales   Harrill2 liver weight at sacrifice [g]     control and  DB289       • control  ...... 0.746         • DB289  ...... 0.630           • comparison   34 strains   age 6-8wks   Inbred Harrill2 liver weight as percent of body weight [%]     control and  DB289       • control  ...... 4.07         • DB289  ...... 3.71         • difference  ...... 0.912         34 strains   age 6-8wks   Inbred Jaxpheno2 liver weight [g]         • age 8wks  ...... 0.903   1.13 ▼         • age 16wks  ...... 1.36   1.33           • age comparison   11 strains   ages shown   Inbred Jaxpheno2 liver weight as percent of body weight [%]         • age 8wks  ...... 4.97   4.97 ▼         • age 16wks  ...... 5.03   4.56           • age comparison   11 strains   ages shown   Inbred Paigen1 liver weight at sacrifice   [g] ...... 1.68   2.03     high-fat diet   8wks 43 strains   age 15-19wks   Inbred Rusyn5 liver weight as a percent of body weight [%]   high-fat diet, ethanol       • high-fat only  ...... 6.79 (N=3)         • high-fat and ethanol  ...... 6.78 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Threadgill1 liver weight [g]     control and  acetaminophen       • control  ...... 1.11 (N=4)         24h post-Rx mg/kg:             • 100  ...... 1.15 (N=4)               • 200  ...... 1.12 (N=4)               • 300  ...... 1.26                 • comparison   37 strains   age 8-17wks   Inbred   local experiment parameter   Rusyn2 liver weight as percent of body weight, naive   [ratio] ...... 4.60 (N=3)   17 strains   age 7wks   Inbred   reproduction — morphology — male         scales   Handel1 seminal vesicle weight (both left and right)   [g] ...... 0.268 ▲   14 strains   age 8-10wks   Inbred Handel1 testicular weight (both left and right)   [g] ...... 0.169   14 strains   age 8-10wks   Inbred   spleen — weight         scales   Jaxpheno2 spleen weight [g]         • age 8wks  ...... 0.0722   0.0839         • age 16wks  ...... 0.109 ▲   0.0817           • age comparison   11 strains   ages shown   Inbred Jaxpheno2 spleen weight, as percent of body weight [%]         • age 8wks  ...... 0.394   0.370 ▲         • age 16wks  ...... 0.400   0.282           • age comparison   11 strains   ages shown   Inbred

152 measurements listed.