Home       About             Help       Phenotype data > C57BL/10J strain > neurosensory Options: nociception sensory gating all Focus: all Measurements: About these C57BL/10J averages (♀ ♂) Exit C57BL/10J mode neurosensory — nociception — chemical         nociception assay   Mogil1 sensitivity to chemical-induced pain [n]         • acetic acid  ......       • magnesium sulfate  ......         • comparison   11 strains   age 6-18wks   Inbred Mogil1 sensitivity to formalin-induced pain [s]         • early phase  ......       • late phase  ......         • time comparison   11 strains   age 6-18wks   Inbred Mogil1 hypersensitivity to chemical-induced pain [s]         • capsaicin  ...... 113         • bee-venom  ...... 193         12 strains   age 6-18wks   Inbred   neurosensory — nociception — mechanical         nociception assay   Mogil1 sensitivity to mechanical-induced pain         • tail clip  ...... 9.70         • von Frey test  ......       12 strains   age 6-18wks   Inbred Mogil1 percent hypersensitivity threshold to mechanical stimulation following dynorphin treatment, von Frey test   [%] ...... -54.4 (N=4) ▼   7 strains   age 6-18wks   Inbred   neurosensory — nociception — neuropathy         nociception assay   Mogil1 effects of peripheral nerve injury (neuropathy)         • autotomy score  ......       • Hargreaves test  ......       • von Frey test  ......       11 strains   age 6-18wks   Inbred   neurosensory — nociception — thermal         nociception assay   Mogil1 latency of nociceptive response, (53°C) hot plate test   [s] ...... 11 strains   age 6-18wks   Inbred Mogil1 Hargreaves test for thermal sensitivity         • baseline  ......       • bee venom (ipsilateral)  ...... 29.7 ▼         • bee venom (contralateral)  ...... 4.80         • carrageenan  ......       11 strains   age 6-18wks   Inbred Mogil1 tail withdrawal following thermally (hot or cold)-induced pain [s]         • 49°C  ......       • –15°C  ...... 8.50           • comparison   11 strains   age 6-18wks   Inbred Mogil1 latency of nociception to heated tail following hindleg acupuncture needles stimulation (analgesia), tail flick test   [s] ...... 4.37   10 strains   age 6-18wks   Inbred Mogil1 tail withdrawal following thermal (47°C) and chemical-induced pain         • baseline thermal sensitivity  ...... 5.60         • thermal hypersensitivity with capsaicin  ...... 8.70         12 strains   age 6-18wks   Inbred   neurosensory — sensory gating         acoustic startle test   Willott1 acoustic startle response (ASR)         sound pressure level:             • 70dB  ...... 99.3   114               • 80dB  ...... 330 ▲   205               • 90dB  ...... 423   276               • 100dB  ...... 483   351                 • comparison   40 strains   age 5-6wks   Inbred Willott1 acoustic startle response (ASR)         • mean latency evoked by 100dB  ...... 24.4   25.8         • habituation ratio  ...... 0.711 ▼   0.706 ▼         40 strains   age 5-6wks   Inbred Willott1 mean prepulse inhibition (PPI), 70dB [ratio]         • 4kHz  ...... 0.581 ▼   0.588 ▼         • 12kHz  ...... 0.328 ▼   0.404         • 20kHz  ...... 0.312 ▼   0.392 ▼         • all tones  ...... 1.22 ▼   1.38 ▼           • comparison   40 strains   age 5-6wks   Inbred

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