|
body weight
scales
|
|
|
fold change in body weight over testing period
[ratio]
control and
DB289
......
0.888
......
0.690
......
0.777
|
Inbred
|
| |
|
brain — morphology — size
histopathology
|
|
|
corpus callosum
......
3.77
3.69
......
0.926
0.921
......
0.960
0.993
|
Inbred
|
|
|
hippocampus
......
1.53
1.47
......
0.303
0.288
......
0.911
0.903
|
Inbred
|
|
|
anterior commissure
......
0.459
0.446
......
0.122
0.120
......
0.905
0.923
|
Inbred
|
| |
|
brain — morphology — weight
scales
|
|
|
brain weight (after fixation and trimming)
......
0.491
0.477
......
1.97
1.70
|
Inbred
|
| |
|
cardiovascular — aorta and ventricle dimensions
echocardiography
|
|
|
intra-ventricular septum thickness
[mm]
......
0.817
......
1.18
|
Inbred
|
|
|
left ventricle anterior wall thickness
[mm]
......
0.853
......
1.25
|
Inbred
|
|
|
left ventricle posterior wall thickness
[mm]
......
0.760
......
1.06
|
Inbred
|
|
|
left ventricle internal dimension
[mm]
......
3.92
......
2.51
|
Inbred
|
|
|
left ventricle volume
[µL]
......
66.8
......
22.8
|
Inbred
|
| |
|
cardiovascular — heart weight
scales
|
|
|
ventricle weight
[mg]
weight:
......
112
130
......
86.4
97.7
......
27.9
32.4
normalized:
......
4.27
4.71
......
3.30
3.54
......
1.07
1.17
|
Inbred
|
|
|
atria weight
[mg]
weight:
......
6.09
4.80
......
2.52
2.39
......
3.57
2.36
normalized:
......
0.228
0.172
......
0.0939
0.0858
......
0.134
0.0854
|
Inbred
|
|
|
heart weight
[mg]
control and
atenolol, isoproterenol
weight:
......
125
......
120
......
129
......
133
normalized:
......
4.56
......
4.27
......
4.45
......
4.76
|
Inbred
|
|
|
atria weight
[mg]
control and
atenolol, isoproterenol
weight:
......
5.58
......
5.56
......
6.79
......
7.64
normalized:
......
0.203
......
0.198
......
0.233
......
0.272
|
Inbred
|
|
|
ventricle (both) weight
[mg]
control and
atenolol, isoproterenol
weight:
......
120
......
114
......
122
......
125
normalized:
......
4.36
......
4.07
......
4.22
......
4.48
|
Inbred
|
|
|
atria weight to ventricle weight ratio
[ratio]
control and
atenolol, isoproterenol
......
21.5
......
20.7
......
18.2
......
16.7
|
Inbred
|
|
|
heart weight
......
0.173
......
0.503
|
Inbred
|
| |
|
endocrine — adrenal — morphology — weight
scales
|
|
|
adrenal weight
[mg]
weight:
......
6.63
3.62
......
3.29
1.93
......
3.33
1.69
normalized:
......
0.242
0.132
......
0.121
0.0702
......
0.125
0.0615
|
Inbred
|
| |
|
immune system — morphology — thymus
scales
|
|
|
thymus weight
[mg]
......
117
66.0
......
4.42
2.39
|
Inbred
|
| |
|
kidney — morphology — area
metric
|
|
|
kidney planar surface area
[mm2]
......
5.03
(N=4)
5.76
......
4.48
(N=4)
5.17
|
Inbred
|
|
|
normalized kidney planar surface area
[mm2/g]
......
3.77
(N=4)
3.97
......
3.35
(N=4)
3.57
|
Inbred
|
| |
|
kidney — morphology — weight
scales
|
|
|
kidney weight
[mg]
weight:
......
309
399
......
150
193
......
159
206
normalized:
......
11.7
14.5
......
5.73
7.01
......
6.01
7.48
|
Inbred
|
|
|
kidney weight
[g]
......
0.00690
(N=4)
0.00730
......
0.00705
(N=4)
0.00785
......
0.0140
(N=4)
0.0151
|
Inbred
|
|
|
percent kidney weight to body weight
[%]
......
0.514
(N=4)
0.502
......
0.523
(N=4)
0.540
......
1.04
(N=4)
1.04
|
Inbred
|
|
|
kidney (left) weight
[g]
control and
DB289
......
0.138
......
0.114
|
Inbred
|
|
|
kidney (right) weight
[g]
control and
DB289
......
0.148
......
0.120
|
Inbred
|
|
|
kidney (both) weight
[g]
control and
DB289
......
0.288
......
0.234
|
Inbred
|
|
|
total kidney weight as percent of body weight
[%]
control and
DB289
......
1.38
......
1.48
......
1.07
|
Inbred
|
|
|
kidney weight
......
0.562
......
1.63
|
Inbred
|
| |
|
liver — weight
scales
|
|
|
liver weight at sacrifice
[g]
control and
DB289
......
0.882
......
0.612
|
Inbred
|
|
|
liver weight as percent of body weight
[%]
control and
DB289
......
4.26
......
3.88
......
0.911
|
Inbred
|
|
|
|
Inbred
|
|
|
liver weight as a percent of body weight
[%]
high-fat diet
, ethanol
......
6.88
(N=3)
......
7.02
(N=3)
|
Inbred
|
|
|
liver weight
[g]
control and
acetaminophen
......
1.44
(N=4)
24h post-Rx mg/kg:
......
......
......
1.67
|
Inbred
|
| |
|
local experiment parameter
|
|
|
|
Inbred
|
| |
|
reproduction — morphology — male
scales
|
|
|
|
Inbred
|
|
|
|
Inbred
|