body weight         scales   Harrill2 fold change in body weight over testing period [ratio]     control and  DB289       • control  ...... 0.878         • DB289  ...... 0.808         • difference  ...... 0.920         34 strains   age 6-8wks   Inbred   brain — morphology — size         histopathology   Wahlsten1 corpus callosum         • length at mid-sagittal plane  ...... 3.81   3.57         • cross-sectional area at midplane  ...... 0.911   0.823         • index  ...... 1.05   0.928         21 strains   age 12wks   Inbred Wahlsten1 hippocampus         • length at mid-sagittal plane  ...... 1.72   1.63         • cross-sectional area at midplane  ...... 0.366 ▲   0.350         • index  ...... 1.24 ▲   1.15 ▲         21 strains   age 12wks   Inbred Wahlsten1 anterior commissure         • length at mid-sagittal plane  ...... 0.417   0.417         • cross-sectional area at midplane  ...... 0.122   0.115         • index  ...... 0.994   0.921         21 strains   age 12wks   Inbred   brain — morphology — weight         scales   Jaxpheno2 brain weight [g]         • age 8wks  ...... 0.425   0.422         • age 16wks  ...... 0.381 ▼   0.382           • age comparison   11 strains   ages shown   Inbred Jaxpheno2 brain weight as percent of body weight [%]         • age 8wks  ...... 2.20   1.72         • age 16wks  ...... 1.86   1.50           • age comparison   11 strains   ages shown   Inbred Wahlsten1 brain weight (after fixation and trimming)         • weight  ...... 0.455   0.461         • as percent of body weight  ...... 2.32   1.91         21 strains   age 12wks   Inbred   cardiovascular — aorta and ventricle dimensions         echocardiography   Jaxpheno8 intra-ventricular septum thickness [mm]         • diastolic  ...... 0.637 (N=4) ▼         • systolic  ...... 1.04 (N=4)           • comparison   6 strains   age 12wks   Inbred Jaxpheno8 left ventricle anterior wall thickness [mm]         • diastolic  ...... 0.676         • systolic  ...... 0.992           • comparison   6 strains   age 12wks   Inbred Jaxpheno8 left ventricle posterior wall thickness [mm]         • diastolic  ...... 0.606 ▼         • systolic  ...... 0.934 ▼           • comparison   6 strains   age 12wks   Inbred Jaxpheno8 left ventricle internal dimension [mm]         • diastolic  ...... 4.03         • systolic  ...... 2.78           • comparison   6 strains   age 12wks   Inbred Jaxpheno8 left ventricle volume [µL]         • diastolic  ...... 71.9         • systolic  ...... 29.4           • comparison   6 strains   age 12wks   Inbred   cardiovascular — heart weight         scales   Deschepper1 ventricle weight [mg]         weight:             • both  ...... 77.1   89.7               • left  ...... 61.3   68.4               • right  ...... 16.2   21.3         normalized:             • both  ...... 3.99   3.68 ▼               • left  ...... 3.18   2.80 ▼               • right  ...... 0.849   0.875               13 strains   age 10wks   Inbred Deschepper1 atria weight [mg]         weight:             • both  ...... 5.36   6.22               • left  ...... 2.15   2.66               • right  ...... 3.21   3.56         normalized:             • both  ...... 0.280   0.258               • left  ...... 0.112   0.110               • right  ...... 0.168   0.148               13 strains   age 10wks   Inbred Jaxpheno2 heart weight [g]         • age 8wks  ...... 0.0953   0.111 ▼         • age 16wks  ...... 0.0904 ▼   0.120 ▼           • age comparison   11 strains   ages shown   Inbred Jaxpheno2 heart weight as percent of body weight [%]         • age 8wks  ...... 0.496   0.452 ▼         • age 16wks  ...... 0.442   0.462           • age comparison   11 strains   ages shown   Inbred Maurer1 heart weight [mg]     control and  atenolol, isoproterenol       weight:             • control  ...... 91.7               • atenolol 10mg  ...... 92.8               • isoprot 1mg  ...... 95.3               • isoprot 10mg  ...... 111                 • comparison         normalized:             • control  ...... 3.68 ▼               • atenolol 10mg  ...... 3.58 ▼               • isoprot 1mg  ...... 3.76 ▼               • isoprot 10mg  ...... 4.18 ▼                 • comparison   23 strains   age 7-13wks   Inbred Maurer1 atria weight [mg]     control and  atenolol, isoproterenol       weight:             • control  ...... 5.35               • atenolol 10mg  ...... 5.92               • isoprot 1mg  ...... 6.39               • isoprot 10mg  ...... 7.59                 • comparison         normalized:             • control  ...... 0.215               • atenolol 10mg  ...... 0.227               • isoprot 1mg  ...... 0.253               • isoprot 10mg  ...... 0.288                 • comparison   23 strains   age 7-13wks   Inbred Maurer1 ventricle (both) weight [mg]     control and  atenolol, isoproterenol       weight:             • control  ...... 86.3               • atenolol 10mg  ...... 86.8               • isoprot 1mg  ...... 88.9               • isoprot 10mg  ...... 103                 • comparison         normalized:             • control  ...... 3.46 ▼               • atenolol 10mg  ...... 3.35 ▼               • isoprot 1mg  ...... 3.51 ▼               • isoprot 10mg  ...... 3.90 ▼                 • comparison   23 strains   age 7-13wks   Inbred Maurer1 atria weight to ventricle weight ratio [ratio]     control and  atenolol, isoproterenol       • control  ...... 16.5         • atenolol 10mg  ...... 14.8         • isoprot 1mg  ...... 14.1         • isoprot 10mg  ...... 13.7           • comparison   23 strains   age 7-13wks   Inbred Reed1 heart weight         • weight [g]  ...... 0.118 ▼         • as percent of body weight [%]  ...... 0.439 ▼         28 strains   age 29-67wks   Inbred   endocrine — adrenal — morphology — weight         scales   Deschepper1 adrenal weight [mg]         weight:             • both  ...... 6.85   3.17               • left  ...... 3.58   1.59 ▼               • right  ...... 3.58   1.59         normalized:             • both  ...... 0.356   0.133 ▼               • left  ...... 0.185   0.0661 ▼               • right  ...... 0.186   0.0658               13 strains   age 10wks   Inbred   immune system — morphology — thymus         scales   Deschepper1 thymus weight [mg]         • weight  ...... 52.2   58.7 ▲         • normalized  ...... 2.70   2.39 ▲         13 strains   age 10wks   Inbred   kidney — morphology — area         metric   Gupta1 kidney planar surface area [mm2]         • left  ...... 4.26 ▼▼         • right  ...... 3.98 ▼           • comparison   8 strains   age postnatal d1   Inbred Gupta1 normalized kidney planar surface area [mm2/g]         • left  ......       • right  ......         • comparison   7 strains   age postnatal d1   Inbred   kidney — morphology — weight         scales   Deschepper1 kidney weight [mg]         weight:             • both  ...... 276   460 ▲               • left  ...... 132   221 ▲               • right  ...... 144   239 ▲         normalized:             • both  ...... 14.3   18.8 ▲               • left  ...... 6.84   9.05 ▲               • right  ...... 7.45   9.75 ▲               13 strains   age 10wks   Inbred Gupta1 kidney weight [g]         • left  ......       • right  ......       • both  ......         • comparison   7 strains   age postnatal d1   Inbred Gupta1 percent kidney weight to body weight [%]         • left  ......       • right  ......       • both  ......         • comparison   7 strains   age postnatal d1   Inbred Harrill2 kidney (left) weight [g]     control and  DB289       • control  ...... 0.132         • DB289  ...... 0.102           • comparison   34 strains   age 6-8wks   Inbred Harrill2 kidney (right) weight [g]     control and  DB289       • control  ...... 0.140         • DB289  ...... 0.112           • comparison   34 strains   age 6-8wks   Inbred Harrill2 kidney (both) weight [g]     control and  DB289       • control  ...... 0.272         • DB289  ...... 0.214           • comparison   34 strains   age 6-8wks   Inbred Harrill2 total kidney weight as percent of body weight [%]     control and  DB289       • control  ...... 1.59         • DB289  ...... 1.36         • difference  ...... 0.855 ▼         34 strains   age 6-8wks   Inbred Jaxpheno2 kidney (left) weight [g]         • age 8wks  ...... 0.112   0.188         • age 16wks  ...... 0.122   0.206           • age comparison   11 strains   ages shown   Inbred Jaxpheno2 kidney (right) weight [g]         • age 8wks  ...... 0.127   0.210 ▲         • age 16wks  ...... 0.135   0.233           • age comparison   11 strains   ages shown   Inbred Jaxpheno2 kidney (left) weight, as percent of body weight [%]         • age 8wks  ...... 0.576   0.764         • age 16wks  ...... 0.600   0.788           • age comparison   11 strains   ages shown   Inbred Jaxpheno2 kidney (right) weight, as percent of body weight [%]         • age 8wks  ...... 0.654   0.850 ▲         • age 16wks  ...... 0.656   0.890           • age comparison   11 strains   ages shown   Inbred Reed1 kidney weight         • weight [g]  ...... 0.523         • as percent of body weight [%]  ...... 1.95         28 strains   age 29-67wks   Inbred   liver — weight         scales   Harrill2 liver weight at sacrifice [g]     control and  DB289       • control  ...... 0.776         • DB289  ...... 0.634           • comparison   34 strains   age 6-8wks   Inbred Harrill2 liver weight as percent of body weight [%]     control and  DB289       • control  ...... 4.56 ▲         • DB289  ...... 4.05         • difference  ...... 0.888         34 strains   age 6-8wks   Inbred Jaxpheno2 liver weight [g]         • age 8wks  ...... 1.07   1.31         • age 16wks  ...... 0.823 ▼▼   1.28 ▼           • age comparison   11 strains   ages shown   Inbred Jaxpheno2 liver weight as percent of body weight [%]         • age 8wks  ...... 5.51   5.27         • age 16wks  ...... 3.97 ▼   4.96           • age comparison   11 strains   ages shown   Inbred Paigen1 liver weight at sacrifice   [g] ...... 1.65   1.85     high-fat diet 8wks 43 strains   age 15-19wks   Inbred Rusyn5 liver weight as a percent of body weight [%]   high-fat diet , ethanol       • high-fat only  ...... 5.43 (N=3) ▼         • high-fat and ethanol  ...... 6.69 (N=3)           • comparison   14 strains   age 8-14wks   Inbred Threadgill1 liver weight [g]     control and  acetaminophen       • control  ...... 1.20 (N=4)         24h post-Rx mg/kg:             • 100  ...... 1.33 (N=4)               • 200  ...... 1.33 (N=3)               • 300  ...... 1.30 (N=4)                 • comparison   37 strains   age 8-17wks   Inbred   local experiment parameter   Rusyn2 liver weight as percent of body weight, naive   [ratio] ...... 5.00   17 strains   age 7wks   Inbred   reproduction — morphology — male         scales   Handel1 seminal vesicle weight (both left and right)   [g] ...... 0.201   14 strains   age 8-10wks   Inbred Handel1 testicular weight (both left and right)   [g] ...... 0.158   14 strains   age 8-10wks   Inbred   spleen — weight         scales   Jaxpheno2 spleen weight [g]         • age 8wks  ...... 0.0967   0.0738         • age 16wks  ...... 0.0928   0.0773           • age comparison   11 strains   ages shown   Inbred Jaxpheno2 spleen weight, as percent of body weight [%]         • age 8wks  ...... 0.496   0.298         • age 16wks  ...... 0.454   0.300           • age comparison   11 strains   ages shown   Inbred

140 measurements listed.