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respiratory
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airway resistance
breathing pattern
immune function
lung compliance
lung volume
mechanics
pulmonary gas exchange
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Phenotype data: respiratory all
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respiratory — airway resistance
ventilator
Berndt1
resistance [cm/mL/s]
• untreated
36
strains
age
9-12wks
Inbred
Berndt1
resistance [cm/mL/s]
baseline and
methacholine
• baseline
MCh challenge (mg/mL):
• 1
• 3
• 10
• 30
• comparison
36
strains
age
9-12wks
Inbred
Berndt1
resistance (percent of baseline) [%]
methacholine
MCh challenge (mg/mL):
• 1
• 3
• 10
• 30
• comparison
36
strains
age
9-12wks
Inbred
Berndt2
airway resistance (H
2
0 pressure) [cm/mL/s]
baseline and
methacholine
• saline
MCh [mg/mL]:
• 1
• 3
• 10
• 30
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
Schulz1
resistance
• system resistance [cm/mL/s]
• system resistance adjusted to lung capacity [cm⋅s]
• comparison
7
strains
age
12-14wks
Inbred
respiratory — breathing pattern — airflow rate
plethysmography
Berndt2
inspiratory flow rate [mL/kg/s]
baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
Berndt2
expiratory flow rate [mL/kg/s]
baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
Berndt2
respiratory flow rate [mL/kg/s]
baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
respiratory — breathing pattern — cycle
plethysmography
Berndt2
inspiratory phase [s]
baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
Berndt2
expiratory phase [s]
baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
Berndt2
respiratory cycle [s]
baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
Berndt2
duty cycle [ratio]
baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
respiratory — breathing pattern — efficiency
plethysmography
Berndt2
minute ventilation [mL/min]
baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
Berndt2
breath frequency [n/min]
baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
respiratory — breathing pattern — enhanced pause
plethysmography
Berndt2
enhanced pause
baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
respiratory — immune function — response to antigen
cytospin centrifuge
Schwartz2
alveolar eosinophils [%]
control and
ovalbumin
i.p.
pre-test:
• control
• OVA-sensitized
• comparison
24h post:
• control
• OVA-sensitized
• comparison
48h post:
• control
• OVA-sensitized
• comparison
72h post:
• control
• OVA-sensitized
• comparison
time curves:
control
OVA-sensitized
8
strains
age
6-8wks
Inbred
Schwartz2
alveolar lymphocytes [%]
control and
ovalbumin
i.p.
pre-test:
• control
• OVA-sensitized
• comparison
24h post:
• control
• OVA-sensitized
• comparison
48h post:
• control
• OVA-sensitized
• comparison
72h post:
• control
• OVA-sensitized
• comparison
time curves:
control
OVA-sensitized
8
strains
age
6-8wks
Inbred
Schwartz2
alveolar neutrophils [%]
control and
ovalbumin
i.p.
pre-test:
• control
• OVA-sensitized
• comparison
24h post:
• control
• OVA-sensitized
• comparison
48h post:
• control
• OVA-sensitized
• comparison
72h post:
• control
• OVA-sensitized
• comparison
time curves:
control
OVA-sensitized
8
strains
age
6-8wks
Inbred
respiratory — lung compliance
ventilator
Berndt2
lung tissue dynamic elastance (H
2
0 pressure) [cm/mL]
baseline and
methacholine
• saline
MCh [mg/mL]:
• 1
• 3
• 10
• 30
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
Schulz1
compliance [µL/cm]
• static (system)
• static (lung)
• dynamic
• comparison
7
strains
age
12-14wks
Inbred
Schulz1
compliance adjusted to lung capacity [1/cm]
• static
• dynamic
• comparison
7
strains
age
12-14wks
Inbred
respiratory — lung volume
plethysmography
Berndt2
tidal volume [mL]
baseline and
methacholine
• saline
MCh [mg/mL]:
• 5
• 10
• 20
• comparison
• MCh response index
29
strains
age
9-12wks
Inbred
respiratory — lung volume
ventilator
Schulz1
volume [µL]
• alveolar
7
strains
age
12-14wks
Inbred
respiratory — mechanics
ventilator
Schulz1
capacity [µL]
• inspiratory
• residual
• total
• vital
• comparison
7
strains
age
12-14wks
Inbred
Schulz1
capacity (adjusted)
• total adjusted to body weight [µL/g]
• vital adjusted to body weight [µL/g]
• residual adjusted to body weight [µL/g]
• residual adjusted to lung capacity [µL/µL]
• comparison
7
strains
age
12-14wks
Inbred
Schulz1
dead space
• Fowler adjusted to lung capacity [µL/µL]
• Fowler adjusted to body weight [µL/g]
• Fowler dead space volume
• comparison
7
strains
age
12-14wks
Inbred
respiratory — pulmonary gas exchange
ventilator
Schulz1
gas mixing and diffusing capacity
• gas mixing [mm/mL]
• diffusing capacity [µmol/min/hPa]
• diffusing capacity adjusted to alveolar volume [µmol/min/hPa/mL]
• comparison
7
strains
age
12-14wks
Inbred
123 measurements listed.
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