Home       About             Help       Phenotype data > PERA/EiJ strain > liver Options: enzyme homeostasis lipid homeostasis pathology protein homeostasis weight all Focus: all Measurements: About these PERA/EiJ averages (♀ ♂) Exit PERA/EiJ mode liver — enzyme homeostasis         ELISA   Threadgill1 cytochrome P450 1A2 isoform [pmol/mg]     control and  acetaminophen 300 mg/kg       • control  ...... 152 (N=3)         • post-Rx 300 mg/kg  ...... 137 (N=2)           • comparison   36 strains   age 8-12wks   Inbred Threadgill1 cytochrome P450 2E1 isoform [pmol/mg]     control and  acetaminophen 300 mg/kg       • control  ...... 120 (N=3)         • post-Rx 300 mg/kg  ...... 53.0 (N=2)           • comparison   36 strains   age 8-12wks   Inbred   liver — enzyme homeostasis         HPLC   Threadgill1 glutathione transferase [µg/mL]     control and  acetaminophen 300 mg/kg       • control  ...... 942 (N=3)         • post-Rx 300 mg/kg  ...... 728 (N=3)         36 strains   age 8-12wks   Inbred   liver — enzyme homeostasis         metabolic panel   Threadgill1 catalase [µg/mL]     control and  acetaminophen 300 mg/kg       • control  ...... 631 (N=3)         • post-Rx 300 mg/kg  ...... 511 (N=3)           • comparison   36 strains   age 8-12wks   Inbred   liver — lipid homeostasis         lipid profile   Paigen1 hepatic cholesterol concentration [mg]   high-fat diet 8wks       • free  ...... 7.90 ▲   6.10 (N=4)         • esterified  ...... 32.8   37.9 (N=4)         • total  ...... 50.7   44.0 (N=4)         • free to esterified ratio  ...... 0.284   0.180 (N=4)         43 strains   age 15-19wks   Inbred   liver — pathology         histopathology   Paigen1 liver pathology (0-4) [score]   high-fat diet 8wks       • images  ......       • microvacuoles  ...... 4.00 (N=3) ▲   3.00 (N=2)         • macrovacuoles  ...... 0 (N=3)   0 (N=2)         • inflammation  ...... 0 (N=3)   0 (N=2)         43 strains   age 15-19wks   Inbred Threadgill1 necrosis [%]     control and  acetaminophen       • control  ...... 0 (N=3)         post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 26.3 (N=3)                 • comparison   37 strains   age 8-17wks   Inbred   liver — protein homeostasis — glutathione         HPLC   Threadgill1 reduced glutathione (GSH) [µmol/g]     control and  acetaminophen       • control  ...... 4.50 (N=2)         • post-Rx 300mg/kg  ...... 4.02 (N=4) ▲           • comparison   35 strains   age 8-17wks   Inbred Threadgill1 oxidized glutathione (GSSG) [µmol/g]     control and  acetaminophen       • control  ...... 0.319 (N=2)         • post-Rx 300mg/kg  ...... 0.294 (N=4) ▲           • comparison   35 strains   age 8-17wks   Inbred Threadgill1 total glutathione (GSH plus GSSG) [µmol/g]     control and  acetaminophen       • control  ...... 5.13 (N=2)         • post-Rx 300 mg/kg  ...... 4.61 (N=4) ▲           • comparison   37 strains   age 8-17wks   Inbred Threadgill1 ratio of reduced (GSH) to oxidized (GSSG) glutathione [ratio]     control and  acetaminophen       • control  ...... 15.6 (N=2)         • post-Rx 300mg/kg  ...... 19.9 (N=4)           • comparison   35 strains   age 8-17wks   Inbred   liver — weight         scales   Paigen1 liver weight at sacrifice   [g] ...... 1.73   1.86 (N=4)     high-fat diet 8wks 43 strains   age 15-19wks   Inbred Threadgill1 liver weight [g]     control and  acetaminophen       • control  ...... 1.04         24h post-Rx mg/kg:             • 100  ......             • 200  ......             • 300  ...... 1.19 (N=3)                 • comparison   37 strains   age 8-17wks   Inbred

Video tutorial session 2 explains the use of this page.

Contact us About MPD Also at JAX

Units Changelog Downloads

Citing Funding Terms of Use