liver — enzyme homeostasis         ELISA   Threadgill1 cytochrome P450 1A2 isoform [pmol/mg]     control and  acetaminophen 300 mg/kg       • control     • post-Rx 300 mg/kg    • comparison   36 strains   age 8-12wks   Inbred Threadgill1 cytochrome P450 2E1 isoform [pmol/mg]     control and  acetaminophen 300 mg/kg       • control     • post-Rx 300 mg/kg    • comparison   36 strains   age 8-12wks   Inbred   liver — enzyme homeostasis         HPLC   Threadgill1 glutathione transferase [µg/mL]     control and  acetaminophen 300 mg/kg       • control     • post-Rx 300 mg/kg  36 strains   age 8-12wks   Inbred   liver — enzyme homeostasis         metabolic panel   Threadgill1 catalase [µg/mL]     control and  acetaminophen 300 mg/kg       • control     • post-Rx 300 mg/kg    • comparison   36 strains   age 8-12wks   Inbred   liver — gene expression         RT-PCR   Rusyn5 Acox1 [%]   high-fat diet , ethanol   gene: Acox1         • high-fat only  • high-fat and ethanol    • comparison   6 strains   age 8-14wks   Inbred Rusyn5 Adipor2 [%]   high-fat diet , ethanol   gene: Adipor2         • high-fat only  • high-fat and ethanol    • comparison   6 strains   age 8-14wks   Inbred Rusyn5 Ahcy [%]   high-fat diet , ethanol   gene: Ahcy         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Cbs [%]   high-fat diet , ethanol   gene: Cbs         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Cebpa [%]   high-fat diet , ethanol   gene: Cebpa         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Cth [%]   high-fat diet , ethanol   gene: Cth         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Ddit3 (Chop) [%]   high-fat diet , ethanol   gene: Ddit3         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Gnmt [%]   high-fat diet , ethanol   gene: Gnmt         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Mat1a [%]   high-fat diet , ethanol   gene: Mat1a         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Mthfr [%]   high-fat diet , ethanol   gene: Mthfr         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Mtr [%]   high-fat diet , ethanol   gene: Mtr         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 Mttp [%]   high-fat diet , ethanol   gene: Mttp         • high-fat only  • high-fat and ethanol    • comparison   6 strains   age 8-14wks   Inbred Rusyn5 Srebf1 [%]   high-fat diet , ethanol   gene: Srebf1         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred   liver — lipid homeostasis         lipid profile   Paigen1 hepatic cholesterol concentration [mg]   high-fat diet 8wks       • free  • esterified  • total   • free to esterified ratio  43 strains   age 15-19wks   Inbred Rusyn5 hepatic triglycerides (TG) [mg/g]   high-fat diet , ethanol       • high-fat only  • high-fat and ethanol    • comparison   6 strains   age 8-14wks   Inbred Schonfeld1 hepatic triglycerides (5h fast)   [mg/g] 10 strains   age 9-13wks   Inbred Paigen3 hepatic cholesterol concentration [mg]   high-fat diet 8wks       • free  • esterified  • total   • free to esterified ratio  8 strains   age 15-19wks   obesity mutants   liver — mineral homeostasis         mass spectrometry   Vulpe1 liver mineral [µg/g]         • copper  • iron  • zinc    • comparison   18 strains   age 8wks   Inbred   liver — pathology         histopathology   Paigen1 liver pathology (0-4) [score]   high-fat diet 8wks       • images  • microvacuoles  • macrovacuoles  • inflammation  43 strains   age 15-19wks   Inbred Rusyn5 liver steatosis (0-4) [score]   high-fat diet , ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver inflammation (0-2) [score]   high-fat diet , ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver necrosis (0-2) [score]   high-fat diet , ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 total liver histopathology (0-8) [score]   high-fat diet , ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Threadgill1 necrosis [%]     control and  acetaminophen       • control     post-Rx mg/kg: • 100  • 200  • 300    • comparison   37 strains   age 8-17wks   Inbred Threadgill2 liver necrosis score   [%]   acetaminophen 300mg/kg 5 strains   age 6-8wks   Inbred Threadgill2 percent nitrotyrosine staining (marker of hepatocyte injury)   [%]   acetaminophen 300mg/kg 5 strains   age 6-8wks   Inbred Paigen3 liver pathology (0-4) [score]   high-fat diet 8wks       • images  • microvacuoles  • macrovacuoles  • inflammation  8 strains   age 15-19wks   obesity mutants   liver — pathology — hepatotoxicity         histopathology   Klaassen1 Cd-induced toxicity to liver   [designation]   cadmium 9 strains   age 8wks   Inbred   liver — protein homeostasis         HPLC   Rusyn5 liver homocysteine [nmol/mg]   high-fat diet , ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver S-adenosylhomocysteine (SAH) [nmol/mg]   high-fat diet , ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver methionine [nmol/mg]   high-fat diet , ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 liver S-adenosylmethionine (SAM) [nmol/mg]   high-fat diet , ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 ratio of liver SAM to SAH (SAM/SAH) [ratio]   high-fat diet , ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred   liver — protein homeostasis         Western blot   Rusyn5 BHMT [%]   high-fat diet , ethanol   gene: Bhmt         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 DDIT3 (CHOP) [%]   high-fat diet , ethanol   gene: Ddit3         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 HSPA5 (GRP78) [%]   high-fat diet , ethanol   gene: Hspa5         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 SREBF1 (NSREBP1) [%]   high-fat diet , ethanol   gene: Srebf1         • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred   liver — protein homeostasis — glutathione         HPLC   Rusyn5 reduced liver glutathione (GSH) [nmol/mg]   high-fat diet , ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 oxidized liver glutathione (GSSG) [nmol/mg]   high-fat diet , ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Rusyn5 ratio of reduced to oxidized liver glutathione [ratio]   high-fat diet , ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Threadgill1 reduced glutathione (GSH) [µmol/g]     control and  acetaminophen       • control     • post-Rx 300mg/kg    • comparison   35 strains   age 8-17wks   Inbred Threadgill1 oxidized glutathione (GSSG) [µmol/g]     control and  acetaminophen       • control     • post-Rx 300mg/kg    • comparison   35 strains   age 8-17wks   Inbred Threadgill1 total glutathione (GSH plus GSSG) [µmol/g]     control and  acetaminophen       • control     • post-Rx 300 mg/kg    • comparison   37 strains   age 8-17wks   Inbred Threadgill1 ratio of reduced (GSH) to oxidized (GSSG) glutathione [ratio]     control and  acetaminophen       • control     • post-Rx 300mg/kg    • comparison   35 strains   age 8-17wks   Inbred Threadgill2 reduced glutathione (GSH) [µmol/mg]     control and  acetaminophen 300mg/kg       • control  • post-Rx 300 mg/kg    • comparison   5 strains   age 6-8wks   Inbred Threadgill2 percent reduced glutathione [%]     control and  acetaminophen 300mg/kg       • control  • post-Rx 300 mg/kg    • comparison   5 strains   age 6-8wks   Inbred Threadgill2 total glutathione [µmol/mg]     control and  acetaminophen 300mg/kg       • control  • post-Rx 300 mg/kg    • comparison   5 strains   age 6-8wks   Inbred   liver — weight         scales   Harrill2 liver weight at sacrifice [g]     control and  DB289       • control  • DB289    • comparison   34 strains   age 6-8wks   Inbred Harrill2 liver weight as percent of body weight [%]     control and  DB289       • control  • DB289  • difference  34 strains   age 6-8wks   Inbred Jaxpheno2 liver weight [g]         • age 8wks  • age 16wks    • age comparison   11 strains   ages shown   Inbred Jaxpheno2 liver weight as percent of body weight [%]         • age 8wks  • age 16wks    • age comparison   11 strains   ages shown   Inbred Paigen1 liver weight at sacrifice   [g]   high-fat diet 8wks 43 strains   age 15-19wks   Inbred Rusyn5 liver weight as a percent of body weight [%]   high-fat diet , ethanol       • high-fat only  • high-fat and ethanol    • comparison   14 strains   age 8-14wks   Inbred Schonfeld1 liver weight   [g] 10 strains   age 9-13wks   Inbred Schonfeld1 liver weight as a percent of body weight   [%] 10 strains   age 9-13wks   Inbred Threadgill1 liver weight [g]     control and  acetaminophen       • control     24h post-Rx mg/kg: • 100  • 200  • 300    • comparison   37 strains   age 8-17wks   Inbred Cheverud1 liver weight as percent of body weight [%]     control and  high-fat diet 17wks       • control diet  • high-fat diet    • comparison   19 strains   age 20-30wks   LGXSM Paigen3 liver weight at sacrifice   [g]   high-fat diet 8wks 8 strains   age 15-19wks   obesity mutants

130 measurements listed.