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neurosensory
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nociception
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Ontologies
Phenotype data: neurosensory nociception
Measurements:
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neurosensory — nociception — chemical
nociception assay
Mogil1
sensitivity to chemical-induced pain [n]
• acetic acid
• magnesium sulfate
• comparison
11
strains
age
6-18wks
Inbred
Mogil1
sensitivity to formalin-induced pain [s]
• early phase
• late phase
• time comparison
11
strains
age
6-18wks
Inbred
Mogil1
hypersensitivity to chemical-induced pain [s]
• capsaicin
• bee-venom
12
strains
age
6-18wks
Inbred
Koide2
capsaicin solution consumption, percent of baseline [%]
concentration (µM):
• 0.5
• 1
• 4
• 7
• 10
• 15
• comparison
14
strains
age
8-12wks
wild-derived Mishima
neurosensory — nociception — mechanical
nociception assay
Mogil1
sensitivity to mechanical-induced pain
• tail clip
• von Frey test
12
strains
age
6-18wks
Inbred
Mogil1
percent hypersensitivity threshold to mechanical stimulation
following dynorphin treatment, von Frey test
[%]
7
strains
age
6-18wks
Inbred
Chesler1
latency of behavioral response to mechanical pressure [s]
• tail clip test
• Von Frey test
61
strains
age
7-15wks
BXD
Chesler2
latency of nociceptive response to pressure on the tail, 60 s test
[s]
62
strains
age
various
CC diallel
Chesler3
latency of nociceptive response to pressure on the tail, 60 s test
[s]
age
various
CC pre
neurosensory — nociception — neuropathy
nociception assay
Mogil1
effects of peripheral nerve injury (neuropathy)
• autotomy score
• Hargreaves test
• von Frey test
11
strains
age
6-18wks
Inbred
neurosensory — nociception — thermal
nociception assay
Jaxwest1
sensitivity to thermal-induced pain using hotplate
• latency to respond
• hindpaw response
7
strains
age
9-12wks
Inbred
Mogil1
latency of nociceptive response, (53°C) hot plate test
[s]
11
strains
age
6-18wks
Inbred
Mogil1
Hargreaves test for thermal sensitivity
• baseline
• bee venom (ipsilateral)
• bee venom (contralateral)
• carrageenan
11
strains
age
6-18wks
Inbred
Mogil1
tail withdrawal following thermally (hot or cold)-induced pain [s]
• 49°C
• –15°C
• comparison
11
strains
age
6-18wks
Inbred
Mogil1
latency of nociception to heated tail following hindleg
acupuncture needles stimulation (analgesia), tail flick test
[s]
10
strains
age
6-18wks
Inbred
Mogil1
tail withdrawal following thermal (47°C) and chemical-induced pain
• baseline thermal sensitivity
• thermal hypersensitivity with capsaicin
12
strains
age
6-18wks
Inbred
Chesler1
latency of nociception to thermal stimulation [s]
• Hargreaves test
• tail withdrawal
• hot plate
61
strains
age
7-15wks
BXD
Chesler2
latency of nociceptive response to hot plate (54°C), 30 s test
[s]
62
strains
age
various
CC diallel
Chesler3
latency of nociceptive response to hot plate (54°C), 30 s test
[s]
age
various
CC pre
Koide1
sensitivity to thermal-induced pain
• tail flick
• hot plate (lick)
• hot plate (jump)
11
strains
age
8-13wks
wild-derived Mishima
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