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MPD - Phenotype data: orgmetric
organ metrics
Measurements:
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body weight
scales
Harrill2
fold change in body weight over testing period [ratio]
control and
DB289
• control
• DB289
• difference
34
strains
age
6-8wks
Inbred
brain — morphology — size
histopathology
Wahlsten1
corpus callosum
• length at mid-sagittal plane
• cross-sectional area at midplane
• index
21
strains
age
12wks
Inbred
Wahlsten1
hippocampus
• length at mid-sagittal plane
• cross-sectional area at midplane
• index
21
strains
age
12wks
Inbred
Wahlsten1
anterior commissure
• length at mid-sagittal plane
• cross-sectional area at midplane
• index
21
strains
age
12wks
Inbred
brain — morphology — weight
scales
Jaxpheno2
brain weight [g]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
Jaxpheno2
brain weight as percent of body weight [%]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
Wahlsten1
brain weight (after fixation and trimming)
• weight
• as percent of body weight
21
strains
age
12wks
Inbred
cardiovascular — aorta and ventricle dimensions
echocardiography
Jaxpheno8
intra-ventricular septum thickness [mm]
• diastolic
• systolic
• comparison
6
strains
age
12wks
Inbred
Jaxpheno8
left ventricle anterior wall thickness [mm]
• diastolic
• systolic
• comparison
6
strains
age
12wks
Inbred
Jaxpheno8
left ventricle posterior wall thickness [mm]
• diastolic
• systolic
• comparison
6
strains
age
12wks
Inbred
Jaxpheno8
left ventricle internal dimension [mm]
• diastolic
• systolic
• comparison
6
strains
age
12wks
Inbred
Jaxpheno8
left ventricle volume [µL]
• diastolic
• systolic
• comparison
6
strains
age
12wks
Inbred
cardiovascular — heart weight
scales
Deschepper1
ventricle weight [mg]
weight:
• both
• left
• right
normalized:
• both
• left
• right
13
strains
age
10wks
Inbred
Deschepper1
atria weight [mg]
weight:
• both
• left
• right
normalized:
• both
• left
• right
13
strains
age
10wks
Inbred
Eumorphia6
left ventricle weight [mg]
• weight
• normalized
4
strains
age
12wks
Inbred
Jaxpheno2
heart weight [g]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
Jaxpheno2
heart weight as percent of body weight [%]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
Maurer1
heart weight [mg]
control and
atenolol, isoproterenol
2wks
weight:
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
normalized:
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Maurer1
atria weight [mg]
control and
atenolol, isoproterenol
2wks
weight:
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
normalized:
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Maurer1
ventricle (both) weight [mg]
control and
atenolol, isoproterenol
2wks
weight:
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
normalized:
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Maurer1
atria weight to ventricle weight ratio [ratio]
control and
atenolol, isoproterenol
2wks
• control
• atenolol 10mg
• isoprot 1mg
• isoprot 10mg
• comparison
23
strains
age
7-13wks
Inbred
Reed1
heart weight
• weight [g]
• as percent of body weight [%]
28
strains
age
29-67wks
Inbred
endocrine — adrenal — morphology — size
histopathology
DiCurzio1
adrenal width [µm]
• whole gland
• medulla
• comparison
65
strains
age
7-10wks*
BXD
DiCurzio1
adrenal cortex zones [µm]
• zona glomerulosa
• zona intermedia
• zona fasciculata
• zona reticularis
• X-zone
• comparison
65
strains
age
7-10wks*
BXD
endocrine — adrenal — morphology — weight
scales
Deschepper1
adrenal weight [mg]
weight:
• both
• left
• right
normalized:
• both
• left
• right
13
strains
age
10wks
Inbred
DiCurzio1
adrenal weights [mg]
• left
• right
• average
• adjusted to bw
• comparison
66
strains
age
7-10wks*
BXD
eye — morphology
metric
Chang1
eye diameter
[mm]
17
strains
age
>7wks
Inbred
Puk1
axial length [mm]
• left eye
• right eye
• eye comparison
4
strains
age
13wks
Inbred
Puk1
corneal thickness [µm]
• left eye
• right eye
• eye comparison
4
strains
age
13wks
Inbred
Puk1
depth of anterior eye chamber [mm]
• left eye
• right eye
• eye comparison
4
strains
age
13wks
Inbred
Puk1
lens thickness [mm]
• left eye
• right eye
• eye comparison
4
strains
age
13wks
Inbred
immune system — morphology — thymus
scales
Deschepper1
thymus weight [mg]
• weight
• normalized
13
strains
age
10wks
Inbred
kidney — morphology — area
metric
Gupta1
kidney planar surface area [mm
2
]
• left
• right
• comparison
8
strains
age
postnatal d1
Inbred
Gupta1
normalized kidney planar surface area [mm
2
/g]
• left
• right
• comparison
7
strains
age
postnatal d1
Inbred
Gupta2
kidney planar surface area [mm
2
]
• left
• right
• comparison
10
strains
age
postnatal d1
BXH
Gupta2
normalized kidney planar surface area [mm
2
/g]
• left
• right
• comparison
10
strains
age
postnatal d1
BXH
kidney — morphology — weight
scales
Deschepper1
kidney weight [mg]
weight:
• both
• left
• right
normalized:
• both
• left
• right
13
strains
age
10wks
Inbred
Gupta1
kidney weight [g]
• left
• right
• both
• comparison
7
strains
age
postnatal d1
Inbred
Gupta1
percent kidney weight to body weight [%]
• left
• right
• both
• comparison
7
strains
age
postnatal d1
Inbred
Harrill2
kidney (left) weight [g]
control and
DB289
• control
• DB289
• comparison
34
strains
age
6-8wks
Inbred
Harrill2
kidney (right) weight [g]
control and
DB289
• control
• DB289
• comparison
34
strains
age
6-8wks
Inbred
Harrill2
kidney (both) weight [g]
control and
DB289
• control
• DB289
• comparison
34
strains
age
6-8wks
Inbred
Harrill2
total kidney weight as percent of body weight [%]
control and
DB289
• control
• DB289
• difference
34
strains
age
6-8wks
Inbred
Jaxpheno2
kidney (left) weight [g]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
Jaxpheno2
kidney (right) weight [g]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
Jaxpheno2
kidney (left) weight, as percent of body weight [%]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
Jaxpheno2
kidney (right) weight, as percent of body weight [%]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
Reed1
kidney weight
• weight [g]
• as percent of body weight [%]
28
strains
age
29-67wks
Inbred
Gupta2
kidney weight [g]
• left
• right
• both
• comparison
10
strains
age
postnatal d1
BXH
Gupta2
percent kidney weight to body weight [%]
• left
• right
• both
• comparison
10
strains
age
postnatal d1
BXH
liver — weight
scales
Harrill2
liver weight at sacrifice [g]
control and
DB289
• control
• DB289
• comparison
34
strains
age
6-8wks
Inbred
Harrill2
liver weight as percent of body weight [%]
control and
DB289
• control
• DB289
• difference
34
strains
age
6-8wks
Inbred
Jaxpheno2
liver weight [g]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
Jaxpheno2
liver weight as percent of body weight [%]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
Paigen1
liver weight at sacrifice
[g]
high-fat diet
8wks
43
strains
age
15-19wks
Inbred
Rusyn5
liver weight as a percent of body weight [%]
high-fat diet, ethanol
• high-fat only
• high-fat and ethanol
• comparison
14
strains
age
8-14wks
Inbred
Threadgill1
liver weight [g]
control and
acetaminophen
• control
24h post-Rx mg/kg:
• 100
• 200
• 300
• comparison
37
strains
age
8-17wks
Inbred
Cheverud1
liver weight as percent of body weight [%]
control and
high-fat diet
17wks
• control diet
• high-fat diet
• comparison
19
strains
age
20-30wks
LGXSM
Paigen3
liver weight at sacrifice
[g]
high-fat diet
8wks
8
strains
age
15-19wks
obesity mutants
local experiment parameter
Rusyn2
liver weight as percent of body weight, naive
[ratio]
17
strains
age
7wks
Inbred
reproduction — morphology — male
scales
Handel1
seminal vesicle weight (both left and right)
[g]
14
strains
age
8-10wks
Inbred
Handel1
testicular weight (both left and right)
[g]
14
strains
age
8-10wks
Inbred
spleen — weight
scales
Jaxpheno2
spleen weight [g]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
Jaxpheno2
spleen weight, as percent of body weight [%]
• age 8wks
• age 16wks
• age comparison
11
strains
ages shown
Inbred
175 measurements listed.
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